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Biomedical subjects

Q X Gao

Publications and source records attributed to Q X Gao.

9 recordsLinked to original sources
PubMed2000

[Influence of smoking on nasal airway resistance].

OBJECTIVE: To discuss the influence of smoking on nasal airway resistance (NAR). METHOD: The unilateral and total NAR of 40 normal controls, 41 slight smokers and 42 heavy smokers were evaluated by anterior rhinomanometry before and after nasal decongestion. RESULT: Before nasal decongestion, the unilateral and total NAR of heavy smokers increased significantly (P < 0.05) compared with that of normal controls. After decongestion, there was no significant difference (P > 0.05). Whenever before or after decongestion, there was no significant difference between slight smokers and normal controls (P > 0.1). CONCLUSION: Long-time and heavy smoking can enhance the NAR, which may be due to the chang of blood vessels in nasal mucosa.

Adolescent↗
PubMed2000

[A new method to evaluate the eustachian tube function].

OBJECTIVE: To study the practicality of a new method to evaluate eustachian tube function. METHOD: We acquired the tympanogram of 30 normal persons (60 cases) by means of classical tympanometry, Toynbee test and valsalva maneuvre respectively, the peak point of each tympanogram was P1, P2 and P3 corresponding P1 -P2 > 10 daPa or Pmax-Pmin > 15 daPa was accepted as normal. RESULT: 70% cases were accepted normal, whose peak point shifted obviously. CONCLUSION: The method is a simple, objective and practical one; If the peak point shifts obviously, the function of ET is normal; On the contrary, if the function of ET may be abnormal, other tests should be performed.

Acoustic Impedance Tests↗
PubMed2000

[The evaluation of eustachian tube function in patients suffered from SOM with C type curve].

OBJECTIVE: To explore eustachian tube (ET) function in patients suffered from SOM with C type curve. METHOD: To test the tympanogram following toynbee test and valsalva manoeuvre respectively. The shift of peak point was quantified and the results were compared with normal subjects. RESULT: ET dysfunction was found in 52.38% of the patients, it was observed in 30% of the normal subjects (P < 0.05). CONCLUSION: ET dysfunction is one of the causes of SOM with C type curve, but not the only cause.

Acoustic Impedance Tests↗
PubMed2000

Alleviation of pre-exposure to low-dose 16O8+ ion on mouse testicular histological damage induced by subsequent high-dose irradiation.

The testes of the B6C3F1 hybrid strain mice were irradiated with 0.05 Gy of 16O8+ ion as the pre-exposure dose (D1), and were then irradiated with 2 Gy of 16O8+ ion as challenging radiation dose (D2) at 4 h after per-exposure. Testicular morphology was observed by light microscope at 35th day after radiation. The results showed that irradiation of mouse testes with 2 Gy of 16O8+ ion significantly impaired, mainly reduction of tubule diameter and decrease or loss of germ cells in various developing stages, especially spermatogenic elements. Pre-exposure to a low-dose (0.05 Gy) of 16O8+ ion significantly alleviated above mentioned damage on testicular morphology induced by subsequent a high-dose (2 Gy) radiation.

Animals↗
PubMed2000

[The study of the distortion product emission in the people with hypertriglyceride].

OBJECTIVE: To study the change of the amplitude and latency of the distortion product emission (DPOAE) in the people with hypertriglyceride. METHOD: The DPOAE amplitude and latency of 30 people with hypertriglyceride and 18 normal was acquired with ILO-V5. RESULT: Although the hearing threshold of pure tone was not affected, but DPOAE amplitude of the people with hypertriglyceride was significantly decreased with the normal people, the changes of latency was not significantly affected. CONCLUSION: The cochlea of patient with hyperlipidemia may be damage in its early-stage. The generating mechanism of DPOAE latency and amplitude may be different.

Adult↗
PubMed2000

[The role of tracheotomy in saving the patients suffered from lung blast injury].

OBJECTIVE: To explore the role of tracheotomy in saving the patients suffered from lung blast injury. METHOD: To analyse the pathological change of lung blast injury and to make a retrospective analysis for clinical data of 8 cases. RESULT: Three severe injuries accompanying asphyxia, SaO2 < 75%, were tracheotomized and sucked hemorrhagic frothy sputum in trachea at once, and they were saved successfully. The other 5 cases, SaO2 > or = 90%, were not tracheotomized. CONCLUSION: During saving the lung blast injury, tracheotomy has an important role in sucking hemorrhagic frothy sputum in trachea and keeping the respiratory tract unobstructed.

Adolescent↗
PubMed1998

Chromosomal aberrations induced by 12C6+ heavy ion irradiation in spermatogonia and spermatocytes of mice.

The testes of Kun-Ming strain mice were radiated with different doses of 12C6+ ion or 60Co gamma-ray. Chromosomal aberrations induced in spermatogonia and spermatocytes were analyzed by the air-drying method. The relative biological effectiveness (RBE) of 12C6+ ion was calculated with respect to 60Co gamma-ray for the induction of chromosomal aberrations. The 12C6+ ion and 60Co gamma-ray dose-response relationships for chromosomal aberrations were plotted by linear quadratic models. The results showed that there was an increase in frequency of chromosomal aberrations in all the treated groups compared to controls. The RBE values were 1.67 for aberrations of spermatogonia and 1.66 for aberrations of spermatocytes for a dose of 2.0 Gy. Moreover, a different distribution of the various types of aberrations has been found for 12C6+ ion and 60Co gamma-ray irradiations. The dose-response relationships for 12C6+ ion and 60Co gamma-ray exhibited negative curvature in both spermatogonia and spermatocytes groups: the frequencies of aberrations increased sharply at low doses and exhibited less sharp increases for higher doses, which may be related to an interaction between the chromosomal damage and a block in cell cycle. Our results may provide useful information for the assessment of genetic risks of humans exposed to heavy ions.

Animals↗
PubMed1998

Effects of pre-exposure of mouse testis with low-dose (16)O8+ ions or 60Co gamma-rays on sperm shape abnormalities, lipid peroxidation and superoxide dismutase (SOD) activity induced by subsequent high-dose irradiation.

PURPOSE: To investigate the effects of pre-exposure of mouse testis with low-doses of (16)O8+ ions or 60Co gamma-rays on sperm shape abnormalities, lipid peroxidation and superoxide dismutase (SOD) activity induced by subsequent high-dose irradiation. MATERIALS AND METHODS: Testes of the B6C3F1 hybrid strain mice were pre-irradiated with 0.05 Gy of (16)O8+ ions or 60Co gamma-rays and then after 4 h given a test irradiation with 2 Gy of the same radiation type. SOD activity and thiobarbituric acid reactive substances (TBARS) in the testes were determined by spectrophotometric and TBA methods respectively at 4 h after irradiation. Testis weight, sperm count and sperm morphology were analysed at day 35 after irradiation. RESULTS: Compared with controls, there was a significant increase in SOD activity and a significant decrease in TBARS level of pretreated testes. Testis weight loss, sperm count reduction and sperm abnormalities were significantly lower in the pretreated testes. The bioeffects of a 2 Gy dose of (16)O8+ ions relative to 60Co gamma-rays were 1.84 +/- 0.28 for testis weight, 1.22 +/- 0.25 for sperm count and 1.29 +/- 0.10 for sperm abnormalities. CONCLUSIONS: These data suggest that pre-exposure of testes with a low dose of heavy ions or gamma-rays renders the organ more resistant to subsequent high-dose irradiation. The increase of SOD activity and the decrease of lipid peroxidation levels induced by low-dose ionizing irradiation may be involved in this resistance. The effects with heavy ion irradiation were greater than with gamma-rays.

Animals↗