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Biomedical subjects

Poo-Sing Wong

Publications and source records attributed to Poo-Sing Wong.

8 recordsLinked to original sources
PubMed2004

Combined blunt aortic and bronchial injury.

We report the case of a 29-year-old man with left blunt chest trauma resulting in an intimal tear of the proximal descending aorta, for which he underwent successful thoracic endovascular graft stenting. He subsequently developed progressive left lung collapse, and bronchoscopy revealed left bronchial disruption. A left thoracotomy with end-to-end anastomosis of the left bronchus was performed successfully. The literature from 6 other similar cases of concomitant aortic and bronchial injuries was reviewed.

Accidents, Traffic↗
PubMed2004

Posterior mediastinal goiter.

Most mediastinal goiters are retrosternally situated in the anterior mediastinal compartment. Posterior mediastinal goiters, either retrotracheal or retroesophageal, are rare. We herein describe a case involving a retrotracheal goiter in the right posterior mediastinum, which was excised using a combined cervico-partial sternotomy and right thoracotomy approach.

Cough↗
PubMed2003

Feasibility of using low-volume tissue samples for gene expression profiling of advanced non-small cell lung cancers.

PURPOSE: The majority of patients with non-small cell lung cancer (NSCLC) present at an advanced clinical stage, when surgery is not a recommended therapeutic option. In such cases, tissues for molecular research are usually limited to the low-volume samples obtained at the time of diagnosis, usually via fine-needle aspiration (FNA). We tested the feasibility of performing gene expression profiling of advanced NSCLCs using amplified RNA from lung FNAs. EXPERIMENTAL DESIGN AND RESULTS: A total of 46 FNAs was tested, of which 18 yielded RNA of sufficient quality for microarray analysis. Expression profiles of these 18 samples were compared with profiles of 17 pairs of tumor and normal lung tissues that had been surgically obtained. Using a variety of unsupervised and supervised analytical approaches, we found that the FNA profiles were highly distinct from the normal samples and similar to the tumor profiles. CONCLUSIONS: We conclude that when RNA amplification is successful, gene expression profiles from NSCLC FNAs can determine malignancy and suggest that with additional refinement and standardization of sample collection and RNA amplification protocols, it will be possible to conduct additional and more detailed molecular analysis of advanced NSCLC using lung FNAs.

Biopsy, Needle↗