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Biomedical subjects

R Agricola

Publications and source records attributed to R Agricola.

11 recordsLinked to original sources
PubMed1984

A preliminary study on the use of calcitonin in clinical psychopathology.

After having reviewed the properties of calcitonin (Ct), a hormone involved in calcium-phosphate metabolism and bone turnover, mention is made of the effects of Ct at the level of the CNS and its role as a neuromediator interfering with endorphins, prolactin, dopamine and the Ca concentration of the CSF. Overall's rating scale was used to evaluate the effects of synthetic salmon Ct in nine subjects with severe depression syndromes refractory to normal therapy. The study demonstrated statistically significant improvements of the major symptoms (behavioural excitation, depression, agitation, anxiety and affectivity). The favourable results justify broader and more detailed studies involving the relationship between Ct and psychopathology.

Adult↗
PubMed1982

Treatment of acute alcohol withdrawal syndrome with carbamazepine: a double-blind comparison with tiapride.

A double-blind, randomized trial is described which was designed to compare the clinical effect of 600 mg daily of carbamazepine (Tegretol) and of tiapride (Sereprile) in hospitalized patients with pre-delirium tremens. Physicians' assessment of patients' progress was made following 2, 4 and 7 days of treatment. Of the sixty patients admitted to the study, five dropped out for various reasons, leaving fifty-five patients who completed the study. Both drugs were effective in the treatment of alcohol withdrawal symptoms; no significant difference was found between the two treatments with respect to total symptoms, score and visual analogue scale assessment. Carbamazepine gave faster relief of symptoms and demonstrated a preferential action on symptoms like fear and hallucinations. No case of delirium tremens was observed in those patients who completed the trial.

Adult↗
PubMedDate not supplied

[Blood lysozyme level and bone marrow granulocyte reserve].

The relation between granulocyte turnover, as shown by serum lysozyme values, and the marrow granulocyte reserve, evaluated by means of the hydrocortisone test, was determined in 20 patients with metastasised solid tumours or lymphomas undergoing cytostatic and/or radiation management. In addition to confirming the validity of this test as a means of assessing the behaviour of the marrow storage compartment, it pointed to a correlation between the hydrocortisone test and serum lysozyme. High enzyme values, in fact, insofar as they are an expression of accelerated granulocyte turnover may be seen as an indication of reduced marrow function, and thus offer a simple means of predicting reduction of the marrow granulocyte reserve, and hence a possible post-chemotherapeutic leukopenia, in some cases where peripheral leukopenia is not apparent.

Antineoplastic Agents↗