Biomedical subjects
Publications and source records attributed to R A Hardie.
Naevoid hypertrichosis is an unusual congenital disorder consisting of a solitary circumscribed area of terminal hair growth which is not associated with any other systemic abnormalities. We describe a patient with multiple areas of circumscribed naevoid hypertrichosis on the trunk and limbs who also had lipodystrophy at some affected sites.
Explore the source record for details and available documents.
Lichen myxoedematosus was diagnosed in a 44-year-old woman in 1957. Despite the persistence of an abnormal serum protein, the skin lesions cleared by 1965. The protein abnormality disappeared several years later.
The enzymes of haem biosynthesis have been measured in the peripheral blood of 13 patients with cutaneous hepatic porphyria. The activity of leucocyte delta-aminolaevulinic acid synthase was significantly elevated (p less than 0.001) as was that of erythrocyte porphobilinogen deaminase (p less than 0.05). Leucocyte ferrochelatase activity was depressed (p less than 0.001) and the activity of erythrocyte uroporphyrinogen decarboxylase did not significantly differ from control values. Similar enzyme activities were assayed in 12 chronic alcoholics and 8 patients with liver disease and the results differed markedly from those obtained from the porphyric patients. It is unlikely that the raised leucocyte delta-amino-laevulinic acid synthase activity can be attributed to alcohol ingestion or liver disease. A defect in the activity of uroporphyrinogen decarboxylase may exist in cutaneous hepatic porphyria but this could not be demonstrated in erythrocytes in this study.
Explore the source record for details and available documents.
A case is presented of multiseptate hypoplastic gallbladder, which is an extremely rare combination of two congenital anomalies. The patient was diagnosed as having cholecystitis and was relieved of her symptoms following cholecystectomy, even though the specimen did not show evidence of inflammation or calculi. The significance of this is emphasized by reviewing the 5 authenticated cases of multiseptate gallbladder reported in the literature. Awareness of this condition should avoid misinterpretation of cholecystograms.
Explore the source record for details and available documents.
Explore the source record for details and available documents.