Biomedical subjects

R A El-Azhary

Publications and source records attributed to R A El-Azhary.

4 recordsLinked to original sources

PubMed2003

Cutaneous T-cell lymphoma and atopy: is there an association?

BACKGROUND: Case reports have suggested a relationship between atopic diatheses and Sézary syndrome, pre-Sézary syndrome or mycosis fungoides. However, Sézary and pre-Sézary syndromes are rare entities, and this association has never been analysed in greater detail for specific subtypes of cutaneous T-cell lymphoma (CTCL). OBJECTIVES: To evaluate the prevalence of atopy in subjects with Sézary syndrome, pre-Sézary syndrome or mycosis fungoides, and to compare the rates with the reported prevalence of atopy in the general population. METHODS: We retrospectively reviewed the records of 157 patients with the diagnosis of Sézary or pre-Sézary syndrome seen between 1965 and 2000, and 102 patients with the diagnosis of mycosis fungoides evaluated from 1994 to 2000 at Mayo Clinic. RESULTS: Of 157 subjects with Sézary or pre-Sézary syndrome and 102 subjects with mycosis fungoides, 18 and 12, respectively, were identified as having a history of atopic dermatitis, asthma or allergic rhinitis. The prevalence rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides were 11.5% (95% confidence interval 6.9-17.5%) and 11.8% (6.2-19.7%), respectively. CONCLUSIONS: No significant difference exists in the prevalence of atopy in Sézary or pre-Sézary syndrome compared with that in mycosis fungoides (chi2-test, P = 1.00). Furthermore, the rates of atopy in Sézary or pre-Sézary syndrome and mycosis fungoides are not significantly different from the prevalence of atopy in the general population (17-40%). On the basis of these observations, no evidence currently implicates a causal association of CTCL with atopy.

Asthma↗

PubMed2001

Sporotrichosis masquerading as pyoderma gangrenosum: case report and review of 19 cases of sporotrichosis.

We present the case of a 59-year-old woman who had large ulcerations on her right leg that were diagnosed initially as pyoderma gangrenosum and treated with three immunosuppressive agents (cyclosporin, prednisone and azathioprine) for 6 months. Results of a biopsy at 6 months showed numerous cigar-shaped bodies consistent with Sporothrix schenckii; identification was confirmed by tissue culture. A retrospective review was performed for all cases diagnosed as sporotrichosis from tissue culture or biopsy specimens at the Mayo Clinic. Nineteen cases were identified. The present case was the only one in which fungal organisms were visible on histological examination. The present case emphasizes the importance of making a definitive histological diagnosis in unusual ulcer cases or in suspected cases of pyoderma gangrenosum before the initiation of immunosuppressive therapy. The large number of cigar-shaped bodies in the tissue is a rare finding in sporothrix infection and has been reported in only two cases previously.

Biopsy, Needle↗

PubMed1998

Polyarticular blastomycotic arthritis.

Blastomycotic arthritis usually presents as acute monoarticular septic arthritis resembling a bacterial process. Only 2 cases in the literature have subsequently developed arthritis in a second joint. We describe the case of an elderly woman with polyarticular blastomycotic arthritis associated with lung, skin, and bone involvement. The organism was identified in the synovial fluid and skin biopsies. Our patient underwent open drainage and aspiration of the involved joints and received antimycotic therapy.

Aged↗

PubMed1982

Effect of melphalan on delta-aminolevulinic acid synthetase in the spleen, bone marrow and liver of rats.

The effect of melphalan, an antineoplastic alkylating agent, on the activity of delta-aminolevulinic acid synthetase (ALA-S) was studied. When given in a single oral dose (20 mg/kg) to male rats. ALA-S activity in the spleen rapidly declined, reaching 9% of controls 7 days after administration. A return to control values occurred after 10 days, followed by a rebound increase in activity to 180% of controls at day 15. After melphalan administration, a gradual loss in spleen weight was observed until day 10, followed by a rebound increase in spleen weight at day 15. Spleen heme oxygenase activity was induced to 243% of controls 7 days after melphalan administration. However, by 20 days the activity was only 55% above controls. Bone marrow ALA-S activity declined to 38% of controls 3 days after treatment, followed by a return to controls after 7 days. The return to control values at day 15 was accompanied by a shift in the differential white blood cell count to the segmented form. Red blood cell counts and hemoglobin content were decreased to 77% of controls at day 7. Liver ALA-S was not appreciably affected by melphalan except for a decrease to 56% of controls at day 7. It is concluded that melphalan depresses the level of activity of the erythroid form of ALA-S in spleen and bone marrow but has less effect upon the level of activity of the nonerythroid form in the liver.

5-Aminolevulinate Synthetase↗