PubMed2006
OBJECTIVE: To investigate the correlation between glucose metabolism status and coronary artery lesion in the patients undergoing their first coronary angiography (CAG). METHODS: Oral glucose tolerance test (OGTT) and CAG were performed in 553 patients with suspected or confirmed coronary artery disease (CAD), aged 60.1 +/- 9.7. The anthroposomatologic parameters, blood pressure, HbA1c, and lipid profile of these patients were collected. Their glucose metabolism status was assessed based on the WHO diagnostic criteria of diabetes mellitus 1999 and American Heart Association's grading standards for evaluating coronary artery stenosis and Gensini score were applied to analyze the coronary artery lesion. According to the CAG results the patients were divided into CAD group and non-CAD group and then the glucose metabolic characteristics in both groups were analyzed by comparison based on the glycometabolic status. The patients were also grouped into diabetic and non-diabetic groups and the coronary artery angiographic features in both groups were compared. RESULTS: Among the 533 patients 277 (50.1%) had normal OGTT, 127 (23.0%) were diagnosed as with impaired glucose regulation, 61 (11%) were newly diagnosed as with type 2 diabetes mellitus, and the other 88 patients (15.9%) were already known diabetics. The prevalence of abnormal glycometabolism in the CAD group was 56.4%, significantly higher than that in the non-CAD group (34.5%, P < 0.05). The prevalence of multiple branches involvement in the diabetic group was 63.8%, significantly higher than that of the non-diabetic group (44.1%, P < 0.05), and the Gensini score in the diabetic group was 15 (30.5), significantly higher than that of the [20 (27), P < 0.05]. CONCLUSION: Abnormal glycometabolism is common in the population undergoing coronary angiography. Both the prevalence of multiple branches involvement and the degree of stenosis of coronary in the diabetics are higher than that in those without diabetes.