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Biomedical subjects

R A Sargent

Publications and source records attributed to R A Sargent.

8 recordsLinked to original sources
PubMed1999

Immunohistochemical detection of canine distemper virus in haired skin, nasal mucosa, and footpad epithelium: a method for antemortem diagnosis of infection.

A reliable antemortem diagnostic method is needed for determining infection with canine distemper virus (CDV). The utility of immunohistochemical detection of CDV antigen was examined was examined for samples of nasal and footpad epithelium and haired skin in dogs with and without detectable CDV antigen in the lung and/or brain. Tissues from 57 dogs at risk of CDV infection were tested. Viral antigen was found in the lung and/or brain of 28 dogs. Among these dogs, viral antigen was demonstrated in the epithelial cells of the nasal mucosa in 24 of 27 dogs, in the footpad epithelium in 24 of 26 dogs, and in the haired skin of the dorsal neck in 26 of 27 dogs. Among the 29 dogs without CDV antigen in either the lung or brain, 1 dog had positive staining for viral antigen in the skin and nasal mucosa. Biopsies of haired skin of the dorsal neck, which is relatively simple to sample, can be used for immunohistochemical testing for acute and subacute infection with CDV.

Animals↗
PubMed1990

Syndromes and systemic diseases with eye findings.

Many systemic and congenital diseases include ocular manifestations. Some are primarily ocular in importance, while others have a multiple-organ spectrum. The specific entities are the more frequently encountered diseases in a hospital or pediatric office practice.

Abnormalities, Multiple↗
PubMed1984

Flammability of silicone rubber: an unrecognized hazard.

A patient sustained a burn when silicone rubber tubing was ignited by a pencil cautery unit. Unlike polyethylene, silicone rubber does not melt prior to reaching its ignition temperature. The application of heat near or to silicone rubber is to be avoided.

Burns↗
PubMed1979

Dissociated hypertropia: surgical treatment.

Dissociated hypertropia can be corrected surgically by recession of the superior rectus muscle or resection of the inferior rectus muscle. The usual "maximum" amount of surgery of 4-5 mm is the minimum amount of surgery necessary for correction of this cosmetically disfiguring strabismus. Complications relate to narrowing of the palpebral fissure width and restrictive hypotropia" both following marked inferior rectus muscle resections.

Adolescent↗
PubMedDate not supplied

Anterior uveitis associated with Kawasaki syndrome.

Forty-one children with a clinical diagnosis of Kawasaki syndrome had a pediatric ophthalmologic examination performed at a mean time of 8.6 days after onset of fever. Twenty-seven of 41 patients (66%) had evidence of anterior uveitis by slit lamp examination. Bilateral involvement was noted in 25 of 27 patients (97%). Punctate keratitis was evident in 5 of 41 patients (12%). Three of these five had coexisting uveitis. The incidence of anterior uveitis in patients examined during the first week of their illness was 83% (20 of 24 patients), compared to an incidence of 41% (7 of 17) in patients first examined greater than 1 week after onset of disease (P = 0.004). There was no difference in the uveitis, vs. the non-uveitis groups with respect to age, sex, race or subsequent aneurysm formation as a complication of their Kawasaki syndrome. The mean erythrocyte sedimentation rate was not different in the two groups. Anterior uveitis is a common finding early in the course of Kawasaki syndrome. Slit lamp examination may be a helpful clinical tool in identifying patients with Kawasaki syndrome, and uveitis should be considered for inclusion in the Centers for Disease Control case definition of Kawasaki syndrome.

Child↗
PubMedDate not supplied

One versus two simultaneous goniotomies as the initial surgical procedure for primary infantile glaucoma.

To evaluate whether a more extensive incision of the tissue adjacent to the anterior trabecular meshwork resulted in more effective control of intraocular pressure (IOP), seven infants with bilateral congenital glaucoma underwent a single goniotomy in one eye and two simultaneous goniotomies at separate sites in the second. Sodium hyaluronate (Healon) was used in all eyes undergoing two simultaneous goniotomies and in three to seven eyes undergoing a single goniotomy. Success was not significantly different, at 1 month or 1 year postoperatively, for eyes which underwent two simultaneous and separate goniotomies. Successful control of IOP was, however, related to the preoperative IOP. Eyes for which the initial procedure was unsuccessful had a significantly higher IOP. The incidence of postoperative hyphemas was less in eyes in which the Healon was used intraoperatively, but the use of Healon did not favorably or adversely affect intraocular pressure control.

Eye Diseases↗