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Biomedical subjects

R Adie

Publications and source records attributed to R Adie.

5 recordsLinked to original sources

Prolonged control of hypoglycaemia by L-asparaginase in islet cell carcinoma producing insulin and gastrin.

L-asparaginase (140,000 units) infused into the hepatic artery resulted in a remission from disabling hypoglycaemia for nine months in a man with islet cell carcinoma of the pancreas and hepatic metastases. The tumour produced insulin and gastrin with resulting hypoglycaemia and recurrent peptic ulceration which were unresponsive to other drugs. Following L-asparaginase there was a fall in both plasma and insulin and gastrin.

Adenoma, Islet Cell

Combined thyroxine and triiodothyronine for thyroid replacement therapy.

Tablets containing 50mug. of thyroxine and 15mug. of triiodothyronine have been used to treat patients with hypothyroidism of varied aetiology. Following total thyroidectomy a daily dose of three tablets-that is, 150mug. of thyroxine and 45mug. of triiodothyronine-maintained patients in a euthyroid state and produced a protein-bound iodine level within the normal range. The preparation is preferable to dried thyroid because of uniformity of activity and speed of action, and when the patient is clinically euthyroid the P.B.I. falls within the normal range.

Blood Proteins