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Biomedical subjects

R A Vishwakarma

Publications and source records attributed to R A Vishwakarma.

22 records · Page 2Linked to original sources
PubMed1989

Artemisinin (qinghaosu)--a new gametocytocidal drug for malaria.

Gametocytocidal activity of artemisinin (qinghaosu) has been demonstrated against simian malaria parasite Plasmodium cynomolgi B. Colony-bred Anopheles stephensi were allowed to feed on gametocyte-carrying rhesus monkeys and the mosquito infectivity rate and oocyst count of the infected mosquito gut were recorded on day 8-9 postinfection. Control (pretreatment) feedings of mosquito on gametocyte-carrying monkeys showed good infectivity in different batches of the mosquitoes ranging from 57.14 to 95.0%. Administration of single intramuscular injection of 5 mg/kg artemisinin (suspended in neutralised oil) resulted in complete loss of mosquito infectivity within 24 h of drug administration. This is the first report on the possible use of artemisinin to stop malaria transmission. The drug has no sporontocidal action.

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PubMedDate not supplied

Comparison of antimalarial efficacy of artemisinin (qinghaosu) and arteether against Plasmodium cynomolgi B infection in monkeys.

Arteether (30:70 mixture of alpha and beta epimers) used as injectable intramuscular preparation (in neutralized ground-nut oil) had curative action at 5 mg/kg x 3 d against blood-induced Plasmodium cynomolgi B infection in rhesus monkeys, while the curative dose of artemisinin (qinghaosu) oil suspension was 10 mg/kg x 7 d or 20 mg/kg x 3 d. Parasite clearance with arteether was achieved within 24 h. Neither arteether nor artemisinin exhibited any causal prophylactic or radical curative action up to dose levels of 20 mg/kg against sporozoite-induced P. cynomolgi B infection in rhesus monkeys.

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PubMedDate not supplied

Antimalarial efficacy of arteether against multiple drug resistant strain of Plasmodium yoelii nigeriensis.

New quick-acting blood schizontocides are needed to contain the spread of multiple drug resistant strains of P. falciparum and for the treatment of the cerebral malaria cases. A multiple drug resistant strain of P. yoelii nigeriensis resistant to mefloquine (128 mg/kg x 6 days), quinine (300 mg/kg x 7 days) and chloroquine (64 mg/kg x 8 days) was found to be completely susceptible to arteether (a 30:70 mixture of alpha and beta enantiomers) and a dose of 5 mg/kg x 3 days by i.m. route was curative in Swiss mice. Artemisinin at 50 mg/kg x 7 days had only suppressive action against this strain.

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