Biomedical subjects
R Ambriz-Fernández
Publications and source records attributed to R Ambriz-Fernández.
[Opportune treatment of hemorrhage in classical hemophilia. Study of the Hemophilia Cooperative Group].
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[Results of treatment with 2 chemotherapeutic protocols (TAPA and VAPA) in acute myeloblastic leukemia].
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[Use of a basic study profile for diagnostic certainty in hemophilia A].
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[Splenectomy in chronic granulocytic leukemia].
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[Idiopathic thrombocytopenic purpura in 225 adult cases. Use of delayed action prednisone in chronic purpura].
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[Sideroblastic anemia in lead poisoning].
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[Hemophilic arthropathy. The therapeutic approaches in the clinical picture of hemophilia].
The ambulatory treatment of hemophilic arthropathy decreased the amount of replacement therapy with factor VIII from 3,220,000 U in 1984 to 2,217,700 U (32%) in 1988. Radioactive synovectomy diminished the number of hemarthroses in 97 per cent. Intraarticular dexamethasone reduced bleeding episodes and improved joint function in 48 per cent. These procedures for hemophilic arthropathy allowed to integrate the patient into society and diminished transfusion risks.
Danazol in refractory autoimmune thrombocytopenic purpura (ATP). A new therapeutic sequence.
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Kinetics of the inhibitor of factor VIII:C in patients with hemophilia A. A study of the cooperative group of hemophilia.
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Coagulation factors V and VII combined congenital deficiency in a Mexican family: Toledo-Tehuantepec deficiency, a new pathological entity.
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[Multiple cartilaginous exostoses in a family. Relation of its complications and association with coagulopathies].
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[Factor V deficiency (parahemophilia) in a Mexican family. First report from Mexico].
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[Efficacy of a bolus of methyl-prednisolone in acquired recurrent refractory pure red cell aplasia].
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[Cause of death in acute leukemia. Analysis of 224 cases].
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[Utility of desmopressin in 4 cases of thrombocytopathies associated with giant platelets].
Shear-induced aggregation requires the platelet glycoprotein complexes (Gp), the von Willebrand factor (vWf) and ADP. The Bernard Soulier syndrome (BS) and the gray platelet syndrome (GPS) are platelet function defects characterized by absence of GP Ib/IX and alpha granules, respectively, with mucocutaneous hemorrhages, prolonged bleeding time (BT) and moderate thrombocytopenia in both syndromes. There are reports that desmopressin (DDAVP) shortens the BT in some patients with platelet dysfunction. The purpose of this study was to evaluate the response t(DDAVP) in four female patients (2 with GPS plus Marfan's disease and 2 BS). All had bleeding episodes, BTs > 10 minutes, platelet counts (PC) between 40-88 x 10(9)/L and defects in platelet aggregation. The DDAVP was administered at a dose of 0.3 microgram/kg in 15 to 30 mL of isotonic saline given by slow intravenous drip in 30 to 45 min. All patients were studied before and after DDAVP administration (BT, PC, platelet factor, mean platelet volume, factors F.VIII:C, FvW:Ag, FvW:RiC of, and platelet aggregation). After DDAVP infusion the patients had a BT < 6 min, and increased levels of F. VIII:C, FvW:Ag and FvW:RiC of (> 100 Ul/dL), and the bleeding disappeared. We conclude that there was a good response to DDAVP probably associated with improved platelet adhesion, and increases in the multimers of the von Willebrand factor.