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Biomedical subjects

R A Schuchard

Publications and source records attributed to R A Schuchard.

11 recordsLinked to original sources

Characteristics of AMD patients with low vision receiving visual rehabilitation.

The purpose of this retrospective study done on 255 AMD patients evaluated at a low vision rehabilitation service was: 1) to describe the visual function characteristics (VFCs) of AMD patients presenting to visual rehabilitation, 2) to document changes in these VFCs between initial and follow-up rehabilitation visits, and 3) to investigate the relationship of the VFCs found at rehabilitation intake to the length of time between initial diagnosis and initial rehabilitation visit. Standard clinical testing (visual acuity and contrast sensitivity) as well as Scanning Laser Ophthalmoscope (SLO) visual function testing were performed to determine visual function including: 1) macular perimetry for scotoma boundary mapping and 2) PRL (preferred retinal locus) location and abilities in fixation, saccadic, and pursuit eye movements. The difference between the first and second visit VFCs were compared to the length of time between visits for 44 of the 255 patients returning for a second visit 0.5 to 4.5 years later. Finally, the initial date of AMD diagnosis was found for 51 of the 255 patients to analyze VFCs as a function of the time duration between diagnosis and the intake to the rehabilitation. Most VFCs had a wide range of results at initial intake to rehabilitation, while all patients had significant visual impairment by 24 months after initial diagnosis. The majority of low vision patients with AMD have bilateral central scotomas with the corresponding visual function and ADL problems that can often be overcome with visual rehabilitation.

Aged↗

Relative locations of macular scotomas near the PRL: effect on low vision reading.

Patients referred for low vision rehabilitation had Minnesota Reading Acuity (MNRead), visual acuity (VA), and scanning laser ophthalmoscope (SLO) macular function testing performed in their initial evaluation to determine whether dense macular scotomas near the preferred retinal locus (PRL) have a significant effect on the characteristics of reading based on rate. The 99 subjects had macular scotoma characteristics relative to the fovea/PRL of: 22% only to the right; 15% only to the left; 26% both the right and left; 19% above or below; 17% had no dense scotomas. Reading performance (maximum reading speed, critical print size, and reading acuity) was significantly different between the non-scotoma group and all of the scotoma groups. There was no statistically significant difference in the characteristics of reading based on rate between the four scotoma groups: within each there was a wide variation in the characteristics of reading based on rate not fully explained by either VA or scotoma location. The position of the scotoma relative to the PRL was not a statistically significant factor in determining reading rate as found in studies on normally sighted people with artificial scotomas. Other factors (e.g., maybe PRL ability in fixation and saccadic eye movements and/or cognitive ability) are significantly involved in determining reading rate characteristics in people with macular scotomas.

Humans↗

Preferred retinal loci relationship to macular scotomas in a low-vision population.

PURPOSE: The authors identified patterns in preferred retinal locus (PRL) ability and location relative to macular scotomas in a low-vision patient population. METHODS: Scanning laser ophthalmoscope macular perimetry and PRL testing were performed on 825 patients with low vision. The PRL location was determined, and a PRL scoring system was devised and used to measure the pursuit ability, fixation stability, and saccadic ability of the PRL. The characteristics of dense scotomas within 2.5 degrees of the PRL were noted. RESULTS: Eighty-four percent (1130 of 1339 eyes) of the eyes had an established PRL. Preferred retinal loci varied across the full range of ability scores and varied in size for fixation stability from 1.0 degrees to 9.0 degrees in diameter. There was a central dense scotoma in 82.5% of the eyes, whereas 8.4% had a paracentral dense scotoma. In 14.8% of the eyes, the PRL had no dense scotomas on any of its borders; one, two, three, or four (a ring) borders had a dense scotoma in 39.7%, 19.0%, 9.0%, and 17.4% of eyes, respectively. When the PRL had only one scotomatous border, the resulting field defect was located superior in 39.0%, right in 33.7%, left in 19.9%, and inferior in 7.5% of eyes. CONCLUSIONS: The majority of patients with low vision, as many as four of five patients, have dense scotomas encumbering the PRL for visual tasks. Approximately one of six patients with low vision have the PRL completely surrounded by dense scotomas. The visual system shows a strong tendency not to place a PRL anatomically above a scotoma (field defect below fixation) and a weaker tendency not to place the PRL anatomically to the right of a scotoma (field defect to the left of fixation). Macular perimetry and PRL evaluations can provide considerable information on the functional status of the macula, which may be useful to rehabilitation professionals.

Humans↗

Using two preferred retinal loci for different lighting conditions in patients with central scotomas.

PURPOSE: Using a scanning laser ophthalmoscope, it was found that some patients with relative central scotomas reliably used two different preferred retinal loci (PRLs) at different stimulus illuminances. This article describes adaptations in a patient's PRL for fixation when dimming the stimulus increased the relative scotoma size. METHODS: Twenty-eight patients with macular diseases had their dense and relative macular scotoma borders mapped with the scanning laser ophthalmoscope. The high-illuminance PRL (PRLhi) and low-illuminance PRL (PRLlo) were operationally defined as the PRLs that patients used to fixate a high or low illuminance stimulus, respectively. The PRLs' abilities to do visual tasks and their characteristics at the corresponding illuminances were assessed. RESULTS: The PRL consistently shifted between the PRLhi and the PRLlo as the stimulus illuminance was changed. Brightness permitting, the visual system prefers to use the PRLhi with generally better performance in visual function such as fixation stability. There were no significant differences between the PRLhi and the PRLlo in pursuit and saccadic abilities, when assessed by subjective ratings. The illuminances that induced shifting ranged from 106 to 3437 trolands. The PRLhi was always located within an area of relative scotoma, usually at the fovea or just outside a dense scotoma. The PRLlo was located in relatively healthy retinal area, and usually below or to the left of the PRLhi in the visual field. CONCLUSIONS: In the visual system, two well-defined PRLs can develop when visual function is adapting to maculopathy, with the use of each depending on the brightness of objects used in visual tasks. Rehabilitation and treatment strategies should consider the existence of multiple PRLs.

Adaptation, Ocular↗

Scanning laser ophthalmoscope macular perimetry in the evaluation of submacular surgery.

PURPOSE: Submacular surgery for choroidal neovascularization (CNV) is under investigation in the treatment of age-related macular degeneration (AMD) and the presumed ocular histoplasmosis syndrome. Four case studies are presented to demonstrate scanning laser ophthalmoscope (SLO) testing in the pre- and postsurgical evaluation of visual function in patients with subfoveal CNV secondary to AMD, presumed ocular histoplasmosis syndrome, and submacular hemorrhage secondary to AMD. METHODS: Patients underwent a visual assessment pre- and 6 months postoperatively, consisting of low vision visual acuity measurement, SLO macular perimetry of dense and relative scotomas, and analysis of the preferred retinal locus for fixation (PRL) location and ability. RESULTS: Visual acuity, dense and relative scotoma size and location, and PRL location were compared; and relationships between anatomic and functional changes were observed. Decreases in scotoma size and improvement in PRL location and ability usually corresponded with improved visual acuity. Preoperative scotoma and PRL location guided retinotomy site selection. CONCLUSION: Scanning laser ophthalmoscope macular perimetry and PRL testing may be useful adjuncts in the visual assessment of submacular surgery and may advance under-standing of the effects of submacular surgery on visual function. In addition, this testing may be used to plan location of surgical interventions for macular diseases.

Adult↗

Adaptation to macular scotomas in persons with low vision.

Persons with scotomas in their central 20 degrees of vision often do not notice these blind spots within their visual field and have visual performance difficulties far exceeding what would be expected from standard vision tests. Before persons with macular scotomas can be assisted to optimally use their remaining vision for a better quality of life, more must be known about how the visual system adapts to a macular scotoma. Important issues include spatial and temporal characteristics of perceptual completion and metamorphopsia, development of preferred retinal loci for fixation and visual search, and dynamics of the preferred retinal locus development in terms of the changes in the eye movement system. With a full understanding of the visual system's adaptation to macular scotomas, new low vision devices and training techniques can be proposed to promote independence in activities of daily living for the person with low vision.

Activities of Daily Living↗

Landmark-driven fundus perimetry using the scanning laser ophthalmoscope.

PURPOSE: To present a new method of performing scanning laser ophthalmoscope perimetry that compensates for eye movements so that the correct retinal location is tested even if fixation changes. This allows for accurate testing of patients with central scotomas and for repeating testing longitudinally at the same retinal locations even if central fixation is lost. METHODS: The operator views the retina and selects a retinal landmark, such as a vessel bifurcation, that can be identified easily. A testing strategy is preselected, and the computer saves the landmark and stimulus coordinates. To present each stimulus, the operator positions a cursor over the retinal landmark, and the computer adjusts the site of presentation of the stimulus for any change in landmark position caused by an eye movement. At the conclusion of the testing, the results are displayed in the proper retinal location on a fundus image. RESULTS: Sixty-seven eyes with macular disease were tested with the landmark-driven method, using the same preplanned strategy for each eye for both a bright and a dim stimulus. There was a low rate of inconsistent points (seen with dim but not bright stimuli), and virtually all of these bordered a dense scotoma. Those eyes with more inconsistent points had a significantly greater percentage of dense scotoma points and significantly lower visual acuity. The technique significantly corrected error in retinal localization resulting from large eye movement. There is no significant rotation or magnification change during the procedure, so specifying the change in location of one landmark is sufficient to describe movement of the retina. The technique is rapid and easy to administer to elderly patients and to children. CONCLUSIONS: This technique allows for accurate and repeatable measures of retinal sensitivity in specific locations. It is useful in following change over time. It can be developed further to allow for fully automated, retinally correct testing.

Adolescent↗

Validity and interpretation of Amsler grid reports.

OBJECTIVE: To compare the reports of scotomas and metamorphosia in standard and threshold Amsler grid testing with the location and extent of scotomas in the macular region as determined by standard and threshold fundus perimetry. DESIGN: Fundus perimetry determined the existence, size, and retinal location of macular scotomas. Amsler grid testing was performed with the scanning laser ophthalmoscope and the TA-300 system (Stereo Optical, Chicago, Ill). All testing was done at both standard and threshold light conditions. PATIENTS: Fifty-five patients with vision loss in the macular region and 10 normally sighted subjects. RESULTS: Nearly half of the standard and threshold scotomas were not detected by Amsler grid testing. For scotomas of 6 degrees or less in diameter, 77% of standard and 87% of threshold scotomas were not detected by Amsler grid testing. Of the eyes with central scotomas involving the fovea, 66% used an eccentric preferred retinal locus for fixating the center of the grid. Finally, more than half of the distortion reported in Amsler grids was at the retinal area that corresponded to the scotoma area, not a nonscotoma retinal area. CONCLUSION: Amsler grid reports have poor validity and cannot be accurately interpreted for use in the clinical diagnosis of retinal defects.

Adolescent↗

SLO radiant power and brightness.

Available output in the Scanning Laser Ophthalmoscope (SLO) may be expressed as radiant power at the beam pivot (SLO exit pupil), in units of microwatts (microW). This power corresponds to dimensions of brightness (like luminance and retinal illuminance) and to a range of related measures (like cd/m2, lm/m2, and the troland value) in both free and Maxwellian views. We demonstrate that the conversion factor power/troland=1.26*10(-3) microW and 3.15*10(-4) microW for SLO nominal visual angles 40 degrees and 20 degrees, respectively. The factor permits measured SLO power to be expressed in units of brightness and (inversely) brightnesses of everyday objects to be expressed in units of SLO power. Examples of both conversions are given. Reference to the literature demonstrates the importance of expressing SLO power in brightness terms common to everyday activities and to visual function-testing instruments besides the SLO.

Calibration↗

SLO power calibration.

We present a method for calibrating the Scanning Laser Ophthalmoscope (SLO) that predicts radiant power at any of 256 grayscale values (gsv) and 12 polarized filter (polarizer) levels. Predicted power values, p(gsv), were determined by substitution into polynomials linearly transformed to old or new power at p(0) and p(255). This was compared with observed power values at 125 levels of attenuation/session. Prediction accuracy was the proportion of nonsignificant pairwise comparisons (t-test, p=0.0001). We found that power transformation between polarizers and within sessions has both linear and nonlinear characteristics. Within polarizer and between sessions, however, power transformation has linear characteristics. A 5th-degree polynomial was individually fit, at each polarizer, to session 1 power distributions of 9 gsv steps (0, 31, 63, 95, 127, 159, 191, 223, 255). When adjusted to p(255) and p(0) in new sessions, we obtained p(gsv) that predicted power at 25 gsv * 5 polarizers for 18 days with an accuracy of about 0.84. When only adjusted to p(255), predictive accuracy was 0.81.

Calibration↗