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Biomedical subjects

R A Secter

Publications and source records attributed to R A Secter.

3 recordsLinked to original sources

Amrinone: a weaning agent in catecholamine dependence.

Amrinone, a new inotropic agent, has been used successfully in refractory chronic congestive heart failure. Intravenous and subsequently oral amrinone administered in a setting of acute myocardial infarction and dopamine dependence allowed the catecholamine to be successfully weaned after volume loading, digitalization and vasoconstrictors failed to terminate dopamine dependence. There was the expected fall in filling pressure and increase in cardiac index and ejection fraction. Intravenous amrinone may be tried in refractory catecholamine dependence after conventional weaning methods have failed.

Aged↗

Use of colestipol in a patient with digoxin intoxication.

The steroid-binding drug colestipol was administered to a patient with digoxin intoxication and the serial digoxin levels were measured. The actual half-life of elimination of digoxin was 55 hours, whereas the predicted half-life calculated from standard pharmacokinetic equations was at least 85 hours. Colestipol presumably interrupts the enterohepatic recycling of digoxin and enhances its fecal excretion. This is the first documented report of the successful use of colestipol for digoxin intoxication.

Colestipol↗