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Q Milner

Publications and source records attributed to Q Milner.

4 recordsLinked to original sources
PubMed2000

Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass.

Clevidipine is a new vascular-selective, calcium channel antagonist of the dihydropyridine type with an ester side chain susceptible to esterase metabolism. In healthy volunteers, it has high clearance (0.069 litres min-1 kg-1) with a small volume of distribution at steady state (0.19 litres kg-1). The half-lives of the two initial rapid phases, accounting for approximately 95% of the area under the curve after an i.v. bolus, are 0.7 and 2.3 min, respectively. The aims of this study were to determine the pharmacokinetics and the pulmonary extraction ratio of clevidipine in patients undergoing cardiac surgery. Seventeen patients received clevidipine as an i.v. infusion before cardiopulmonary bypass (CPB), and eight of these patients were also given clevidipine during hypothermic CPB. Mixed venous and arterial blood samples were taken for pharmacokinetic analysis and calculation of pulmonary extraction ratio. A two-compartment pharmacokinetic model with zero-order input was used to describe the pharmacokinetics of clevidipine before and during CPB. Virtually identical concentrations in mixed venous and arterial blood suggest negligible pulmonary metabolism of clevidipine. The total blood clearance of clevidipine is extremely high (0.055 litres min-1 kg-1). During CPB, clearance of clevidipine was significantly reduced, to 0.03 litres min-1 kg-1 (P < 0.005), probably as a consequence of reduced body temperature.

Adult↗
PubMed1999

Haemodynamic changes after tracheal intubation in cigarette smokers compared with non-smokers.

We have studied the haemodynamic changes in response to tracheal intubation in 60 ASA I women undergoing elective gynaecological surgery; 30 women smoked more than 10 cigarettes a day, while the other 30 were non-smokers. Immediately after intubation, heart rate of smokers (mean 102.0 (SD 17) beat min-1) was significantly greater (P < 0.01) than that of non-smokers (mean 91.0 (12.3) beat min-1). This may be clinically important in smokers who are at risk of ischaemic heart disease and also relevant for future studies investigating haemodynamic responses to intubation.

Adult↗