Biomedical subjects

Pisake Lumbiganon

Publications and source records attributed to Pisake Lumbiganon.

22 records · Page 2Linked to original sources

PubMed2002

Side effects of oral misoprostol during the first 24 hours after administration in the third stage of labour.

OBJECTIVE: To evaluate the side effects of 600 microg misoprostol orally during the first 24 hours after administration in the third stage of labour. DESIGN: Double blind randomised controlled trial. SETTING: Tertiary care hospitals in Nigeria and Thailand. SAMPLE: All women participating in the WHO Misoprostol trial in these two hospitals between January 1, 1999 and June 17, 1999. METHODS: All women were followed up during the first 24 hours postpartum to evaluate the occurrence of shivering, nausea, vomiting, diarrhoea and other misoprostol-related side effects. MAIN OUTCOME MEASURES: Rates of shivering, nausea, vomiting, diarrhoea and pyrexia within 1 hour and in the intervals 2-6, 7-12, 13-18 and 19-24 hours after delivery. RESULTS: A total of 1686 women were enrolled. Women who received misoprostol had higher incidence than the oxytocin group of 'any' shivering in the first hour (RR 6.4, 95% CI 3.9 to 10.4) and the period covering 2-6 hours following delivery (RR 4.7, 95% CI 1.9 to 11.2). Pyrexia was also more common in the misoprostol group in both the same time intervals (RR 2.8, 95% CI 1.4 to 5.3 and RR 6.3, 95% CI 3.7 to 10.8, respectively). Diarrhoea was not present in the first hour in either group but appeared in the second time period (2-6 hours) and third time period (7-12 hours) more frequently in the misoprostol group than with oxytocin. CONCLUSION: The increased incidence of shivering and pyrexia that occurs with postpartum use of misoprostol persists up to 6 hours following delivery. Approximately 5% of women experience diarrhoea that starts after 1 hour and subsides within 12 hours.

Administration, Oral↗

PubMed2002

Prophylactic antibiotic prescription for cesarean section.

OBJECTIVES: To assess the use of prophylactic antibiotics for cesarean section, and to identify factors associated with a doctor's intraoperative prescription. DESIGN: A hospital-based, cross-sectional study. STUDY PARTICIPANTS: All 967 medical records of women undergoing cesarean section from January 1998 to February 1999 in a university hospital, Southern Thailand. MAIN MEASURES: Independent variables consisted of patient and doctor factors. The outcome variable was whether any antibiotics were given intraoperatively. Multivariate logistic regression with random effects was used to identify factors associated with the doctor's prescription. RESULTS: Prophylactic antibiotics were prescribed in 82% of all patients. One hundred and eighty-eight patients (21%) received antibiotics postoperatively. Of the patients receiving intraoperative antibiotics after cord clamping, 8% received only a single dose and 53% received an additional postoperative prescription. The most commonly used antibiotic was ampicillin. Intraoperative prescription was significantly associated with longer duration of ruptured membranes, higher number of vaginal examinations and doctors' age. Doctors aged 30-39 years had three and seven times the likelihood of prescribing intraoperative antibiotics compared with their younger and older colleagues, respectively. CONCLUSIONS: Administration of single-dose prescriptions was still an uncommon practice. Prophylaxis was given more commonly to patients with well known risks for infection, and was given by doctors aged 30-39 years.

Adult↗

PubMed2002

Reagent strip testing is not sensitive for the screening of asymptomatic bacteriuria in pregnant women.

The objective of the study was to assess the diagnostic performance of the reagent strip in screening for asymptomatic bacteriuria in pregnant women using urine culture as a gold standard. This study comprised 204 asymptomatic pregnant women who attended their first antenatal care at Srinagarind Hospital, Khon Kaen University from April 1, 1999 to June 30, 1999. Women with symptoms of urinary tract infection, antibiotic treatment within the previous 7 days, pregnancy-induced hypertension, bleeding per vagina and history of urinary tract diseases were excluded. Urine specimens were collected by clean catched midstream urine technique for urinalysis, reagent strip test and urine culture. Diagnostic performance of reagent strip in terms of sensitivity, specificity, positive and negative predictive value was analyzed. Urine reagent strip test had a sensitivity of 13.9 per cent, a specificity of 95.6 per cent, a positive predictive value of 46.1 per cent, a negative predictive value of 80.6 per cent in detecting asymptomatic bacteriuria in pregnant women.

Adult↗

PubMedDate not supplied

Panel 2.1: assessing impact and needs.

This is a summary of the presentations and discussion of Panel 2.1 of the Conference, Health Aspects of the Tsunami Disaster in Asia, convened by the World Health Organization (WHO) in Phuket, Thailand, 04-06 May 2005. The topics discussed included issues related to assessing needs and measuring impact as pertaining to the responses to the damage created by the Tsunami. It is presented in the following major sections: (1) key questions; (2) assessing needs; (3) measuring impact; and (4) lessons learned and recommendations.

Disasters↗