Phylogeny of the neurohypophysial hormones. Two new active peptides isolated from a cartilaginous fish, Squalus acanthias.
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Biomedical subjects
Publications and source records attributed to R Acher.
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Neurohypophysial hormones have been so far identified in Neopterygii and Crossopterygii but not in species of the bird sub-class of bony fishes, the Palaeopterygii. Isolation and chemical characterization of the active principles of a primitive bony fish, Polypterus bichir, have been performed. Isotocin (Ser(4)-Ile(8)-oxytocin) and arginine vasotocin (Arg(8)-oxytocin) have been identified. Because the same peptides were found in the recent Neopterygii, it can be deduced that neurohypophysial hormones have displayed a peculiar stability in the course of the evolution of bony fishes. However isotocin and vasotocin are replaced by oxytocin and vasopressins in mammals and therefore might be regarded as "old" molecules.
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A toad (Bufo bufo) hemoglobin has been purified and two types of chain have been separated by counter-current distribution. The alpha-chain has a N-terminal sequence Ac-Ala-Leu and a C-terminal sequence Tyr-Arg. The beta-chain has a N-terminal sequence Val-His-Leu and a C-terminal sequence Tyr-His.
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