Biomedical subjects

R A Esin

Publications and source records attributed to R A Esin.

5 recordsLinked to original sources

PubMed1999

Lung function status of some Nigerian men and women chronically exposed to fish drying using burning firewood.

OBJECTIVE: To determine the lung function status of some Nigerian men and women chronically exposed to fish drying using burning firewood. DESIGN: Case control study. SETTING: Ibaka, Utaewa and Ikanga fishing settlements. SUBJECTS: 183 males and 192 females engaged in fishing, aged 20 to 45 years who have been exposed for a minimum of five years as cases. The control group comprised sex matched male (142) and female (152) Nigerians from the same area who were not exposed to any known air pollutant. MAIN OUTCOME MEASURES: Lung function indices: FVC, FEV1, FEV1% and PEFR. RESULTS: Lung function indices were significantly lower in men engaged in fishing than in their controls: FVC [mean (SD): 2.98 (0.20) vs 3.52 (0.29), p < 0.001]; FEV1 [2.08 (0.18) vs 2.82 (0.25), p < 0.001]; FEV1% [69.8 (3.1) vs 80.2 (6.7), p < 0.001]; and PEFR [335 (22) vs 592 (99), p < 0.001], respectively. Similarly, lung function indices were lower in females in the fishing industry than in their controls; FVC [2.42 (0.17) vs 3.02 (0.24), p < 0.001]; FEV1 [1.70 (0.19) vs 2.55 (0.21), p < 0.001]; FEV1% [72.9 (3.2) vs 84.4 (6.7), p < 0.001]; and PEFR [298 (22) vs 418 (34), p < 0.001]. All the lung function indices (except FEV1%) of the fishermen and women declined significantly (p < 0.001) with their duration of exposure. The results showed a predominantly mixed pattern (restrictive and obstructive) of respiratory defect. There were higher prevalences of respiratory and other symptoms among the cases than the controls. The respiratory symptoms included cough with sputum, chest pain, dyspnoea catarrh and sneezing and unproductive cough. Other symptoms were eye and skin irritation, internal heat and headache. CONCLUSIONS: Chronic exposure to fish drying using burning firewood can impair lung function and cause respiratory and other symptoms.

Adult↗

PubMed1998

Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria.

There should be a recognisable trend between the incidence of hypereosinophilia and the duration of tropical endomyocardial fibrosis (EMF), if the hypothesis, that EMF is the burnt out phase of eosinophil associated heart disease, is correct. We tested this hypothesis in a prospective study of 89 consecutive EMF cases over an 18 year period at two Nigerian locations (Ife in South West and Calabar in South East). We carefully dated the duration of EMF symptoms at first presentation and screened for hypereosinophilia (eosinophilia > or = 1500/mm3), and their causes. When no cause was identified for hypereosinophilia we gave a therapeutic trial with diethylcarbamazine to the patients. An eosinophil count > or = 1000/mm3 was recorded in 80% of 24 cases seen within 6 months; 55% of 46 cases seen 0-24 months; 54% of 18 cases seen 25-48 months and 21% of 25 cases seen more than 49 months of onset of symptoms: while the respective distribution of eosinophil count > or = 1500/mm3 for similar periods were 66, 44, 27 and 21%. This reflects a highly significant (P < 0.001) inverse relationship between hypereosinophilia and the duration of EMF and strengthens the concept that EMF (without eosinophilia) represents the late stage of eosinophilic heart disease. The localisation of endemic EMF to the low-lying tropical rain forest Zone and its predominant occurrence among rural dwellers and farmers suggest a vector borne etiologic agent. Microfilaria was the most likely cause of hypereosinophilia in the cases presented.

Adolescent↗

PubMed1998

Acute bacterial meningitis in a developing country: diagnosis related mortality among paediatric patients.

OBJECTIVES: To evaluate the effect of late diagnosis and other factors on outcome of paediatric bacterial meningitis (BM) and recommend appropriate intervention. DESIGN: Case series. SETTING: University of Calabar Teaching Hospital, Calabar, Nigeria. SUBJECTS: 62 consecutive BM patients aged two months to 16 years admitted between 1991 and 1994. MAIN OUTCOME MEASURES: Mortality rate. RESULTS: Diagnostic difficulties experienced in 58% of cases and other factors resulted in delayed diagnosis and high mortality (20 to 47%). CONCLUSION: Only elimination of the identified inadequacies in management can significantly reduce the BM-related high mortality in developing countries.

Acute Disease↗

PubMed1996

Lung function studies in some Nigerian bank workers.

Following complaints of cough and tightness in the chest by a group of treasury workers exposed to large quantities of old and dirty currency notes withdrawn from circulation as well as currency for circulation, lung function tests were performed to find the effects of this exposure on the ventilatory function status of the workers. Lung function tests were carried out on 72 treasury workers (62 male and 10 female) aged 35.11 +/- 0.62 years (mean +/- SEM); range: (21 to 58 years), height 1.68 +/- 0.17 m; (1.55 to 1.97 m) and body weight 60.61 +/- 0.65 kg; (48 to 86 kg). The values were compared with a control group of age, height, weight and sex-matched Nigerians from the same area that were not exposed to any known air pollutant. The mean measured lung function values of the female workers were not significantly different from their control values. However, the mean measured values of FVC, FEV1 and PEFR of the males were significantly lower than their control values (p < 0.01; 0.05 and 0.001 respectively) which is indicative of a general restrictive ventilatory defect. We conclude that chronic exposure to large quantities of old and dirty currency notes withdrawn from circulation as well as new ones may impair the lung function of treasury workers.

Adult↗

PubMed1992

Ventilatory function in Nigerian asbestos factory workers.

Ventilatory function indices; forced vital capacity (FVC), forced expiratory volume in one second (FEV1), the percentage of vital capacity in one second (FEV1%) and peak expiratory flow rate (PEFR) were measured to find the effect of asbestos fiber on lung function in 95 male Nigerian asbestos factory workers (aged 25-55 years). The results were compared with a control group of age and sex-matched Nigerians from the same area that were not exposed to asbestos fiber or any known air pollutant. The results were also compared with expected values calculated from linear regression equations worked out for healthy Nigerians. The mean values of FVC, FEV1 and PEFR were significantly lower in the asbestos factory workers than in the control group (P less than 0.01, 0.05 and 0.001 respectively). FEV1 in asbestos factory workers showed a statistically significant negative correlation with the duration of service (P less than 0.05). The reduced FVC and FEV1 and normal FEV1% in asbestos factory workers is indicative of restrictive lung defect and may be attributed to asbestos fiber exposure. Frequent monitoring of the health of these factory workers and control measures should be stepped up in the factory.

Adult↗