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Biomedical subjects

R A Millar

Publications and source records attributed to R A Millar.

At least 19 recordsLinked to original sources
PubMed1981

Incidence of concurrent systemic disease in the surgical population of a tertiary care hospital.

A retrospective analysis was made of the case records of 1568 surgical patients admitted in 1975 to a tertiary care hospital in the Province of Newfoundland, to determine and classify the incidence of concurrent systemic disease. Almost 60 percent of patients had symptoms or signs of concurrent disease, the numbers increasing progressively from below 30 per cent at 21-30 years, to 90 per cent at ages 71-80. The predominant abnormalities were cardiovascular (60 per cent), followed by respiratory and metabolic conditions (41 and 40 per cent respectively). Detailed findings are presented, including those relating to the incidence of ischaemic heart disease and hypertension, to the coexistence of several diseases, to smoking and chronic obstructive lung disease, to obesity, to diabetes, and to alcoholism. This review documents the high incidence of concurrent disease in surgical patients and has implications for the training of anaesthetists and the organization of their work.

Adolescent↗
PubMed1976

The effects of althesin and thiopentone on sympathetic and baroreflex activity.

In decerebrate rabbits which were mechanically ventilated, both Althesin and thiopentone depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response by both agents. Effects were similar with Althesin injection in animals which were lightly anaesthetized with pentobarbitone. Depression of the arterial pressure and sympathetic components of the baroreceptor reflex was apparent only with high doses.

Alfaxalone Alfadolone Mixture↗
PubMed1975

Circulatory responses to ketamine: dependence on respiratory pattern and background anaesthesia in the rabbit.

In rabbits which were initially conscious or lightly anaesthetized with pentobarbitone, ketamine respectively increased or did not change arterial pressure, whereas in mechanically ventilated animals there was prolonged depression of both pressure and pregangkioinic sympathetic activity. Although respiratory rate slowed during spontaneous ventilation, blood-gas changes were not responsible for these differences. Following bilateral division of the carotid sinus and aortic nerves, a depressor response to ketamine occurred during spontaneous respiration. When respiratory rate was slowed coincidentally with ketamine injection during mechanical ventilation, the circulatory responses were similar to those during spontaneous respiration; this did not occur after carotid and aortic denervation. These variations in the circulatory effects of ketamine, according to respiratory pattern and background anaesthesia, are discussed.

Anesthesia, General↗