Biomedical subjects
Publications and source records attributed to R A Dmitrieva.
The article is dedicated to present-day problems of sanitary-virologic monitoring of water with different degree of pollution. The authors assess some indirect indicators of viral contamination of water and present perfected methods of water monitoring such as PCR, OT-PCR, and OT-PCR integrated with tissue culture for detecting viral RNA and DNA.
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Bound chlorine in doses 0.8-1.2 mg/l does not inactivate viruses in water. Chlorine can be active against hepatitis A viruses in concentration not less than 4.2 mg/l with the virion content in water 10(5)/ml and at least 20 min exposure.
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It has been found out that a coli-phage is a more reliable indirect indicator of viral pollution of drinking water that the existing indirect bacterial indicators. Coli-phages concentration in drinking water on the level of single PFU/1 is evidence of disturbances in the barrier function of water-treatment facilities with respect to viral microflora and of the possible epidemic danger of water with respect to viral infection. The absence of coli-phages in I 1 of water sample should be considered the standard level of coli-phages of drinking water.
An experimental evaluation of the impact of a number of chemical compounds toxicologically attributed to different hazardous classes on animal resistibility to influenza virus showed that resistibility dependence on the dose and effect duration had a nonlinear character. There was no complete correlation of a hazardous class of chemical substances and their impact on body resistibility to respiratory infections.
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