Biomedical subjects

R A Garneau

Publications and source records attributed to R A Garneau.

3 recordsLinked to original sources

PubMed1991

Glenoid labrum: evaluation with MR imaging.

Fifteen patients with shoulder instability and nine asymptomatic volunteers were studied with magnetic resonance (MR) imaging. The shoulder joint was visualized by means of arthroscopy or surgery in all patients. Ten patients had abnormalities of the glenoid labrum. Two musculoskeletal radiologists interpreted the MR images of the patients and volunteers without knowledge of the clinical history or surgical results. The surgical and arthroscopic results were used as the standard of reference in symptomatic patients. Observer A achieved a sensitivity of 44.4% and a specificity of 66.7%; observer B had a sensitivity of 77.8% and a specificity of 66.7%. In addition to the poor sensitivities and specificities, there was substantial intra- and interobserver variability. Assuming that the shoulders of the asymptomatic volunteers were normal, the specificities were 100.0% and 88.9% for observers A and B respectively. In this small study, axial MR imaging was relatively insensitive and nonspecific in the evaluation of labral lesions. Further study will be necessary to determine the utility and limits of MR imaging in this regard.

Adolescent↗

PubMed1990

Clinical and radiologic features of malignant neoplasms in organ transplant recipients: cyclosporine-treated vs untreated patients.

The radiologic and clinical features of 37 posttransplantation malignant tumors occurring in 33 organ transplant recipients were reviewed to determine the characteristics of the tumors, particularly in relation to previous treatment (or nontreatment) with cyclosporine. The 37 malignant tumors included lymphomas (eight in patients receiving cyclosporine and four in patients not given cyclosporine) and carcinomas of the skin and lips (11), head and neck (five), colon and rectum (three), uterus (two), vulva (two), lung (one), and urinary bladder (one). The neoplasms of the internal viscera and head and neck were relatively advanced when detected. The neoplasms of the skin, vulva, uterine cervix, and urinary bladder were low-grade malignant tumors. Most of the cyclosporine-induced malignant lesions were lymphomas. The lymphomas in cyclosporine-treated recipients were characterized by early appearance after transplantation; more extensive organ involvement; multiple, homogeneous solid lesions without central low density on CT and sonography; and regression after reduction of cyclosporine dose. We conclude that malignant tumors occurring after transplantation are often advanced and that lymphoma induced by cyclosporine has characteristic features.

Adult↗

PubMedDate not supplied

Gadoteridol dose dependence in MR imaging of a liver abscess model.

A necrotic liver abscess model was studied with magnetic resonance (MR) imaging at 1.5 T before and after intravenous administration of gadoteridol at doses of 0.1, 0.25, and 0.5 mmol/kg in 24 rabbits. Enhancement characteristics and lesion delineation were assessed with both breath-hold and non-breath-hold imaging techniques. Lesion delineation, as assessed both by signal intensity measurements and evaluations by two image readers blinded to imaging technique, was greatest on high-dose (0.5 mmol/kg) breath-hold images. Lesion rim enhancement was seen consistently only on postcontrast images obtained at a dose of 0.5 mmol/kg and progressed with time after injection of contrast material.

Animals↗