Plamen M Kossev | PubMed Health

PubMed2003

Hypereosinophilia associated with cardiac rhabdomyosarcoma.

Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm(3), is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms.

Adult↗

PubMed2002

Frozen sections in hematopathology.

The diagnostic complexity of lymphoproliferative disorders has increased tremendously within the last decade as evidenced by the recently published World Health Organization (WHO) classification of hematological malignancies. Diagnosis of these malignancies now often requires confirmation by ancillary studies, such as immunohistochemistry, flow cytometry, cytogenetics, and/or molecular studies. In fact, in some cases, these ancillary studies are diagnostic rather than simply confirmatory; furthermore, results from these studies may play a direct role in selecting patient therapy. Importantly, this comprehensive approach to the diagnosis of hematological disorders starts at the time of receipt of fresh tissue in the anatomic pathology laboratory. Appropriate handling and triaging of this fresh tissue, which includes recognizing grossly abnormal areas, interpreting the frozen section, and deciding to send portions of the specimen to ancillary laboratories, is pivotal to the optimal diagnosis, prognostication, and ultimate management of the patient.

Frozen Sections↗