Biomedical subjects
Publications and source records attributed to R A Calloway.
The effect of steady state therapeutic theophylline serum levels on lithium renal clearance was investigated. Group mean lithium renal clearances and serum lithium levels varied in predicted fashion. Individual variability in these parameters was significant. Clinical implications are considered and management suggestions made.
The effect of steady state therapeutic theophylline serum levels on lithium clearance was investigated. A significant increase in lithium clearance occurred with the administration of theophylline. Despite considerable intersubject variability, a direct lithium clearance estimation method demonstrated a mean increase of 30% with the addition of theophylline. The concomitant use of lithium and theophylline potentially may alter lithium levels sufficiently to result in manic or depressive relapses in patients receiving lithium prophylactically.