Biomedical subjects

Qing Ye

Publications and source records attributed to Qing Ye.

At least 19 recordsLinked to original sources

PubMed2026

From decline to resurgence: current perspectives on Mycoplasma pneumoniae.

SUMMARYMycoplasma pneumoniae pneumonia (MPP) is an acute respiratory infection caused by Mycoplasma pneumoniae (MP) and constitutes the primary cause of community-acquired pneumonia (CAP) among children aged 5 years and older in China. The clinical manifestations of MP-associated respiratory disease in children are diverse, ranging from mild upper respiratory symptoms to life-threatening pneumonia. Notably, during the implementation of nonpharmaceutical interventions (NPIs) aimed at curbing SARS-CoV-2 transmission, there was a significant decline in MP infection rates. However, a pronounced global resurgence of MP infections was documented in 2023-2024. The increasing global prevalence of macrolide resistance, particularly in China, coupled with limited alternative antibiotic options for children, increasing rates of coinfections, and the absence of a preventive vaccine, collectively exacerbate treatment challenges and increase the disease burden. Furthermore, the insufficient availability of MP nucleic acid testing and antimicrobial resistance surveillance in primary healthcare settings, coupled with the absence of a comprehensive epidemiological monitoring network, results in a vicious public health cycle. Recent advances and emerging genomic data have provided new insights into its pathogenesis and clinical management. Therefore, in this narrative review, we aim to (i) synthesize the current understanding of the etiological characteristics of MP and the present status of MPP diagnosis and treatment; (ii) analyze recent advances and drivers behind the global resurgence of MP infections; and (iii) propose integrated prevention and control strategies to increase the recognition of MPP and prevent unanticipated outbreaks.

Humans↗

PubMed2007

Selection and characterization of an internalizing epidermal-growth-factor-receptor antibody.

Antibody-therapeutic agent conjugates to be delivered directly into the cytosol of tumour cells is required for many target-based therapeutic strategies. For this work, a large non-immune phage-display library was used to select internalizing scFv (single chain variable fragment) directed against EGFR (epidermal growth factor receptor), a tyrosine kinase receptor that is overexpressed in a wide range of tumour cells. The CHO-EGFR-GFP1 (where CHO is Chinese-hamster ovary) cell line, a transfected cell line expressing EGFR-GFP (green fluorescent protein) fusion protein on membranes, and the untransfected cell line CHO-K1 were used as EGFR-positive cells and -negative cells respectively in the subtractive selection procedure. A novel human anti-EGFR scFv (F4-scFv) was isolated. F4-scFv bound native EGFR-bearing cell lines and could be internalized, but did not bind EGFR-negative cell lines. The K(D) value of F4-scFv was 472 nM as determined on A431 cells. F4-scFv could be used to target therapeutic agents into tumour cells and was expected to be non-immunogenic in humans. Use of a transfected cell line expressing GFP-tagged receptors allows selection and characterization of antibodies to native receptors without the need for protein expression and purification, significantly speeding up the generation of targeting antibodies.

Animals↗

PubMed2006

Further quantification of the role of internal unstirred layers during the measurement of transport coefficients in giant internodes of Chara by a new stop-flow technique.

A new stop-flow technique was employed to quantify the impact of internal unstirred layers on the measurement of the solute permeability coefficient (P(s)) across the plasma membrane of internodes of the giant-celled alga Chara corallina using a cell pressure probe. During permeation experiments with rapidly permeating solutes (acetone, 2-propanol, and dimethylformamide), the solute concentration inside the cell was estimated and the external medium was adjusted to stop solute transport across the membrane, after which responses in turgor were measured. This allowed estimation of the solute concentration right at the membrane. Stop-flow experiments were also simulated with a computer. Both the stop-flow experiments and simulations provided quantitative data about internal concentration gradients and the contribution of unstirred layers to overall measured values of P(meas)(s) for the three solutes. The stop-flow experimental results agreed with stop-flow simulations assuming that solutes diffused into a completely stagnant cell interior. The effects of internal unstirred layers on the underestimation of membrane P(s) declined with decreasing P(s). They were no bigger than 37% in the presence of the most rapidly permeating solute, acetone (P(meas)(s) =4.2 x 10(-6) m s(-1)), and 14% for the less rapidly permeating dimethylformamide (P(meas)(s) =1.6x10(-6) m s(-1)). It is concluded that, even in the case of rapidly permeating solutes such as isotopic water and, even when making pessimistic assumptions about the internal mixing of solutes, an upper limit for the underestimation of P(s) due to internal unstirred layers was 37%. The data are discussed in terms of recent theoretical estimates of the effect of internal unstirred layers and in terms of some recent criticism of cell pressure probe measurements of water and solute transport coefficients. The current stop-flow data are in line with earlier estimations of the role of unstirred layers in the literature on cell water relations.

Biological Transport↗

PubMed2006

Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function.

Antibiotics can have a biological effect apart from their anti-bacterial effect. We hypothesized that doxycycline could attenuate acute lung injury through its biological effect. Lipopolysaccharide or doxycycline-resistant Streptococcus pneumoniae was administered intratracheally into mice with the co-administration of doxycycline. Thereafter, the lung pathology, intraalveolar inflammatory cells, bacterial number, and matrix metalloproteinases were investigated. Matrix metalloproteinases, neutrophil migration, and alveolar destruction were induced by lipopolysaccharide. Doxycycline was thus found to improve all of these symptoms. In addition, an inhibitor of matrix metalloproteinases, CGS27023A, attenuated lipopolysaccharide-induced lung injury. Doxycycline also attenuated the lung injury induced by doxycycline-resistant S. pneumoniae and improved the mortality rate although the bacterial number in the lung did not change. Our data indicated that doxycycline could attenuate acute lung injury through a biological effect that was different from its antibiotic effect.

Animals↗

PubMed2006

Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. The study of small molecule CCR8 antagonists will help establish the validation of these hypotheses. We report the design, synthesis, and progress toward optimization of potent small molecule CCR8 antagonists identified from a high-throughput screen. These analogues exhibit good potency in binding and chemotaxis assays, show good selectivity versus the hERG channel, and have good eADME (early absorption, distribution, metabolism, and excretion) profiles.

Amination↗

PubMed2006

Epidermal growth factor (EGF) induces apoptosis in a transfected cell line expressing EGF receptor on its membrane.

Interaction between epidermal growth factor (EGF) and EGF receptor (EGFR) promotes cell growth in most cell lines, but in a number of cell lines, EGF paradoxically inhibits proliferation. In the present study, we established a cell line expressing full-length human EGFR on membrane with a GFP fluorescence reporter at the C-terminal and studied the effects of EGF on cell proliferation in the transfected cell line. Our results suggested that low concentrations of EGF promoted proliferation, while high concentrations of EGF induced loss of adhesion, cell cycle arrest, apoptosis, and inhibition of proliferation. The effects of EGF on cell proliferation correlated well with the expression levels of EGFR. High concentrations of EGF induced both EGFR expression and apoptosis in a dose-dependent manner. Our study reported, for the first time, a relationship between the effects of EGF on cell proliferation and levels of EGFR expression in one cell line expressing different levels of EGFR caused by different concentrations of EGF treatment. The study should provide considerable insight into the effects of EGF on cell proliferation and tumor cell metastasis.

Animals↗

PubMed2006

Mortality among first-admission patients with psychosis.

OBJECTIVE: This study compared 5- and 10-year survival and absolute and relative mortality rates among first-admission patients with 1 of 4 psychotic disorders: schizophrenia/schizoaffective disorder, bipolar disorder, major depression, and other nonorganic psychoses. METHOD: The authors conducted a prospective 10-year follow-up of subjects first admitted with a diagnosis of nonorganic psychosis to any of 12 hospitals in Suffolk County, New York, during the period 1989 to 1995. Information on their death status since study entry was ascertained from the Social Security Death Index and the National Death Index. Survival analyses were conducted using the Kaplan-Meier product-limit estimator. RESULTS: There were no significant differences in survival rates among the 4 diagnostic groups at 5-year (range, 96.3%-97.8%) or 10-year (range, 90.2%-97.8%) follow-up. Absolute mortality over the study period ranged from 2.8% of bipolars to 6.7% of those with major depression. About 60% of deaths among schizophrenic/schizoaffective subjects were due to unnatural causes, whereas for the other 3 groups, deaths were more evenly split between natural and unnatural causes. Suicides comprised most deaths from unnatural causes, most of which occurred during the 2- to 5-year follow-up period. Deaths due to natural causes tended to be related to lifestyle factors. CONCLUSIONS: First-admission patients with psychosis experience similar patterns of mortality risk over the first 10 years after index admission regardless of underlying diagnosis. Causes of death (both natural and unnatural) were potentially preventable with more intensive medical and psychiatric follow-up and intervention. Many deaths from unnatural causes occurred during or shortly after discharge from an inpatient or residential treatment setting, highlighting this period as one needing close scrutiny by treating clinicians.

Affective Disorders, Psychotic↗

PubMed2006

In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI.

In vivo cell tracking by MRI can provide means to observe biological processes and monitor cell therapy directly. Immune cells, e.g., macrophages, play crucial roles in many pathophysiological processes, including organ rejection, inflammation, autoimmune diseases, cancer, atherosclerotic plaque formation, numerous neurological disorders, etc. The current gold standard for diagnosing and staging rejection after organ transplantation is biopsy, which is not only invasive, but also prone to sampling errors. Here, we report a noninvasive approach using MRI to detect graft rejection after solid organ transplantation. In addition, we present the feasibility of imaging individual macrophages in vivo by MRI in a rodent heterotopic working-heart transplantation model using a more sensitive contrast agent, the micrometer-sized paramagnetic iron oxide particle, as a methodology to detect acute cardiac rejection.

Animals↗

PubMed2006

Characterization of a single-chain variable fragment (scFv) antibody directed against the human asialoglycoprotein receptor.

To obtain scFv (single-chain variable fragment) against human ASGPR (asialoglycoprotein receptor), a human non-immune phage antibody library was screened with the recombinant CRD (carbohydrate recognition domain) of rCRDH1 (the H1 subunit of human ASGPR). Anti-rCRDH1 phage clones were obtained after four rounds of screening with rCRDH1-coated immunotubes and single positive colonies were further selected with the expressed thioredoxin-His-S tag of the wild-type pET32c. Two specific anti-rCRDH1 phage clones (named C1 and C2) were transfected into Escherichia coli HB2151 and induced for secreted expression of scFv antibody. The purified anti-rCRDH1 C1 and C2 single-chain antibodies were characterized by immunoblotting and immunohistochemistry. Both antibodies were found to specifically recognize denatured and native forms of the ASGPR and thus could potentially be used as targeting molecules for gene therapy of hepatocellular carcinoma or other liver diseases.

Amino Acid Sequence↗

PubMed2006

Oxidative gating of water channels (aquaporins) in corn roots.

An oxidative gating of water channels (aquaporins: AQPs) was observed in roots of corn seedlings as already found for the green alga Chara corallina. In the presence of 35 mM hydrogen peroxide (H2O2)--a precursor of hydroxyl radicals (*OH)--half times of water flow (as measured with the aid of pressure probes) increased at the level of both entire roots and individual cortical cells by factors of three and nine, respectively. This indicated decreases in the hydrostatic hydraulic conductivity of roots (Lp(hr)) and of cells (Lp(h)) by the same factors. Unlike other stresses, the plant hormone abscisic acid (ABA) had no ameliorative effect either on root LP(hr) or on cell Lp(h) when AQPs were inhibited by oxidative stress. Closure of AQPs reduced the permeability of acetone by factors of two in roots and 1.5 in cells. This indicated that AQPs were not ideally selective for water but allowed the passage of the organic solute acetone. In the presence of H2O2, channel closure caused anomalous (negative) osmosis at both the root and the cell level. This was interpreted by the fact that in the case of the rapidly permeating solute acetone, channel closure caused the solute to move faster than the water and the reflection coefficient (sigma s) reversed its sign. When H2O2 was removed from the medium, the effects were reversible, again at both the root and the cell level. The results provide evidence of oxidative gating of AQPs, which leads on to inhibition of water uptake by the roots. Possible mechanisms of the oxidative gating of AQPs induced by H2O2 (*OH) are discussed.

Abscisic Acid↗

PubMed2006

A re-examination of the minor role of unstirred layers during the measurement of transport coefficients of Chara corallina internodes with the cell pressure probe.

The impact of unstirred layers (USLs) during cell pressure probe experiments with Chara corallina internodes has been quantified. The results show that the hydraulic conductivity (Lp) measured in hydrostatic relaxations was not significantly affected by USLs even in the presence of high water flow intensities ('sweep-away effect'). During pressure clamp, there was a reversible reduction in Lp by 20%, which was explained by the constriction of water to aquaporins (AQPs) in the C. corallina membrane and a rapid diffusional equilibration of solutes in arrays where water protruded across AQPs. In osmotic experiments, Lp, and permeability (Ps) and reflection (sigma s) coefficients increased as external flow rate of medium increased, indicating some effects of external USLs. However, the effect was levelling off at 'usual' flow rates of 0.20-0.30 m s(-1) and in the presence of vigorous stirring by air bubbles, suggesting a maximum thickness of external USLs of around 30 microm including the cell wall. Because the diameters of internodes were around 1 mm, internal USLs could have played a significant or even a dominating role, at least in the presence of the rapidly permeating solutes used [acetone, 2-propanol and dimethylformamide (DMF)]. A comparison of calculated (diffusion kinetics) and of measured permeabilities indicated an upper limit of the contribution of USLs for the rapidly moving solute acetone of 29%, and of 15% for the less rapidly permeating DME The results throw some doubt on recent claims that in C. corallina, USLs rather than the cell membrane dominate solute uptake, at least for the most rapidly moving solute acetone.

Chara↗

PubMed2006

Hemodynamic support with the pulsatile catheter pump in a sheep model of acute heart failure.

This study was aimed to mimic clinical heart failure (HF) conditions and to assess the effect of pulsatile catheter (PUCA) pump support on hemodynamics and tissue perfusion in a sheep model of acute HF. In 14 sheep, HF was induced by partial occluding the middle left circumflex coronary artery combined with pacemaker-induced tachycardia. PUCA pump was then activated to support the HF for 3 h. Hemodynamic parameters were recorded at baseline, HF, and then every 30 min during experiments. Blood samples were taken in carotid artery (CA), pulmonary artery (PA), and coronary sinus (CS) for the determination of oxygen saturation (SO2) and lactate concentration as markers of tissue perfusion. Results showed that HF model was induced successfully in 10 sheep and failed in four sheep due to refractory ventricular fibrillation. PUCA pump support was successful in seven out of 10 sheep for 3 h. Three cases failed due to technical problems. After HF (n = 10), cardiac output (CO) was decreased from 3.7 +/- 0.5 to 2.0 +/- 0.5 L/min (P < 0.001). Mean arterial pressure (MAP) was lowered from 116.1 +/- 14.2 to 68.1 +/- 14.7 mm Hg (P < 0.001). In seven sheep supported with PUCA pump, MAP rose from 68.9 +/- 15.2 to 94.7 +/- 14.7 mm Hg (P = 0.005), systolic blood pressure increased from 86.6 +/- 17.0 to 112.6 +/- 17.1 mm Hg (P = 0.009), and diastolic blood pressure increased from 57.7 +/- 12.6 to 79.9 +/- 13.9 mm Hg (P = 0.011). CO remained at about 2.0 L/min. SO2 in CA, PA, and CS decreased significantly after HF (P < 0.001), with an increase after support (compared with HF, P < 0.001, 0.066 and 0.114, respectively). Lactate concentrations increased gradually in CA, PA, and CS toward the end of experiments without difference among different sampling sites. This HF model in sheep is simple, easy to manipulate, reproducible and reflecting clinical HF conditions. PUCA pump can maintain the hemodynamic status for 3 h in this acute HF model.

Acute Disease↗

PubMed2006

Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

Animals↗

PubMed2006

[A high sensitivity optical multichannel analyzer].

Noise sources of the CCD as the photoelectric detection device in an optical multichannel analyzer (OMA) were analyzed, and noise suppression methods were discussed. A high sensitivity OMA was developed successfully on the basis of the noise suppression techniques, and the 7th spectral lines of Balmer series of hydrogen and deuterium were resolved clearly by the OMA. Its sensitivity was enhanced by one order of magnitude, compared with those reported in the literatures. This OMA also showed high resolution, high precision and good reliability in the authors' experiments.

English Abstract↗

PubMed2006

[Impact of childhood abuses on the psychology and behaviors regarding harmful dietary pattern in adolescents].

OBJECTIVE: To examine the effect of childhood abuses on adolescents' psychology and behaviors related to harmful dietary pattern. METHODS: Anonymous questionnaire study on childhood abuses, adolescents' psychology and behaviors regarding their dietary patterns was conducted among 5141 students in 9 middle schools in 2 areas of Anhui province. RESULTS: Among 5141 students, 29.9% reported having severe childhood physical abuse, 64.8% having intermediate childhood physical abuse, 51.4% having mental abuse, 5.3% having physical contact sexual abuse and 24.5% having non-physical contact sexual abuse. In junior, senior middle schools and vocational schools, the incidence rate of severe childhood physical abuse, physical contact sexual abuse and non-physical contact sexual abuse among male students was higher than that among female students. In total, the incidence rate of childhood mental abuse among female students (53.1%) was higher than that among male students (49.8%) and with significant difference (chi2 = 5.484, P < 0.05). The incidence rate of 5 kinds of childhood abuses among junior middle school students was relatively low, and the incidence rate of intermediate childhood physical abuse and mental abuse was higher among senior middle school students. The incidence rate of 9 among the 11 kinds of psychology and behaviors related to harmful dietary pattern among female students in the middle schools and vocational schools was higher than that among male students. By unconditional multivariate logistic regression model, results showed that the childhood abuses was among the 11 kinds of psychological and behavioral risk factors related to harmful dietary pattern. CONCLUSION: Childhood abuses had negative effects on dietary behaviors in adolescents.

Adolescent↗

PubMed2006

[Cephalometric comparisons of the craniofacial characteristics of Class II 1 malocclusions with different vertical types in adolescences].

PURPOSE: To compare the craniofacial characteristics in Class II(1) malocclusions with different vertical types in adolescence. METHODS: The sample, including 60 males and 60 females, was divided into three groups equally based on their FMA degrees (high-angle group, average-angle group, low-angle group and normal occlusion group). Cephalograms were traced for all the subjects. Data were obtained to perform analysis of variance and LSD multiple range test. RESULTS: 1. The vertical growth of the anterior part of maxilla was greater than the posterior part in the three groups with Class II(1) malocclusion. The vertical dimension of the composite ramus-cranial floor was deficient relative to that of anterior maxilla in the high-angle and average-angle groups, the mandible rotated backward, especially in the high-angle group. In the low-angle group, the vertical dimension of the composite ramus-cranial floor grew excessively relative to that of posterior maxilla. The palatal plane and mandible plane rotated forward and upward. 2. The dentoalveolar characteristics of Class II(1) malocclusion group showed that: U6 tipped distally, the dentoalveolar height of L6 decreased, the functional occlusal plane (FOP) of average-angle group deviated away from the neutral occlusal axis (NOA), and rotated downward. In the high- angle group, the FOP deviated away from the NOA severely. The vertical dentoalveolar heights of U6 were normal. In the low-angle group, the vertical dentoalveolar heights of U6, the dentoalveolar height of L6 decreased, the angle of FOP between NOA showed no significantly difference from normal-occlusion group. CONCLUSION: There were different craniofacial vertical characteristics of Class II(1) malocclusion with different vertical types in adolescences. Different methods should be used to control the vertical dimensions in different types.

Adolescent↗

PubMed2006

[In vitro anti-tumor effect of CTL induced by HSP70-Id complex-modified dendritic cells].

OBJECTIVE: To prepare the tumor antigen peptide complex (HSP70-1d) of HSP70 and idiotype (Id) from SmIg ScFv fragment in patients with Chronic B cell leukemia (B-CLL), and to study the anti-tumor effect of cytotoxic T lymphocyte (CTL) induced by HSP70-Id complex-modified dendritic cell (DC) in vitro and explore their immune mechanism. METHODS: Purified HSP70 was combined into peptide complex (HSP70-Id) with the prepared Id-ScFv from B-CLL cells in vitro by using biochemical technique. The plastic-adherent monocytes from human peripheral blood were cultured and induced into DC with rhGM-CSF and rhIL-4 using cell culture and separation technique. The cultured DC were harvested and pulsed by HSP70-Id complex. DC morphology was observed under converted phase microscope and its phenotype was characterized by FCM on 8th day as well as their secreting cytokines were measured. Host lymphocytes were stimulated by DC loaded with HSP70-Id complex and co-cultured in the medium containing IL-2. The activation and proliferation of lymphocytes were examined by MTr test, which was also used to assay cytotoxicity of CTL elicited by modified DC to Daudi, K562 and HepG2 tumor cells, and FCM analyzed the changes of T lymphocyte subsets. RESULTS: Mature DCs were obtained successfully, showing typical morphology and phenotypic properties, the expression ratio of cellular surface molecules, CD1a was 20% - 30%, CD83 was more than 72% , both CD86 and HLA-DR over-expressed obviously in the complex-loaded DC group secreting cytokines of Thl type, IL-12 and TNF-alpha. The culturing lymphocytes that were activated by modified DC could more effectively and specifically kill Daudi (71. 24%), but not K562 and HepG2 tumor cells. Results of FCM assay demonstrated that percentage of CD4+ and CD8+ T lymphocytes cocultured with complex-modified DC increased notably to 56.51% and 70.21%, respectively. CD4+ T/ CD8+ T proportion was changed from 1.49 to 0.81. The dose of peptide would be reduced to 1/50 if specific CTL induced by complex-modified DC instead of directly by peptide complex. CONCLUSION: DCs modified by HSP70-Id complex exhibit powerful biological activities, and could induce CTL to specific cytotoxicity against carcinoma cells. It might be produced by cooperation of CD4+ T, CD8+ T lymphocytes and DC. The results also suggested that DC modified by HSP70-Id complex can present antigen and induce CTL with high efficacy and specificity.

Cell Line, Tumor↗

PubMed2006

[Correlation between psychopathological symptoms, coping style in adolescent and childhood repeated physical, emotional maltreatment].

OBJECTIVE: To study possible relationship between psychopathological symptoms, positive and negative coping styles in adolescents who experienced repeated serious childhood physical abuse (CPA), moderate CPA, and childhood emotional abuse (CEA). METHODS: A total of 5453 students were recruited as subjects from 9 middle schools at grades 7, 8, 10, and 11. They provided informed consent and participated in the self-administered anonymous survey on their frequencies of serious or moderate physical abuse and emotional abuse by his/her parents or other caregivers about average times of experiencing maltreatment every year during primary school. The Symptoms Checklist 90 (SCL-90) was used to rate general mental problem and 9 special psychopathological symptoms. The trait positive and negative coping styles were assessed with the Trait Coping Style Questionnaire (TCSQ). Totally 5141 respondents substantially completed surveys. It was defined as repeating childhood maltreatment that the adolescent reported he/she had suffered 3 or more episodes of one or more forms of serious CPA, moderate CPA, and CEA. Multinomial logistic regression model was used to analyze the effect of the types and quantities of repeating childhood experiences on mental health when the positive, negative coping styles, and both of them entered the statistics model, taking the demographic variables as covariates. RESULTS: Of respondents, 9.1 percent were rated as having general mental health problem. The rates of somatization, obsession, interpersonal susceptivity, depression, anxiety, phobia, paranoia, and psychotic symptoms were 1.3%, 3.6%, 3.6%, 2.8%, 2.2%, 4.0%, 2.1%, 2.8% and 1.6%, respectively. Dose-response trend existed between the number of items of repeating serious CPA, moderate CPA, CEA, and rates of general mental problems, 9 kinds of psychopathological symptoms, number of positive items of psychopathological symptoms. Compared with the respondents without serious CPA, moderate CPA or CEA, those with repeating childhood maltreatment had higher scores of negative coping styles. In the respondents with repeating childhood maltreatments, the prevalence of general mental problems and number of positive psychopathological symptoms increased with the rising of scores of negative coping styles. The results from multinomial logistic regression analysis showed that negative coping style decreased the odds ratio (OR) of repeating serious CPA, moderate CPA, and CEA with general mental health problems, but positive coping style did not. CONCLUSIONS: The experiences of repeating childhood physical or emotional maltreatment are associated with a wide variety of psychopathological symptoms and general mental health problems. Negative coping strategies may moderate the links of childhood abusive experiences and mental problems.

Adaptation, Psychological↗