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Biomedical subjects

R A Adams

Publications and source records attributed to R A Adams.

At least 55 records · Page 3Linked to original sources
PubMed1979

Cell populations in the transseptal fiber region before, during and after experimental periodontitis in squirrel monkeys.

A study was designed to enumerate cell populations before, during and after experimentally induced periodontitis in squirrel monkeys. The clinically healthy gingival connective tissue adjacent to the sulcus contained populations of macrophages, plasma cells, lymphoid cells, and granulocytes, indicating that immune responses were probably in operation. Although these cell populations have been associated with tissue destruction, it is possible that they may serve to confine the antigens to the tissue adjacent to the sulcus, and reduce their spread apically. Active periodontitis was associated with the presence of granulocytes and macrophages in the transseptal fiber region. These cells are capable of causing the localized collagen degradation and bone resorption that occur during the destructive phase of the disease. Eight weeks after etiologic agents were removed, the cell populations in the transseptal fiber area returned to a level comparable with those in the pre-experimental, clinically healthy. This indicates that active periodontitis within the transseptal fiber region had ceased and repair had occurred.

Animals↗
PubMed1978

An experimental approach to the breast cancer, reserpine problem.

Reserpine was administered intraperitoneally 3 times weekly to inbred female Syrian BIO hamsters of the 15.16 strain previously shown to be susceptible to methylcholanthrene (MC) induction of mammary cancer. Other groups of hamsters received non-carcinogenic doses of MC along with the reserpine administrations, and an additional group received a carcinogenic dose of MC alone. This last group demonstrated that BIO 15.6 females were indeed susceptible to MC mammary cancer induction, since 4 mg of MC administered by stomach tube (a total dose of 200 mg) caused mammary cancer in 52% of the animals. Mammary cancer was not observed in any of the animals given reserpine or reserpine in combination with the non-carcinogenic dose of MC.

Animals↗
PubMed1976

The clinical effectiveness of a disposable aspirating syringe.

In 18 per cent of mandibular block injections and 2 per cent of maxillary infiltrations blood appeared in the carpule aspiration. In 500 mandibular block injections when an aspirating syringe was used in 250, only 0.7 per cent patients suffered toxic side effects compared with 5 per cent when a conventional non-aspirating syringe was used.

Anesthesia, Dental↗
PubMed1970

Growth characteristics of virus-transformed cells. Maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability.

Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly, the altered characteristics here studied (escape from contact inhibition of growth and susceptibility to inhibition by other cells, decreased serum requirement, and ability to grow in soft agar) do not, in and of themselves, endow the cell with the capacity to produce a tumor, at least as judged by the methods of assay here used. Although the question as to whether the tumorigenicity of virus transformants is causally linked to any of these associated changes cannot be answered definitively, the evidence suggests a close linkage, rather than identity, between the determinants of oncogenicity and the other properties here studied.

Adenoviridae↗