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Biomedical subjects

R A Bourne

Publications and source records attributed to R A Bourne.

9 recordsLinked to original sources
PubMed1988

Obese hypoventilation syndrome of early childhood requiring ventilatory support.

In December 1986 a 30-month-old female child with morbid obesity and respiratory failure was admitted to the Izaak Walton Killam Hospital for Children in Halifax. The etiology of the obesity was found to be dietary in origin after ruling out genetic, neurological and metabolic causes. This patient exhibited somnolence and cyanosis in association with hypercapnia and right ventricular overload. Her respiratory failure in the presence of a normal upper airway required ventilatory support, first with nasal endotracheal intubation, and then, tracheotomy. Weight reduction normalized her capillary blood gases and her somnolence disappeared. Subglottic stenosis hampered removal of the tracheotomy tube until 9 months after admission. The pathogenesis and management of obese hypoventilation syndrome are reviewed by the authors.

Child, Preschool↗
PubMed1977

Serum growth hormone concentrations after growth hormone or thyrotropin releasing hormone in cows.

A single subcutaneous injection of 10, 50, or 100 mg bovine growth hormone into lactating Holstein cows increased concentrations of growth hormone, insulin, and glucose in serum above preinjection baselines for at least 16 h. Growth hormone concentrations in serum after injection of growth hormone or thyrotropin-releasing hormone were greater in cows during early (2 to 4 mo) as compared with cows during late (8 to 12 mo) lactation. Stage of lactation did not affect rate of metabolic clearance of growth hormone in eight cows, but larger cows cleared growth hormone more rapidly than smaller cows. Data of these experiments may help to explain how injections of growth hormone every 3 days stimulate milk yields.

Animals↗
PubMed1975

Serum prolactin and LH responses to photoperiod in bull calves.

Two bull calves were subjected to changes in daily illumination over a 12-week interval, with ambient temperature maintained at 22 C. When photoperiod was shortened from 16 to 8 h, serum prolactin decreased from a maximum of 57 mg/ml to a minimum of 8 ng/ml. Conversely, with another 4 bulls, increasing the photoperiod from 8 to 16 h of light caused serum prolactin concentrations to increase from 25 to 100 ng/ml. The increase in serum prolactin in response to increasing photoperiod was delayed approximately 7 weeks, whereas the response to decreasing photoperiod was delayed only about 1 week. Changes in photoperiod had no effect on serum LH concentrations. We conclude that changes in photoperiod account, at least partially, for the seasonal changes in serum prolactin previously noted in cattle.

Animals↗