Biomedical subjects

R A Poldrack

Publications and source records attributed to R A Poldrack.

5 recordsLinked to original sources

PubMed1998

The role of left prefrontal cortex in language and memory.

This article reviews attempts to characterize the mental operations mediated by left inferior prefrontal cortex, especially the anterior and inferior portion of the gyrus, with the functional neuroimaging techniques of positron emission tomography and functional magnetic resonance imaging. Activations in this region occur during semantic, relative to nonsemantic, tasks for the generation of words to semantic cues or the classification of words or pictures into semantic categories. This activation appears in the right prefrontal cortex of people known to be atypically right-hemisphere dominant for language. In this region, activations are associated with meaningful encoding that leads to superior explicit memory for stimuli and deactivations with implicit semantic memory (repetition priming) for words and pictures. New findings are reported showing that patients with global amnesia show deactivations in the same region associated with repetition priming, that activation in this region reflects selection of a response from among numerous relative to few alternatives, and that activations in a portion of this region are associated specifically with semantic relative to phonological processing. It is hypothesized that activations in left inferior prefrontal cortex reflect a domain-specific semantic working memory capacity that is invoked more for semantic than nonsemantic analyses regardless of stimulus modality, more for initial than for repeated semantic analysis of a word or picture, more when a response must be selected from among many than few legitimate alternatives, and that yields superior later explicit memory for experiences.

Amnesia↗

PubMed1997

Functional anatomy of long-term memory.

Memory in the brain is organized into multiple memory systems that perform different memory functions and have different neurologic substrates. Declarative memory involves conscious memory for facts and events. The medial temporal lobe and structures in the diencephalon are essential in the establishment of new declarative memories, and these memory traces are finally stored in domain-specific regions of the cerebral cortex. The frontal lobe and basal ganglia are important in some forms of declarative memory that require reasoning about the contents of memory. Nondeclarative forms of memory (including skill learning, repetition priming, and classical conditioning) do not involve conscious recollection and are measured through changes in the way in which tasks are performed. These forms of memory rely upon the cerebral cortex, basal ganglia, and cerebellum.

Amygdala↗

PubMed1997

Fluency and response speed in recognition judgments.

Previous research has suggested that perceptual fluency can contribute to recognition judgments. In this study, we examined whether fluency in recognition is based upon the speed of preceding operations, as suggested by studies of perceptual fluency. Subjects studied items in both lexical decision and naming tasks, and were then tested on two blocks of lexical decision trials with probe recognition trials. Jacoby's process dissociation procedure was used, and results from this procedure suggested that recognition judgments in the task were based largely upon familiarity. However, the estimated discriminability available from response time distributions was significantly less than the observed recognition discriminability. Simulated memory operating characteristics confirmed this under determination of recognition by response times. The results demonstrate, contrary to previous suggestions, that fluency in recognition is not based upon speed.

Adult↗

PubMedDate not supplied

Memory for items and memory for relations in the procedural/declarative memory framework.

A major area of research in memory and amnesia concerns the item specificity of implicit memory. In this paper we address several issues about the nature of implicit memory phenomena and about what constitutes an "item", using the procedural/declarative memory theory to guide us. We consider the nature of memory for items and of memory for relations among items, within the context of the procedural/declarative framework, providing us with the foundation necessary to analyse the basis for item-specific implicit memory phenomena. We review recent work from our laboratories demonstrating the fundamentally relational and flexible nature of declarative memory representation, in both humans and animals, and the essential role of the hippocampal system in relational memory processing. We show, further, that the memory representations supporting implicit memory phenomena are inflexible and nonrelational, and are tied to specific processing modules. Finally, we introduce empirical approaches that blur the distinction between skill learning and repetition priming, and show computational modelling results that demonstrate how these two implicit memory phenomena can be mediated by a single incremental learning mechanism, in accord with the claims of the procedural-declarative theory. Taken together, these various analyses of memory for items and memory for relations help to illuminate the nature of the functional deficit in amnesia and the memory systems of the brain.

Amnesia↗

PubMedDate not supplied

The neural basis of visual skill learning: an fMRI study of mirror reading.

The learning of perceptual skills is thought to rely upon multiple regions in the cerebral cortex, but imaging studies have not yet provided evidence about the changes in neural activity that accompany visual skill learning. Functional magnetic resonance imaging (fMRI) was used to examine changes in activation of posterior brain regions associated with the acquisition of mirror-reading skill for novel and practiced stimuli. Multiple regions in the occipital lobe, inferior temporal cortex, superior parietal cortex and cerebellum were involved in the reading of mirror-reversed compared to normally oriented text. For novel stimuli, skilled mirror-reading was associated with decreased activation in the right superior parietal cortex and posterior occipital regions and increased activation in the left inferior temporal lobe. These results suggest that learning to read mirror-reversed text involves a progression from visuospatial transformation to direct recognition of transformed letters. Reading practiced, relative to unpracticed, stimuli was associated with decreased activation in occipital visual cortices, inferior temporal cortex and superior parietal cortex and increased activation in occipito-parietal and lateral temporal regions. By examining skill learning and item-specific repetition priming in the same task, this study demonstrates that both of these forms of learning exhibit shifts in the set of neural structures that contribute to performance.

Brain↗