Biomedical subjects

Qian Liu

Publications and source records attributed to Qian Liu.

75 records · Page 5Linked to original sources

PubMed2002

[Hand-assisted laparoscopic surgery in colorectal carcinoma resection: a report of 14 cases].

OBJECTIVE: To study the application of hand-assisted laparoscopic surgery (HALS) in colorectal carcinoma resection. METHODS: Fourteen patients with colorectal carcinoma underwent resection by HALS. RESULTS: Hand-assisted laparoscopic right hemicolectomy was performed in 6 of 8 ascending colon cancer patients, spending an average of 160 minutes (110 to 220 minutes) for the procedure. The amount of bleeding was 40 approximately 100 ml. Bowel sounds resumed in 36 approximately 72 hours after the operation. The average interval between the operation and patients' discharge was 8 days (7 to 12 days). For 2 patients the surgeons had to resort to laparotomy. All patients received postoperative chemotherapy. Hand-assisted laparoscopic abdominoperineal resection was performed in 5 of 6 patients with lower rectal cancer, with the average duration of 180 minutes (120 to 270 minutes), with bleeding of 40 to 80 ml. Bowel sounds resumed within 24 to 72 hours and the average discharge interval was 14 days (12 to 18 days). The urinary catheter in 6 patients was removed in 7 to 8 days after the operation. All patients with rectal carcinoma received postoperative chemotherapy and radiotherapy. One patient was shifted to laparotomy because of extensive adhesion in the pelvic cavity. Four of 11 patients treated by HALS experienced slight pain in the incision. No other complications were observed in any of the patients. Remote results await further follow-up. CONCLUSION: Hand-assisted laparoscopic surgery in the treatment of colorectal carcinoma, a safe and simple procedure, not only ensures the clearance of tumor, but also reduces operative trauma and hastens recovery.

Adult↗

PubMed2001

CB2 cannabinoid receptor-mediated peripheral antinociception.

Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB(1) receptor in the production of antinociception. However, the capacity of CB(2) receptors, which are located outside the central nervous system (CNS), to produce antinociception is not known. Using AM1241, a CB(2) receptor-selective agonist, we demonstrate that CB(2) receptors produce antinociception to thermal stimuli. Injection of AM1241 in the hindpaw produced antinociception to a stimulus applied to the same paw. Injection of an equivalent dose of AM1241 into the paw contralateral to the side of testing did not. The antinociceptive actions of AM1241 were blocked by the CB(2) receptor-selective antagonist AM630, but not by the CB(1) receptor-selective antagonist AM251. AM1241 also produced antinociception when injected systemically (intraperitoneally). The antinociceptive actions of systemic AM1241 were blocked by injection of AM630 into the paw where the thermal stimulus was applied, but not the contralateral paw. These findings demonstrate the local, peripheral nature of CB(2) cannabinoid antinociception. AM1241 did not produce the CNS cannabinoid effects of hypothermia, catalepsy, inhibition of activity or impaired ambulation, while this tetrad of effects was produced by the mixed CB(1)/CB(2) receptor agonist WIN55,212-2. Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects.

Analgesics↗

PubMedDate not supplied

Temporal clustering analysis of cerebral blood flow activation maps measured by laser speckle contrast imaging.

Temporal and spatial orchestration of neurovascular coupling in brain neuronal activity is crucial for comprehending the mechanism of functional cerebral metabolism and pathophysiology. Laser speckle contrast imaging (LSCI) through a thinned skull over the somatosensory cortex is utilized to map the spatiotemporal characteristics of local cerebral blood flow (CBF) in anesthetized rats during sciatic nerve stimulation. The time course of signals from all spatial loci among the massive dataset is hard to analyze, especially for the thousands of images, each of which composes millions of pixels. We introduce a temporal clustering analysis (TCA) method, which is proven as an efficient method to analyze functional magnetic resonance imaging (fMRI) data in the temporal domain. The timing and location of CBF activation shows that contralateral hindlimb sensory cortical microflow is activated to increase promptly in less than 1 s after the onset of 2-s electrical stimulation and is evolved in different discrete regions. This pattern is similar but slightly elaborated from the results obtained from laser Doppler flowmetry (LDF) and fMRI. We present this combination to investigate interacting brain regions, which might lead to a better understanding of the nature of brain parcellation and effective connectivity.

Animals↗