Arne Tiselius, 1902-1971.
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Biochemistry↗
Biomedical subjects
R A Kekwick
Publications and source records attributed to R A Kekwick.
Thio reduction of human 2 -macroglobulin. The subunit structure.
1. Human alpha(2)-macroglobulin was prepared from a fraction obtained during the large-scale separation of normal human plasma proteins for clinical use. 2. Sedimentation-equilibrium measurements indicated a molecular weight of 725000. A value of 18.1S was obtained for s(0) (20,w). 3. The dissociation that occurs in the pH range 4.5-2.5 and in the region of neutrality in urea-containing solutions is consistent with a dimeric structure of the molecule. 4. The effects of the thiol reagents mercaptoethanol, mercaptoethylamine and N-acetylcysteine were investigated over a range of experimental conditions. Distinct components having sedimentation coefficients of 15, 12 and 8.5S were identified. 5. Conditions were found under which limited reduction with thiol liberated a subunit with a molecular weight approximately one-quarter of that of the intact molecule. This subunit retains the serological specificity of the whole molecule.
Acetylcysteine↗
Hypogammaglobulinaemia in the United Kingdom. X. Preparation and characterization of concentrates of human normal IgG.
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Agammaglobulinemia↗
Studies on the purification and stability of human antihaemophilic factor (factor 8).
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Acid-Base Equilibrium↗