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Biomedical subjects

Q Debray

Publications and source records attributed to Q Debray.

At least 19 recordsLinked to original sources
PubMed1985

[Haloperidol. Plasma monitoring and hormonal effects of treatment].

Therapeutic plasma monitoring of haloperidol, a major neuroleptic, measured by radioimmunoassay, has shown a rather good correlation between plasma level and dosage but with large interindividual variation in children as in adults; age seems not to have any effect on haloperidol metabolism. 80% of subjects present a concomitant prolactin levels variation, whereas in 20% no prolactin response is found. During acute kinetics of either a 10 mg oral haloperidol administration or a 250 mg intramuscular haloperidol decanoate injection, a parallel elevation of prolactin, cortisol, immunoreactive bêta-endorphin and bêta-lipotropin plasma levels occur, at the same time as haloperidol plasma levels. Those rise with a good equivalence between the two doses of the two forms.

Administration, Oral↗
PubMed1985

[The insomnias].

Explore the source record for details and available documents.

Depression↗
PubMed1979

Schizophrenia: a study of genetic models.

The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control 'sporadic' model. The control model gave a log10 likelihood (L), of -240.92. Five of the genetic models were definitely excluded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: -220.05); two interacting loci (L:-219.46); and four polygenes (L:-216.87).

Alleles↗
PubMed1978

Schizophrenia: a study of genetic models and some of their implications.

The likelihoods of observing 25 four-generational families of schizophrenics comprising 1,333 individuals have been calculated on the basis of 12 different genetic models and one control 'sporadic' model. The control model gave a log10 likelihood, L, of -240.92. Five of the genetic models were definitely exlcuded as incompatible with certain pedigrees. The three models with the highest likelihoods were: one locus, the heterozygote having a 10% probability of being classified schizophrenic (L: - 220.05); two interacting loci (L: -219.46), and four polygenes (L: -216.87).

Alleles↗
PubMed1978

[Nondiscal sciatica without organic lesion].

Among 1 800 patients operated on for hernia of the disc, 2% were completely negative on surgical exploration. Since a psychiatric aetiology might be involved, these patients were again given physical examination, clinical psychiatric examination and a personality test (minimult). This psychometric examination yelded pathological results in 68% of these patients. A comparison with two control groups operated on for hernia of the disc permitted a distinction of statistically significant differences. The results are compared with similar studies by other authors on patients with lumbalgia and dorsalgia. A practical approach is defined.

Adult↗