PubMed Health⌕ Search

Biomedical subjects

R AIMAN

Publications and source records attributed to R AIMAN.

18 recordsLinked to original sources
PubMed1961

Antihistaminase activity of serpentine.

Serpentine, an alkaloid of Rauwolfia serpentina, specifically potentiates histamine responses of guinea-pig ileum, uterus, and tracheal chain. It also inhibits histaminase in vitro. Its antihistaminase activity is equivalent to that of aminoguanidine.

Alkaloids↗
PubMed1959

Mechanism of action of oral antidiabetic drugs.

The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.

Alloxan↗
PubMed1957

The effect of human plasma on the glucose uptake of the rat diaphragm before and after administration of carbutamide.

The glucose uptake of the rat diaphragm has been determined in the presence of the plasma of young volunteers before and after administration of carbutamide without and with added insulin. The increase in the glucose uptake of the rat diaphragm due to the added plasma above that in the medium alone has been termed plasma effect. The increase in the glucose uptake of the rat diaphragm with plasma and added insulin above that with only insulin in the medium has been termed plasma+insulin effect. There was a significant increase in the plasma effect and the plasma+insulin effect after carbutamide administration. The increase in the plasma+insulin effect was significantly greater than the increase in the plasma effect. From these observations it has been suggested that carbutamide potentiates the action of insulin peripherally. Observed facts about carbutamide do not contradict this mechanism of action.

Animals↗