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Biomedical subjects

R A Cook

Publications and source records attributed to R A Cook.

62 records · Page 4Linked to original sources
PubMedDate not supplied

Otodental dysplasia: a five year study.

Peripheral auditory sensitivity is documented over a 5-year period on 4 cases with otodental dysplasia. Age of onset is noted for the proband and indicates that onset of this progressive hearing loss occurs as early as the first decade. Findings suggest that the hearing loss plateaus by the fourth decade, resulting in a severe, flat, bilaterally symmetrical sensorineural hearing loss. The audiometric configurations are similar in all affected members of the kindred evaluated. Speech discrimination scores of the observed magnitude are somewhat uncharacteristic for the type and degree of impairment observed. Differential diagnostic audiometric test results suggest a cochlear site of lesion.

Audiometry, Pure-Tone↗
PubMedDate not supplied

Total ankle arthroplasty.

Ankle arthritis has traditionally been treated surgically with arthrodesis (fusion) after conservative measures have been exhausted. The success of joint arthroplasty in the knee, hip, and shoulder inspired many attempts over the past 30 years to construct a workable ankle prosthesis. The failures of first generation prostheses caused skepticism regarding the feasibility of total ankle arthroplasty (TAR), but the mistakes of the past have been transformed into improvements and modifications. Today's second generation total ankle designs show promise, and outcomes are encouraging. The Agility Ankle (DePuy, Warsaw, IN) designed by Dr. Frank Alvine is featured in this article. The method of implant and postoperative management are reviewed.

Ankle Joint↗
PubMedDate not supplied

Initial characterization of factors from testicular fluid which alter in vitro androgen secretion by normal rat Leydig cells.

It is known that testicular interstitial fluid (TF) contains thermolabile factors that can alter in vitro production of androgens by the Leydig cells. The net stimulatory activity of this fluid increases in association with the disruption of spermatogenesis. The identity of the active agent(s) in TF is not known. Therefore, the authors used gel-liquid chromatography to initially characterize TF from control and bilaterally cryptorchid animals. The stimulatory activity of TF was retained on Concanavalin A Sepharose columns. Gel filtration on Ultrogel AcA 44 suggested a molecular size between 40 and 90 kD. The unfractionated fluid from control and bilaterally cryptorchid rats, as well as the chromatographic fractions containing stimulatory activity, were further resolved by SDS-PAG electrophoresis. At least three bands representing glycoproteins with apparent molecular size between 57 and 75 kD were seen in all samples containing stimulatory activity. No difference in the pattern of protein bands was seen between TF from control and bilaterally cryptorchid testes. However, samples reduced with beta-mercaptoethanol showed protein bands with apparent molecular size of 78 and 118 kD which were present only in unpurified control TF. These data support the possibility that the stimulatory substance in TF from control and bilaterally cryptorchid testes is a glycoprotein with a molecular size between 57 and 75 kD. Differences in the bioactivity of the unfractionated TF may be due in part to the presence of additional larger protein molecules in the control TF.

Androgens↗