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Biomedical subjects

R Andrianne

Publications and source records attributed to R Andrianne.

At least 19 recordsLinked to original sources

[Consensus on the clinical approach to erectile dysfunction in patients with cardiovascular disease].

The most common physical risk factors for erectile dysfunction (ED) are atherosclerosis, heart disease, hypertension and diabetes. Since accessibility to easy and efficacy drug for ED therapy, GPs are increasingly at the front line in the management of ED and are often best-placed to discuss this problem with cardiovascular male patients. This consensus aims to provide practical advice on the management of ED in patients with diagnosed cardiovascular disease and also addresses the assessment of the cardiovascular risk in restoring sexual activity in these patients. A risk assessment algorithm has been drawn up to aid clinicians in deciding the level of cardiovascular risk that would be associated with a return of sexual activity as well as criteria for referral to specialists for further cardiac evaluation. Treatment options are briefly reviewed and follow-up process identified.

Adult↗

[Drug of the month. Sildenafil (Viagra)].

Sildenafil (Viagra) from Pfizer (UK-92,480) is a competitive and selective inhibitor of cyclic GMP specific type 5 phosphodiesterase. Male erectile dysfunction is defined as "the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance". Sildenafil (Viagra) is effective in a significant proportion of patients with erectile dysfunction. Patients should be instructed to take a dose from 25 to 100 mgrs approximately 30 to 60 minutes before sexual activity, but no more than once daily. Sexual stimulation is necessary to produce erectile reaction. The safety and tolerance of sildenafil have been demonstrated. However, prior to initiating treatment with sildenafil, physicians should consider the cardiovascular status of their patients, particularly for patients with unstable coronary heart disease or concomitant treatment with nitrates.

3',5'-Cyclic-GMP Phosphodiesterases↗

[Surgery, radiotherapy or hormonal therapy in the treatment of prostate cancer].

Prostatic cancer (PC) became the first diagnosed cancer in western men and is the second leading cause of cancer death in men. Wide utilisation of serum PSA and free PSA measurements, identifies patients requiring transrectalultrasonography (TRUS) and TRUS guided biopsies. Most prostatic cancers diagnosed today are locally limited and may be treated by radical surgery or radiotherapy. In case of disseminated disease, hormonal manipulations remain the treatment of choice. In that field, many new drugs have been designed to allow medical castration with less complications, especially regarding sexual potency.

Adult↗

[Results of artificial sphincter for the treatment of sphincter incontinence].

47 patients were treated since 1987 by implantation of an artificial sphincter. The majority of female patients were operated for bladder neck hypermotility. In the male population, incontinence was mostly a complication of prostatic surgery. The indication, preoperatory assessment, surgical techniques and results are discussed. During a mean follow-up of 38 months, 92.9% of females remained perfectly continent and results were good in 76.7% of males. The results are similar to those reported in the literature.

Female↗

[Antegrade scrotal embolization of varicocele: results].

The aim of this study is to judge the effectiveness of the new treatment of varicoceles, introduced in 1987 by Tauber: the antegradal scrotal sclerotherapy of varicoceles. From february 1996 to april 1998, we have realised 150 antegrade embolisations of varicoceles. The study is lead on 75 patients with mean time follow-up of 12 months. Patient's mean age is 20 years. 85% of patients had a grade 3 left varicocele and 15% a grade 2 left varicocele. The criterium of success rests on the lack of veinous flow-back during clinical examination, which is than confirmed by doppler-ultrasound. Clinical success is obtained in 87% of the cases and the doppler control is normal in 80% of the cases. We have 9% of minor complications, and no major complication. The number of failures in our study is higher than in Tauber' study, but is the same as those described in the other procedures of treatment of varicocele. On the other hand the surgical procedure is simple and the morbidity is low.

Adolescent↗

[Results of artificial sphincter in a case of sphincter incontinence in the multiple surgery patient].

Stress incontinence represents 77 to 91% of female urinary incontinence, 10% of witch are sphincterial incontinence. The specific treatment of sphincterial incontinence is of periuretral injections or calls for an artificial sphincter. We present the retrospect of 12 patients having undergone several surgical treatments and having at last the benefit of an artificial sphincter since 1990. In majority, these patients had been operated for bladder neck hypermobility. The indication, preoperatory evaluations, surgical technics and results are discussed. During the mean follow-up of 40.5 months, 91.7% of patients are perfectly continent. The results are equal to those of other publications.

Adult↗

Uretero-arterial fistula: two observations.

Two cases of life-threatening haematuria, secondary to an uretero-arterial fistula, are reported. Both cases present predisposing causative factors. One patient had a combination of previous aorto-bifemoral bypass grafting, an iliac artery aneurysm (retrogradely perfused), and an indwelling ureteral stent for ureteral compression. The other patient had previous aortoiliac surgery and obstructive uropathy with chronic urinary tract infection. Preoperative diagnosis of uretero-arterial fistula was made in only one patient. He was successfully operated (exclusion of the iliac aneurysm). In the other patient, nephrectomy was attempted to control reno-ureteral bleeding of unknown origin. Fatal recidive of brisk haematuria occurred some days later. Factors contributing to the development of uretero-arterial fistula, their diagnosis and optimal treatment are discussed.

Aged↗

[Recurrent urethral stenosis treated with a Urolome Plus stent implantation: intermediate multicenter follow-up].

We present the medium-term results of 33 patients treated with Urolume Plus urethral stent between August 1990 and June 1996 in 9 Belgian and Luxembourg centers. They all had previous treatments for bulbo-membranous urethral stricture, but without sustained benefit (dilatation, internal urethrotomy, or/and urethroplasty). The mean age of the stricture was 5.4 years (+/- 4). The stent was inserted easily during a short hospitalisation. Median time of follow-up is two years (6 months to 4 years). Maximum flow rate at last follow-up was 20.7 ml/sec (+/- 7), and 83.3% of the patients were satisfied with the stent. In 70% of the cases, the stent achieved its purpose of maintaining a good urethral lumen. In 5 patients (15.15%), stricture recurred inside the stent and in 2 patients (6.06%) a new stricture appeared on another site. Among these 7 patients, 5 were satisfactorily treated by endoluminal resection (4 cases) or dilatation (1 case). There were 2 real failures (= 6%): one patient who has refused any complementary endoscopic treatment and the other one who is still undergoing repeated urethral dilatations. Having respected the right indications for this device, we are satisfied of the results. It is a good alternative after failure of other treatments for bulbar-membranous stricture.

Anesthesia↗

[Efficacy of Doppler color echography in the diagnosis of caverno-venous leakage in the impotent patient].

Duplex sonography is now the gold standard for the non-invasive study of cavernous arteries. Many authors consider that this technique allows for the exploration of the veno-occlusive system and can detect venous leakage. The most common criteria is an end diastolic velocity > 5 cm/s, measured in the cavernous arteries. In a retrospective study, 34 impotent patients were reviewed. All of them were explored both by doppler sonography and pharmacocavernosometry to assess the efficacy of duplex sonography in detecting venous leakage. The data show that the doppler detects venous leakage in only 41%. The specificity and the sensitivity are both 50% which is clearly disappointing. Therefore, in our experience, duplex sonography is not a reliable technique to detect venous leakage. We consider that the best method is still pharmacocavernosometry.

Arteries↗

[Preliminary results of extracorporeal lithotripsy under local anesthesia using a multimodal generator (Tri-gen Compact Direx C)].

From April till October 1994, 64 patients were treated with the new generation of Direx lithotriptors, the Trigen Compact. The treatment was given in one-day clinic. The preparation is made of an intravenous hydratation, Dipidolor intra-muscular, Voltaren intra-rectal and Emla on the skin in the area of the shocks. Only 38 patients are estimated at three months. The first results are encouraging, with globally 78% of good results (stone free or residual fragments inferior to 5 mm) and 22% of failure. The best results (90%) are obtained with the ureteral stones. The results of the treatments of caliceal and pyelo-lithiasis are a little bit less good, with respectively 78 and 71% of good results. These data should become better when all the patients will be estimated at 3 months.

Anesthesia, Local↗

[Penile prosthesis in case of impotence: 12 years of clinical experience].

Among 95 patients who have received a penile prosthesis between 1982 and 1993 (mean follow up of 46 months), 21 (22%) presented complications requiring one or more reintervention(s). Only for two patients the problem was mechanical, in the majority, they were non mechanical. Five of those subjects (5.5%) presented such complications that definitive explanation of the device was necessary. The problems presented by the 9 remaining patients were fully satisfactorily managed. Presently 94.5 per cent of the patients are using the device. Follow-up study of our interdisciplinary group demonstrates the efficacity of the prosthesis for revitalisation of the couples. The definitive parameters of implantation acceptance are essentially the partner influence and the treatment cost. This clinical study shows that the implantation of a penile prosthesis is an effective therapy in the treatment of impotence in a selected population. Presently, the mechanical reliability of different device has been good to date.

Adult↗

The experience of the CHU Liège with conservative surgery in the management of upper urinary tract tumors.

A review of 20 cases of conservative surgery for urothelial tumors of the upper tract is presented. The morbidity is limited; the recurrence rate is around 15% in the ipsilateral urinary tract with a mean follow up of 41 months. Conservative surgery does not seem to carry a higher fatal risk as compared to more radical surgery. It has indications in some cases which are defined.

Adult↗

[Preliminary experience in laparoscopic nephrectomy].

The laparoscopic technic of nephrectomy and nephroureterectomy is presented. We discuss about the indications and contraindications of this technic. Then we present our results about our first 6 cases. We concluded that this new technic is very beneficial to the well selected patient concerning the post-operatory comfort and the early revalidation period.

Adenocarcinoma↗

The experience of radical prostatectomy for locally confined prostate cancer in Liège.

The authors report their experience of 148 radical prostatectomies performed for adeno-carcinoma. They expose the reasons which have led them to adopt this kind of treatment and the reasons explaining a nearly exponential increase of the frequency of the operation during the last 5 years. They underline the importance of lymphadenectomy and the safety of frozen sections of the nodes. The surgical technique is briefly commented and the (low) morbidity of the operation is reviewed. They compare the results of RPV to those of external radiotherapy, watchful attitude or immediate hormonal treatment and they conclude in insisting on the benefit of the surgical approach as far as indications (which are defined) are strictly followed.

Adenocarcinoma↗

Original lithotomy positioning for transperineal extracorporeal shockwave lithotripsy for distal ureteric calculi with Tripter X1.

Extracorporeal shockwave lithotripsy (ESWL) has been initially designed for stones located in the kidney and the upper ureter. Our lithotripter is no exception. Its components (the table and the orientation of the semi-ellipsoid reflector) are adapted for the treatment of kidney or lumbar ureter stones. However, the elements forming the unit of treatment (the table, the C-arm and the Tripter) can be modified in such a way that focalization of stones of the lower ureter becomes possible through a perineal exposure. The aim is to avoid the pelvic bone shield while a good focalization of the stone is realized. From June 1989 to March 1991, 35 patients were treated for distal ureteric stones by ESWL in this original positioning.

Adolescent↗

[Ureteroscopic resection of a fibrous polyp of the ureter].

From a new case of fibroepithelial polyp in a 41 year old woman, we reviewed literature on this rare and benign pathology, for which differential diagnosis with malignant tumor is most often obtained surgically. We emphasize both diagnostic and therapeutic advantages of endoscopic approach of this lesion.

Adult↗