[On psyche, Skinner boxes and science].
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Philosophy↗
Biomedical subjects
R Amundsen
Publications and source records attributed to R Amundsen.
Increased beta-thromboglobulin in essential hypertension: interactions between arterial plasma adrenaline, platelet function and blood lipids.
Twenty-three 50-year-old men with untreated, essential hypertension had elevated plasma concentrations of the platelet release product beta-thromboglobulin (BTG) compared to 14 age-matched control men (p less than 0.01). BTG correlated with arterial plasma adrenaline concentrations in the hypertensive (r = 0.44, p less than 0.05), normotensive (r = 0.73, p less than 0.01) and combined group (r = 0.51, p less than 0.01). Significant correlations (p less than 0.05) between BTG and cholesterol (LDL + VLDL fraction) were observed both in the hypertensive and the normotensive group. In the hypertensive group arterial adrenaline correlated with cholesterol (LDL + VLDL) (p less than 0.05). These findings are consistent with increased platelet activity in middle-aged men with essential hypertension, and may indicate that plasma adrenaline influence platelet function. The risk factors for coronary artery disease (blood pressure, lipid status, stress as evidenced by catecholamine release and platelet function) were positively related. Measurement of arterial instead of venous adrenaline is essential for the demonstration of the associations presented.
Beta-Globulins↗
Increased plasma free dopamine after treatment with atenolol and oxprenolol in essential hypertension.
In 19 men aged 50 with essential hypertension, 18 weeks' treatment with atenolol (n = 9) or oxprenolol (n = 10) increased supine plasma free dopamine concentrations by 78% (p less than 0.05) and 121% (p less than 0.001) respectively. Increments in plasma dopamine were observed in all patients except for one treated with atenolol. Supine peripheral venous adrenaline and noradrenaline concentrations were not influenced by beta-blockade. The mechanism and significance of the present elevation of plasma free dopamine by beta-blockade are unknown. However, increased plasma free dopamine may be involved in the hypotensive effect of chronic beta-adrenergic blockade, both beta-1 selective and non-selective, and may lend further support to decreased dopaminergic activity in essential hypertension.
Atenolol↗
The contribution of embryo extract to myogenesis of avian striated muscle in vitro.
Myogenesis of avian striated muscle in vitro requires the presence of serum and embryo extract. The serum requirement can be satisfied by insulin. Embryo extract contributes at least two factors, one of which promotes the fusion of myoblasts, whereas the other promotes the development of myotubes.
Animals↗