Biomedical subjects

R A Vignale

Publications and source records attributed to R A Vignale.

At least 19 recordsLinked to original sources

PubMed1997

Effective management of marked lymphedema of the leg.

BACKGROUND: Several conservative and surgical treatment methods have been demonstrated to be useful in the management of lymphedema. METHODS: In a patient with an enormous lymphedema of the leg, we first used complex decongestive physiotherapy as proposed by Földi et al. in 1989, and then followed it with surgery. RESULTS: Satisfactory results were obtained in a short period of time and were maintained during the 2-year follow-up. CONCLUSIONS: We recommend a combined medical, surgical, and physiotherapeutic approach in patients with marked lymphedema.

Combined Modality Therapy↗

PubMed1990

[Disseminated annular granuloma in a patient with scabies].

A male patient of 52 years old is studied with an scabiei by Sarcoptes scabiei v. hominis. After a month the patient developed a clinic and histopathologic generalized granuloma annulare. With the specific local treatment of his scabiei, the disease was cured in 7 days. After this treatment, the generalized granuloma annulare disappeared within 2 months. Due to the sequence of both diseases and the way in which they disappeared after local therapy, we suggest that the antigens of the scabies are the ones responsible for the granulomatous lesions. We concluded this since once the antigens have disappeared, the immunologic mechanisms depending on the interactions of lymphocyte T-macrophage which form the granuloma are interrupted. Since the patient is homosexual, we studied the HIV antibodies which were negatives in several opportunities. Nevertheless, an immune disbalance which could be the coadjuvant factor was founded. With this case we show that specific exogens may cause a generalized granuloma annulare.

Granuloma↗

PubMed1990

[Bazex's para-neoplastic acrokeratosis. A clinical case with hyperpigmentation].

We studied a white skin type 3 male patient aged 68 years old with a paraneoplastic acrokeratosis of Bazex, suffering from an oesophagus neoplasm. Cutaneous manifestations preceded in months the cancer. Dermatosis affected fingers of hands and feet, soles, nose and helix. Black melanic hyperpigmentation was the first cutaneous sign and were followed by an hyperkeratosis, becoming the most clinical characteristic of the syndrome. The sequence of these signs induces us to suggest that hormonal factors elaborated by the tumoral cells are the ones responsible for the pigmentary changes since they appeared before the hyperkeratosis.

Acrodermatitis↗

PubMed1986

[Halo nevus. In situ study using monoclonal antibodies].

Using immunocytochemical methods the inflammatory-cell infiltrate from 7 halo nevi were studied. Monoclonal antibodies, Cris-1, OKT3, OKT4, OKT8, A47, Edu-1, OKT6 and anti-immunoglobulins were employed. The results shows that the predominant cells in the inflammatory-cell infiltrate were T cytotoxic/suppressor activated lymphocytes. An increased number of epidermal Langerhans cells and IgM deposits in epidermal-dermal junction was also observed. Thus, the results are able to postulate that self-involution of halo nevi was mediated by cytotoxic cellular immune reactions.

Antibodies, Monoclonal↗

PubMed1985

[Visual and auditory evoked potentials in latent syphilis].

The evoked potentials visual and auditory are studied in 43 patients with latent syphilis without previous mucocutaneous lesions. Twenty nine of them had not received treatment, and 14 due to their positive serology were treated with benzathine penicillin. At the visual potential evoked there were no abnormalities but in 20 cases evoked auditive potential were abnormal. This findings suppose the existence of subclinical neurological indicates the existence of lesions in almost 50% of the cases of this period of syphilis. All these patients had positive circulate immune complexes and normal cerebro-spinal fluid. The neurological alteration consists in a lesion of the cerebral trunk. According to these results the auditory potential evoked test is very important. The authors doubt on the efficacity of the benzathine penicillin in this period of syphilis.

Adult↗

PubMed1985

[Classification of the developmental periods of syphilis].

With the acquisition of specialized laboratory techniques, as the determination of serum immune complexes and the auditory evoked potentials, which bring new knowledge, the study of syphilis must be reviewed, in particular the classification of the evolution periods. The authors consider latent syphilis and neuro-syphilis. Based on these facts the new ways of treatment as well as the evolution control must be revised. These test should always be performed in order to determine exactly the syphilis period of the patient.

Antigen-Antibody Complex↗

PubMed1984

[Congenital cutis laxa].

A case of connatal flabby skin or generalized dermatochalasia without genetical familial background is presented. The cutaneous clinic is striking to which pulmonary emphysema with overcharge of the right heart is added. By optical and electronic microscopy the characters of elastic fibers are studied which show diminished with orceing with a normal microfibrilar component lacking the amorphous element or elastine with the electronic microscope. The formation of the dense normal element also appears compromized .

Cardiomegaly↗

PubMed1984

[Keratosis palmaris and visceral cancer].

The authors describe the clinical and histological characteristics of palmar keratose associated to visceral cancer. Their clinical forms are small and numerous keratotic rings, large papulae, 4 to 8 mm., scarce two or three lesions and multiple punctiform depressions. The histology shows a compact orthokeratotic hiperkeratosis accompanied in a variable way to an epidermic depression. In a strict sense it is not a paraneoplase, it is a clinic visceral cancer marker. It is suggested to name it oncogenic lenticular acrokeratose.

Abdominal Neoplasms↗

PubMed1984

[Cytotoxicity in psoriasis].

The authors study three cytotoxicity system in psoriasis: direct cytotoxicity (DCC), antibodies mediated cytotoxicity (ADCC) and activated lymphocytes mediated cytotoxicity (PCC). The results of DCC and PCC are in the normal values, while ADCC are a somewhat increased, showing a hyperactivity of this system, which could explain some physiopathological phenomena of this disease. We consider this finding as secondary to an alteration of the immune system by dysbalance of B-T lymphocytes.

Adolescent↗

PubMed1984

[Epidemiologic aspects of cancer of the skin in Uruguay].

The authors describe the demographic characteristics of Uruguay. The annual rate of mortality by skin cancer, except melanoma, is of 0.6 100,000 inhabitants. It has been calculated an incidence of 725 new cases a year. The Oncology Institute casuistic of 361 cases recorded from 1973 to 1978 show a promedial age of 65 years, all of white race, with neat predominance of male sex for epitheliomes of exposed areas and identical distribution for those of truck and limbs. Most of the patients with head and neck tumours were from rural areas. All this data confirm that the sunlight is the principal induction factor of non melanoma skin cancer in Uruguay.

Female↗

PubMed1984

[Dysplasic nevus syndrome].

We present a case of malignant melanoma arising in a pacient we postulate as a "nevus dysplasia" syndrome carrier. A revision is realized about the subject emphasithing the importance in the recognition and correct valuation of the entity, that is essential for the malignant melanoma prophylaxis.

Adult↗

PubMed1984

[Basal cell epitheliomas of the extremities. Presentation of 16 cases].

The authors study 16 cases of basal cell epithelioma of the limbs, 5 from the upper ones and 11 of the lower ones. They expose their particular clinical characteristics which have not been shown at bibliography there are studied. Are atypical forms all the distal or acral sectors: erythemato-squamous, exofitic and nodular without melanic pigmentation, pearl papulae or telangiectasis, which makes difficult a precise diagnosis. Proximal limb lesions shown the typical semiology of basal cell epitheliomas of head and neck. The exofitic forms have fasted evolution, while the others grow slowly. Histologically it has been demonstrated a clear predominance of solid undifferentiated forms: 12/16. The statistical studies suggest an increase of basal cell epithelioma of the limbs during the lats quinquenium, probably related to a more intensive exposition to sunlight.

Aged↗

PubMed1984

[Modulation of the lymphocyte membrane with anti-HLA ABC in psoriasis].

Antibodies against lymphocyte surface antigens are able to rearrange the topographic of the cell membrana. This is the first event of immune cell functions for motility and cell adherence. Take in account: the high incidence of some HLA antigens in psoriasis and that the HLA system is involved in the genetic control of immune responses, we studied the reaction of anti HLA antibodies against lymphocytes from 16 patients with active psoriasis and from six healty controls. For this: lymphocytes T or B are sensitized with optimal amounts of anti HLA ABC antibodies. They are washed and resuspended in a nutrient medium and incubated at 37 degrees C. At 0, 3, 4, 5 and 6 hours samples are taken and observed for microlymphocytoxicity after addition of complement. Controls for viability and for antigenic sites are made. The addition of complement shows a decrease in the cytotoxic reaction. This is due to the loss from the cell surface of the antigen-antibodies complexes. The observed phenomenon is paralleled to the rearrangement of membrane proteins and is developed in a similar period to the normal antigen turnover time. Our results demonstrate a significative decrease in the turnover for HLA ABC molecules at the cell surface of T lymphocytes from psoriasic patients, that we assimilate to an altered rearrangement of HLA ABC molecules. No significative differences was observed for the turnover of HLA ABC molecules at cell surface of B lymphocytes. The altered T lymphocyte membrane demonstrate an immunobiologic defect and it may the explanation for the impairment for the T cell function in psoriasis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1984

[Change in the turnover of HLA ABC molecules in circulating T lymphocytes in mycosis fungoides].

The turnover of HLA ABC molecules at T and B lymphocyte surface was analyzed in five cases with mycosis fungoides and six healthy controls. The patients had only skin lesions and are staged from T1 to T3 and No, Bo and Mo. The turnover was analyzed by mean of the decrease of the lysis by complement on sensitisized cells with anti HLA ABC antibodies that were incubated for progressive times at 37 degrees C. The results show a largest turnover for the HLA ABC molecules all T cells surface from mycosis fungoides that was significant (PWilcoxon less than 0.01). The turnover of B cells surface was not different from mycosis fungoide and healthy controls. The observed phenomenon was not specific for mycosis fungoide or T cells because previously has been shown in others lympho-proliferative and autoimmune diseases. The authors suggest that the analyzed T lymphocyte, morphologically normal is functionally altered and the behavious could be a metabolic phenotypic marker for the T cell before his coming at skin lesions.

Adult↗

PubMed1984

[Increase of circulating HLA DR+ T lymphocytes in psoriasis].

HLA DR molecules on the surface of T lymphocytes evidences the immune cell activation. In the course of disease with immunopathogenic mechanisms and after immunostimulation the level of peripheral T HLA DR+ lymphocytes increases. In psoriasis, it was previously demonstrated the existence of T HLA DR+ lymphocytes in the skin lesions. This phenomenon suggests an in situ activation of T cells. In this paper we show an increase of circulating T HLA DR+ lymphocytes in 12 patients with active psoriasis (5.81% +/- 3.17) compared to healthy controls (2.02% +/- 0.47). The difference was significative (P less than 0.01). The authors suggest the systemic activation of T cells in psoriasis that could be controlled by the HLA system.

Adult↗

PubMed1983

[Diagnostic value of keratosis palmaris as indicative sign of visceral cancer].

Palmar keratosis is studied in patients with visceral cancer. It is related to sex and localization. Its higher frequency can be observed in these patients than in controls. Their incidence is larger in the male and in patients with cancer localized in oesophagus, lungs and prostate. In woman the incidence is less than in male and in cancers localized anywhere but breast and uterus. This cutaneous lesion is a very important phenotypical sign in oncology and can be considered as paraneoplasic cutaneous marker.

Adult↗

PubMed1983

[Epidermic and lymphocytary chalone receptors in psoriasis].

By Hondius-Boldingh. Laurence and Bullough, Laurence method, the activity of the epidermal chalone receptors was studied in 36 psoriasis and 36 healthy controls. The lymphocyte chalone receptors was also studied in 26 patients, by Garcia Giralt et al. and Lasalvia et al. method. The results showed that the epidermal chalone receptors are significantly decreased in the involved skin, and in a lesser degree in the uninvolved one of the patients with psoriasis. The lymphocyte chalone receptors were normal. This decreasing in the function of the epidermal chalone system by means of different "antireceptor factors", interrupt the physiological cell control of the epidermis. The absence of the chalone specific function, produces an intracelular disbalance which provokes, in particular, the high number of mitosis and the lack of terminal differentiation. These elements admit that in psoriasis there is an abnormal epidermopoyesis. Over a genetic disorder, multiple factors leading to a deffect of the cell membrane. These factors, acquired, local or systemic interfering with the receptors of membrane, would alter the cellular regulation induced my the chalones.

Adolescent↗

PubMed1983

[Epidermic chalone receptors in psoriasis treated with retinoid:Ro 10-9359].

The epidermic chalone receptor of skin with lesion and without lesion are studied on 20 patients with active psoriasis. The testlest were performed before and two month after oral treatment with RO 10-9359. Roche. The results show significant variation with an increased a the number of receptors after treatment. As these receptors are in the cell membrane, the authors consider that RO 10-9359 action in on the membrane and its surrounding, making in possible to the epithelial cell to begin its autoregulation, autocontrol and differentiation when the specific activity of the chalones become normal.

Adolescent↗