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Biomedical subjects

R A Vignale

Publications and source records attributed to R A Vignale.

46 records · Page 3Linked to original sources
PubMed1981

[In vitro blastogenic response of lymphocytes in pityriasis capitis and dermatitis seborrheica (using PHA-mitogen, Pityrosporum ovale and bacteria)].

63 patients with Pityriasis capitis (PC) "dandruff" and Seborrheic dermatitis (SD) as well as normal controls were studied. Antigenicity was checked "in vitro" by the lymphocytic transformation test. A significant transformation in the PC to P. ovale was observed while in SD it was to Stanphyloccocus and P. ovale. In view of results the authors suggest that there is a similar immunoalergic response in the host to those antigens. The clinic will differ according to the antigens. This is significant for a new local treatment and general.

Antigens, Bacterial↗
PubMed1981

[Physiopathological mechanisms in acne vulgaris].

The physiopathological mechanisms of the different degrees of the Acne Vulgaris are reviewed. The observations show the important antigenic activity of the "Propionibacterium acnes" and the cellular immunity in the inflammation. An immunologic concept could explain this process.

Acne Vulgaris↗
PubMed1980

Antireticulin antibodies in psoriasis.

Antireticulin antibodies were studied in the sera of 32 patients affected by various clinical forms of psoriasis. The indirect immunofluorescence method was used on histological sections of human kidney and mouse liver and kidney. This method was also used with sera from children with coeliac disease and from healthy controls. In 10 these antibodies were positive, while in 22 they were negative, the intensity of the titres varying with the extent of the disease. These results support the notion that immunological phenomena may be involved in the physiopathological mechanisms of psoriasis.

Adolescent↗
PubMed1980

[Propionibacterium acnes in acne vulgaris (comparative biochemical study of the comedone and the pustule].

The biochemical properties of the Propionibacterium acnes in 22 patients with inflammatory Acne vulgaris was studied. Group I/II was found in most cases. There was no difference between the biochemical properties of the comedone and the pustule. The authors suggest that factors other than those depending on the PA degradative metabolism can be responsible for the purulent inflammatory process of the pil-sebaceous follicle.

Acne Vulgaris↗
PubMed1980

[Leukocyte migration inhibition factor in acne vulgaris].

The inhibition factor of the leucocytic migration was studied in 26 patients with Acne Vulgaris, stages III and IV, being positive in all the cases. The LIF positive shows the mobilisation of lymphocytic population, answering an active and constant immunologic conflict. As the PA is antigenic, because it produces a blastification (TTL positive), we can say that it acts as antigen provoking immunologic mechanisms which help to explain the inflammatory processes at the pilo-sebaceous follicle in the AV.

Acne Vulgaris↗
PubMed1977

[Blastogenic response in vitro of lymphocyte acne vulgaris].

32 patients with different degrees of acne and 10 healthy controls were studied. On every one of them the test for lymphocytic transformation was performed looking for the range of blastogenic response, using PHA and CA. The positive findings with CA related to those obtained in normal subject would support the hypotesis that the cellular immunity as a response to CA antigens would be different in each patient according to the host local conditions.

Acne Vulgaris↗
PubMed1977

[The nitro-blue-tetrazolium test in acne vulgaris (9-12-77)].

41 patients with different AV stages were studied with the quantitative NAT test. In those cases where there was an inflammatory process (stages III and IV) it was positive, while in was negative. The authors consider the relation between this test and the positive Lymphoblastic Transformation Test to PA, which makes evident a coordinate action of the immune specific system and the granulocytic one. This facts show that AV at the inflammatory stage is an immunologic systemic process and not only a local one.

Acne Vulgaris↗
PubMed1977

[The inhibitor factor of leukocyte migration in acne vulgaris].

The inhibition factor of the leukocytic migration was studied in 26 patients with Acne Vulgaris, stages III and IV, being positive in all the cases. The LIF positive shows the mobilisation of lymphocytic population, answering an active and constant immunologic conflict. As the PA is antigenic, because it produces a blastification (TTL positive), we can say that it acts as antigen provoking immunologic mechanisms with help to explain the inflammatory process at the pilosebaceous follicle in the AV.

Acne Vulgaris↗