The in vivo experiments showed that insulin intensifies the threonine absorption and Na+ counterflow in the rat small intestine. Fluorine inhibits considerably the threonine absorption. The possible mechanism of the insulin and fluorine opposite effects on the threonine absorption in the small intestine is under discussion.

Animals↗

PubMedDate not supplied

[Effect of fluoride and insulin on cation-dependent ATPase activity of the enterocytes during threonine absorption].

Absorption of threonine was accompanied by a distinct increase in total activity of Mg2+- and Na+, K+-ATPases in rat small intestine. Sodium fluoride inhibited completely the Na+, K+-ATPase activity. After administration of insulin, activity of Na+, K+-ATPase was increased 2-fold without loading with threonine, and it was increased 3.3-fold in the amino acid loading. Sodium fluoride activated Mg2+-ATPase, insulin did not affect the enzyme activity but the hormone decreased partially the inhibitory effect of sodium fluoride on Na+, K+-ATPase.

Adenosine Triphosphatases↗

PubMedDate not supplied

[Change in the intensity of amino acid transport and electrolyte counterflow through the enterocyte membranes under the influence of fluorine].

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Amino Acids↗