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Biomedical subjects

R A Brower

Publications and source records attributed to R A Brower.

8 recordsLinked to original sources
PubMed1988

Collagenous colitis: an association with fecal leukocytes.

Collagenous colitis is an idiopathic inflammatory disorder of the colon associated with watery diarrhea, minimal to normal endoscopic findings, and a pathognomonic subepithelial band of collagen. This band is associated with a mucosal, acute and chronic inflammatory infiltrate. During the evaluation of four cases of collagenous colitis, we noted a remarkable number of acute inflammatory cells in the stool. This association has not been well recognized and carries important diagnostic significance because the mucosal appearance of the colon is frequently normal and nondiagnostic biopsies can occur early in the course of the disease or if obtained from the rectum. These cases suggest that collagenous colitis should be added to the differential diagnosis of diarrhea where fecal leukocytes are present.

Adult↗
PubMed1987

Spontaneous bacterial peritonitis in Wilson's disease.

Spontaneous bacterial peritonitis associated with Wilson's disease has been previously reported in only one case. We report two cases where this infection developed and seriously complicated the course of illness. As with spontaneous bacterial peritonitis occurring with other underlying diseases, early diagnosis and treatment are critical to improved outcome. Recognition that it can occur with Wilson's disease is important, and paracentesis should be performed without delay when suspicious features are present.

Adult↗
PubMed1986

Jejunal perforation possibly induced by slow-release potassium in a patient with Crohn's disease.

A case of small bowel ulceration and perforation possibly due to therapy with Klotrix in a patient with Crohn's disease is presented. Following emergent surgery with creation of a diverting loop jejunostomy, subsequent reestablishment of intestinal continuity was carried out with excellent clinical results. Gastrointestinal mucosal lesions possibly due to wax-matrix potassium chloride preparations are reviewed.

Crohn Disease↗
PubMed1983

Sensitivity of guaiac-impregnated cards for the detection of colorectal neoplasia.

The sensitivity of the guaiac-impregnated card, hemoccult II, for the detection of colorectal neoplasia was tested in 213 patients undergoing elective colonoscopy over a 10-month period. Contrary to statements in standard texts as to the high sensitivity of guaiac-impregnated cards for the detection of these tumors, our results demonstrate only a 52% sensitivity for colorectal carcinoma and a 23% sensitivity for adenomatous polyps over 1.0 cm in diameter. We compare these results to other studies testing hemoccult sensitivity in the presence of colorectal neoplasia. This relatively low sensitivity rate emphasizes that the use of guaiac-impregnated cards alone does not exclude colorectal carcinoma in any patient.

Adult↗