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Biomedical subjects

R A Baughman

Publications and source records attributed to R A Baughman.

At least 55 records · Page 3Linked to original sources
PubMed1985

Gaucher's disease affecting the mandible.

A case of Gaucher's disease affecting the left body of the mandible is presented. Dentists can recognize this uncommon disease through the medical history of the patient, the presence of characteristic Gaucher cells on biopsy of the lesion, and decreased serum levels of the enzyme glucocerebrosidase.

Gaucher Disease↗
PubMed1984

Histologic appearance of the bilaminar zone in internal derangement of the temporomandibular joint.

Light microscopy was used to examine twenty-six specimens of bilaminar zone tissue excised during surgery for correction of internal derangement of the temporamandibular joint. Each of the specimens was examined for the presence of inflammation, amount of vascularity, arterial wall thickness, presence of fat, appearance of collagen, and amount of elastin present. Wide variation in the histologic appearance was noted among the specimens, although no significant inflammation was observed in any of them. Some indications that this tissue is undergoing adaptive changes include the presence of thickened arterial walls suggesting a decreased blood flow and the tendency for decreased amounts of elastin to be associated with denser-appearing collagen. There is also a tendency for patients with complete dislocation to exhibit less elastin than those with partial dislocation of the meniscus.

Adolescent↗
PubMed1980

Altered prazosin pharmacokinetics in congestive heart failure.

The pharmacokinetics of prazosin (Minipress) were studied in nine patients with NYHA Class 3 or 4 congestive heart failure and in five healthy controls. After a single 5 mg oral dose, plasma concentrations of prazosin, as reflected in the area under the plasma concentration-time curve (AUC) and prazosin plasma half-life, were approximately double in the patients in comparison to the control group. Reduction in hepatic blood flow, altered gastrointestinal absorption of the drug or diminished intrinsic hepatic metabolic activity in the patient group may have contributed to the observed changes in prazosin disposition. The finding of higher prazosin plasma concentrations in patients with refractory heart failure demonstrates the need for close monitoring of these individuals following administration of the drug in the treatment of chronic congestive heart failure.

Adult↗
PubMed1980

The oral hair: an extremely rare phenomenon.

A proven case of true hair occurring naturally in the mouth has been reported only once previously. A second case of this rare anomaly is reported here. In this case a single hair was found at the base of the attached gingiva in the mandibular cuspid region of a 45-year old white man.

Gingiva↗
PubMed1980

A survey of panoramic radiographs for evaluation of normal and pathologic findings.

Six thousand seven hundred eighty panoramic radiographs were screened to monitor the incidence of normal and pathologic findings. Three different types of panoramic radiograph were used in this study: Panorex, Orthopantomograph, and Panelipse. Visualization of four different anatomic landmarks was used for a statistical comparison of the diagnostic value of the three films: the temporomandibular joint compartments, the external oblique ridge, the mental foramen, and the mandibular canal. The orthopantomograph was judged to be slightly more reliable in producing radiographs for the visualization of the selected anatomic structures. The most common form of pathosis detected was impacted teeth, seen in 22.3 percent followed by retained roots, which appeared in 12.6 percent of the films. Comparing these survey data with three other major studies suggests that confining the previous radiographic examinations to certain selected groups of people may have distorted the incidence of some pathologic conditions in the population. The panoramic radiograph is still considered a supplement to, not a substitute for, the intraoral radiograph.

Humans↗
PubMed1980

Prepubertal oral pemphigus vulgaris.

Although rare, oral pemphigus vulgaris must be considered in those patients who have a prolonged history of oral lesions. The fact that chronic oral lesions characteristically precede skin changes in pemphigus emphasizes the importance of this disease to the dental profession. Patients with long-term and recurrent vesiculoulcerative oral lesions should undergo biopsy examination to establish the diagnosis. The dentist and the physician must collaborate to establish an appropriate diagnostic and therapeutic plan for the management of these patients.

Blister↗
PubMed1979

Chievitz's organ: a potential pitfall in oral cancer diagnosis.

It has been reported that epithelial nests associated with sensory nerve fibers may simulate perineural invasion and pose a potential diagnostic problem for surgical pathologists working on frozen tissue specimens from patients with oral cancer. The epithelial structures are not neoplastic, and no known pathologic condition has been associated with them. They are believed to be those structures described scantily in the English literature as Chievitz's organ. The fact that the epithelial nests lie near the plane of injection for the inferior alveolar nerve should be of special interest to dentists, especially oral surgeons and pathologists. Controversy exists as to the exact nature of Chievitz's organ, but the potential hazard of misdiagnosis exists nonetheless. This study of cadaver and autopsy material reaffirms the existence of the epithelial rests and outlines a simple technique for locating them.

Aged↗
PubMed1979

Attenuation of prazosin effect on cardiac output in chronic heart failure.

The persistence of the hemodynamic effects of prazosin was studied in 12 patients with chronic congestive heart failure. Multidose evaluation involving five 5-mg doses showed the initial decrease in systemic vascular resistance and increase in cardiac index, stroke work index, and stroke volume index to be transient. Doubling the dose did not restore effect. Modest decreases in pulmonary capillary-wedge and mean arterial pressures persisted throughout the study. In six patients, plasma prazosin concentration measured at times of hemodynamic observations showed the initial hemodynamic effect of prazosin to attenuate upon further administration despite mean plasma concentrations that exceeded those measured after the first dose. In patients with chronic heart failure, resting hemodynamic studies suggest a rapid attenuation of prazosin-mediated hemodynamic effect in the presence of adequate plasma concentration. Recognizing this phenomenon, if long-term prazosin therapy for congestive heart failure is contemplated, we suggest the hemodynamic response in individual patients be monitored.

Adult↗