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Biomedical subjects

R A Stuhlman

Publications and source records attributed to R A Stuhlman.

17 recordsLinked to original sources

Histopathology in hosts parasitized by Sarcoptes scabiei.

Histopathologic evaluation of nondermal tissue in rabbits infested with Sarcoptes scabiei var. canis was investigated. Severe infestation resulted in deviant serological and serum biochemical values. Histological study revealed structural changes in the tissues of specific organs. The most prominent histological finding was amyloidosis in the liver, glomerulus of the kidney, red pulp of the spleen, intestines, and tongue. Hosts treated for infestation exhibited no abnormal organ histology.

Adrenal Glands↗

Diabetes mellitus in the 13-lined ground squirrel (Citellus tridecemlineatus).

Spontaneous diabetes mellitus was diagnosed in six of 126, 13-lined ground squirrels, Citellus tridecemlineatus. Serum glucose values were significantly higher in the diabetic ground squirrels than in the non-diabetic ground squirrels, while serum insulin values of fasted diabetic squirrels were significantly lower than fasted nondiabetic ground squirrels. In addition, the classic diabetic signs of poly-dipsia, polyuria, glycosuria, ketonuria, polyphasia, and weight loss were present. The proportion of islet tissue to total pancreatic area in diabetic ground squirrels was less than 25% of that in the nondiabetic ground squirrels. Both the number and size of the islets of Langerhans in diabetic ground squirrels were less than those in nondiabetic ground squirrels.

Animals↗

Relationship between pancreatic lesions and serum glucose values in Mystromys albicaudatus.

Serum glucose levels and pancreatic islet cell changes were studied in combination in 127 Mystromys albicaudatus in an effort to develop better criteria for defining diabetes mellitus in thiss rodent. The study supports a previous report in which 170 mg/100 ml was selected as indicative of hyperglycemia based on statistical analysis of serum glucose distributions. The presence of exceptions to predicted correlations between islet cell changes and serum glucose levels was identified for further study.

Age Factors↗

Glomerular lesions of diabetes mellitus in Mystromys albicaudatus.

The kidneys of 175 nondiabetic and diabetic Mystromys albicaudatus were evaluated histologically by light microscopy. The degree of capillary basement membrane thickening and the predominant glomerular histologic pattern were recorded. Statistical analyses indicated that glomerulosclerosis is associated with diabetes in this species. In addition, a granular capillary basement membrane lesion occurred more frequently in diabetic than in nondiabetic animals.

Animals↗