Letter to the editor: A field trial to evaluate an intranasal infectious bovine rhinotracheitis vaccine.
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Biomedical subjects
Publications and source records attributed to R A Curtis.
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A severe gastroenteritis affected Ontario pigs in the Spring of 1964 and again in 1966. The mortality of pigs less than a week of age was 100%, in older pigs there were few deaths although morbidity in these pigs approximated 100%. Viruses were isolated from the brains, intestines, and intestinal lymph nodes of baby pigs. One of these isolates, given by mouth to two colostrum deprived piglets, induced a severe enteritis 36 hours after administration and both of the piglets died 24 hours later. The characteristics of the disease and the virus bear a striking resemblance to transmissible gastroenteritis as seen in the United States of America and the United Kingdom.
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The National Institute for Occupational Safety and Health (NIOSH) investigated the health effects of chronic exposure to low concentrations of carbon monoxide by conducting a historical prospective cohort study of mortality patterns among 1,558 white male motor vehicle examiners who were employed in New Jersey for a minimum of 6 months between 1944 and 1973. Industrial hygiene surveys indicated that the examiners were exposed to carbon monoxide at a time-weighted average (TWA) of 10-24 ppm; the exposure level recommended by NIOSH is 35 ppm TWA. A modified life table technique was used to calculate cause-specific expected deaths for the cohort adjusted for age and calendar time periods. The expected deaths were compared to the number of observed deaths through August 1973. The cohort demonstrated a slight overall increase in cardiovascular disease deaths (124 observed vs. 118.4 expected), but a more pronounced excess was observed within the first 10 yr. following employment (28 observed vs. 20.9 expected). A statistically significant excess of cancer mortality was found for motor vehicle examiners after 30 yr latency (13 observed vs. 6.9 expected, P < 0.5); this excess, however, was not confined to any particular organ site. The number of deaths due to accidents was significantly lower than expected (8 observed vs. 19.6 expected, P < .01).
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