Biomedical subjects

R A Meduri

Publications and source records attributed to R A Meduri.

4 recordsLinked to original sources

PubMed1998

Tamoxifen retinopathy: does it really exist?

BACKGROUND: Tamoxifen retinopathy is known to be an adverse effect of high-dose tamoxifen treatment. Evidence of ocular toxicity at lower doses is less convincing: the aim of this study was to assess the prevalence of the above-mentioned retinopathy in a population treated with low-dose tamoxifen. METHODS: One hundred and twenty-nine women treated with low-dose tamoxifen (20 mg/day) were examined. Visual acuity measurement, slit-lamp biomicroscopy and fundus examination were performed. Patients were reexamined after 6-12 months. RESULTS: Refractile retinal opacities, similar to those previously described as tamoxifen retinopathy, were observed in four patients (prevalence 3.1%; mean duration of therapy 806 days). None of them revealed corneal opacities, papillary and/or macular edema, or visual impairment. The ophthalmoscopic aspect did not change after a mean follow-up of 215 days, although one of these patients had interrupted tamoxifen intake. Statistical analysis (Student's t-test) did not reveal any difference between patients with and those without refractile retinal opacities as far as age, treatment duration and ERG values were concerned. An early hyperfluorescence, reminescent of cuticular drusen, was demonstrated by fluorescein angiography in all four cases. CONCLUSIONS: The present study would seem to confirm that low-dose tamoxifen may induce retinal toxicity in a low proportion of patients, but we cannot be certain that the refractile retinal opacities observed are really caused by tamoxifen, as differentiation from age-related macular degeneration with cuticular drusen appears nearly impossible.

Adult↗

PubMed1998

Pseudoexfoliation syndrome: a cohort study on intraoperative complications in cataract surgery.

Our aim was to determine the rate of intraoperative complications induced by pseudoexfoliation syndrome (PSX) in cataract surgery. We report our experience regarding 1,052 consecutive patients who underwent phacoemulsification. Exact logistic regression was used to examine the role of PSX in intraoperative complications. Odds ratio for intraoperative complications (vitreous loss, capsular break, zonular break) was estimated to be 5.1 for PSX present as compared to when it is absent. PSX was associated with a statistically significant increase in intraoperative complications during cataract surgery (p<0.0001).

Aged↗

PubMed1995

Brain pathology and strabismus.

If we consider the complex and articulate organization of the oculomotor neural system, ie, infranuclear, nuclear, internuclear, and supranuclear levels, how many neuronal structures are implicated and their widespread localization in the central nervous system, and if we understand the various relationships within the oculomotor system and with other cerebral structures, we may easily realize that cerebral diseases and oculomotor disturbances are tightly and reciprocally connected. Many diseases may be associated with ocular movement impairment, sometimes acting on different sites of oculomotor organization. These alterations may have a clear pathophysiologic meaning and a relevant topographic localizing value, otherwise correlations and mechanisms are simply hypothetical. Last but not least for conceptual relevance are the modifications of neuronal anatomy and physiopathologic mechanisms induced by the strabismus. In the past year many articles have been published that analyze the relationships and the pathogenetic role of cerebral anomalies in the context of strabismus syndromes. Of outstanding interest is the proof of cortical and subcortical neural stations' plasticity, and the evidence of a cerebral anatomophysiologic basis of strabismus and amblyopia. In this context the midbrain, pontine, and brain stem nuclei and neuronal organizations have a peculiar importance. We will try to systematically expose, even if briefly, the main contributions in this area.

Brain↗

PubMedDate not supplied

Effects of oxygen-ozone therapy on age-related degenerative retinal maculopathy.

The effects of oxygen-ozone therapy on 20 patients affected by age-related degenerative maculopathy have been studied. Visual acuity and eye fluorangiography were the parameters used in order to evaluate the efficacy of the therapy. Medical ozone was administered intravenously according to the technique called "ozonized major autohemoinfusion", the total amount of ozone ranging from 1,500 to 2,000 micrograms per session for a 4 months period. The results have indicated that the majority of patients showed an improvement of their ocular condition, suggesting continuation of this type of investigation on a larger group of people.

Aged↗