Play development in children with HIV infection: a pilot study.
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Child↗
Biomedical subjects
R A Parks
Publications and source records attributed to R A Parks.
Intrastromal crystalline deposits following hydrogel keratophakia in monkeys.
Intrastromal corneal crystals developed in 11 of 49 monkey eyes with hydrogel intracorneal lenticules followed over a 4 year period. All of the eyes, except one, underwent synthetic keratophakia via a microkeratome incision. The diagnosis of crystal formation was initially made by slit-lamp examination and confirmed with specular microscopy (from 21 to 150 days post-hydrogel keratophakia). The crystals were noted to lie in a plane adjacent to the hydrogel lenticule and specular microscopy revealed polychromatic, hyperrefringent crystals with either a rectangular or linear morphology. Prior to intrastromal crystal formation, these corneas developed early postoperative stromal edema (< 3 weeks). We hypothesize that early stromal edema in combination with the hydrogel intracorneal lenticule induced the production of lipid crystals by stromal keratocytes.
Animals↗
Hydrogel keratophakia: long-term morphology in the monkey model.
After 8.5 years a rhesus monkey with bilateral hydrogel (Permalens) intracorneal implants was evaluated by light microscopy and transmission electron microscopy to determine the long-term effects of a synthetic plastic upon the primate cornea. Light microscopy revealed that the hydrogel lenticules were implanted between 80 and 90% of stromal depth, causing posterior bulging of the stroma into the anterior chamber; this was also seen clinically with slit-lamp biomicroscopy. Some minor pathologic changes were also found elsewhere in the cornea, including epithelial remodelling anterior to the hydrogel implant and a few vacuolated endothelial cells posterior to the edges of the implant. Histologically, no inflammatory reaction was seen in either cornea. This primate demonstrates the long-term biocompatibility of hydrogel intracorneal lenses.
Animals↗
Motor performance changes in children testing positive for HIV over 2 years.
OBJECTIVE: To determine the effect of HIV infection on the motor performance of children and preadolescents, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) was administered to see whether performance scores (raw and standard) would change with duration of the disease. METHOD: Thirty-four children and preadolescents were tested on the BOTMP at initial diagnosis of HIV positive and again at 6-month intervals over a 2-year period for a total of five test sessions. The participants' scores on the Gross, Fine, and Battery Composites, as well as eight individual subtests, were compared with those of children who were developing typically. RESULTS: Gross Composite and Battery Composite percentile scores were consistently 1 to 2 standard deviations below the means for the normal reference populations over the 2-year period. Fine Composite scores were closer than +.5 standard deviation to the mean for the normal reference population. CONCLUSION: Gross motor function was more impaired than fine motor function in this sample of children and preadolescents who were HIV positive, and this pattern was unchanged after 2 years of infection. The BOTMP can be useful both to identify specific areas of motor deficits and to monitor changes in motor function over time after application of interventions.
Adolescent↗