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Biomedical subjects

R Andión Dapena

Publications and source records attributed to R Andión Dapena.

6 recordsLinked to original sources
PubMed1993

[Increased serum levels of soluble IL-2 receptor in food intolerance: possible mechanism of delayed immunity in milk intolerance].

The levels of soluble interleukin-2 receptor (sIL-2R) were measured in 35 serum samples from children with food intolerance; 19 had an IgE-mediated sensitization and were considered as atopic patients, skin tests and RAST were negative in the remaining 16 children and they were diagnosed as having cow milk intolerance (CMI) Forty-three coeliac patients were included as a positive control group and 18 normal children as the negative control group. The atopic group showed normal values of sIL-2R (1,183 +/- 468 u/ml); however, it was increased in children with CMI (1,453 +/- 469 u/ml, p < 0.05). The sIL-2R mean value was highest in patients with gastrointestinal symptoms (1,458 +/- 461 u/ml, p: 0.03) and the presence of atopic dermatitis was not relevant. The sIL-2R was also elevated in 8 children with igE-mediated sensitization against cow's milk (1,477 +/- 328 u/ml, p < 0.05). These results suggest that a delayed cellular mechanism occurred in CMI, similar to that present in coeliac disease, although it was less severe. In addition, there is an overlap of humoral and cellular immunological mechanisms in the IgE-mediated sensitization to cow's milk, but we did not find this coincidence in the allergy to remaining foods. From a pathogenic point of view, to separate CMI from IgE-mediated allergies to milk does not seem to be sufficiently justified at the present time. It is possible that the atopy against cow milk proteins in children has a different immunological mechanism than the atopy to other foods, which would explain its better prognosis.

Adolescent↗
PubMed1987

[Non-specific triggering factors in 197 non-pollenogenic asthmatics with an unfavorable outcome].

One hundred and ninety seven, non-pollenic, asthmatic patients showing asthma or other respiratory allergic symptoms 5 years after the date of the diagnosis, were studied. Several non-specific trigger factors which could be the cause of the inadequate outcome were investigated. In 93 cases (47%) had respiratory infections previous to asthmatic crisis; in 66 (33%) had home or climatic changes; in 54 (27%) there was impairment subsequent to physical exercise and 13 (7%) had irritants factors at home. Other interesting epidemiological data were the male sex (69%) and the allergic familial antecedents (55%). Among the 197 patients 53 were secondarily sensibilized to pollen during the 5 years follow-up, 20 did it to foods and 14 to danders. Children sensibilized to foods and epithelia allergens had a similar behaviour to the general group. Patients secondarily sensibilized to pollen showed differences: Respiratory infections and physical exercise climatic changes were more frequent. They also had a more lasting natural lactation.

Adolescent↗
PubMed1986

[Natural history of pollinosis in childhood].

Out of 2.513 clinical files of allergic children, we have found 200 pollen-allergic patients, which represent 7.9% of the total allergic pathology in children, in our environment. We have studied in these 200, the most important epidemiological parameters and the influence that this can cause upon the characteristics of this disease. A male predominance has been found (70%) and it has been discovered that 52% of the total were born in spring (p less than 0.0005). An hundred per cent have shown grass-pollen sensitiveness and 52% have also shown other kinds of pollen hypersensitivity. It has been found familiar allergic background in 76.5% of the cases and in 32.5% familiar allergic history of pollinosis. Unexpectedly, those who were in lack of familiar allergic history began their clinical symptoms earlier; 51.06% before 6 years of age (p less than 0.05). Other kinds of allergic manifestations were found in 51%, being respiratory symptoms the most important (35.5%), followed by the cutaneous (23.5%) and digestive ones (10.5%). Allergy to drugs was found in 10.5%. The more frequent symptoms of pollinosis were in order of importance: rhinitis (86.5%), conjunctivitis (77%), asthma (48%), spasmodic cough (27.5%) and urticaria (4%). Asthma induced by grass-pollen hypersensitivity was equally suffered by the males as by the females, and this was more frequent among the patients who had previously suffered from non-pollinic respiratory allergies.

Adolescent↗
PubMed1977

[Intestinal immunity system and alimentary allergy (author's transl)].

Thirty seven intestinal biopsies from twenty-one food-allergic and sixteen control children were studied by immunofluorescence and the density of IgA, IgM, IgG and IgE forming cells (F.C.) in the lamina propria determined. In order to compare the results in allergic and normals the authors establish three age-groups: under 9 mo., 9 to 24 mo. and older than 24 mo. A higher density of IgM F.C. were found in allergic patients from the first group. Allergic children from all groups had more IgE F.C. but the figures were only significant for children older these two years. IgA F.C./IgE F.C. ratio was bover in allergic than in controls (p than less 0.02) after the age of 10 mo. Sone comments on these findings are made.

Age Factors↗