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Biomedical subjects

R Anner

Publications and source records attributed to R Anner.

7 recordsLinked to original sources
PubMed2005

The clinical effectiveness of 6 mm diameter implants.

BACKGROUND: Five- and 6 mm diameter screw-type endosseous implants have been used for the last decade. While some studies have reported very promising results (94% to 98% success rate), others have demonstrated survival rates below those clinically acceptable (75% to 87%). Moreover, such implants have been associated with increased cervical bone resorption and thread exposure. METHODS: Between June 1999 and July 2003, 43 patients received treatment with 6 mm diameter tapered hydroxyapatite (HA)-coated implants. A total of 45 implants were placed. All patients were recalled annually after implant exposure. One patient was lost to follow-up after 1 year. Forty-four implants were evaluated at the recall examinations. All implants supported a fixed prosthesis; in the majority of patients (35 implants), it was a single-tooth fixed prosthesis. The mean loading time was 23.4 months (range, 1 to 54 months). RESULTS: No implants were lost during the loading period. The overall survival rate was 100%. Crestal bone remodeling was examined using periapical radiographs. After a mean of 23.4 months in function, only one implant presented bone loss beyond the first thread. CONCLUSIONS: This study showed that high survival rates can be obtained after prosthetic treatment with 6 mm-wide tapered HA-coated implants. Long-term prospective studies are needed to confirm these results.

Adult↗
PubMed1986

Serum protein binding of diazepam and propranolol in the feto-maternal unit from early to late pregnancy.

Paired samples of maternal and fetal serum were obtained in 65 pregnancies between 13 and 41 weeks gestation. Concentrations of albumin, alpha 1-acid glycoprotein (alpha 1-AGP) and free fatty acids (FFA) were estimated in all samples and the in-vitro binding of diazepam and propranolol was estimated. The free fraction of diazepam in fetal serum was very high in early gestation and decreased with advancing gestation to reach maternal values around the 30th week. After 35 weeks gestation, values were generally lower in fetal than in maternal serum. Fetal serum binding of diazepam correlated with fetal albumin levels and gestational age. The ratio of the fetal/maternal free diazepam fraction correlated negatively with the fetal/maternal serum albumin concentration ratio. The maternal/fetal free diazepam fraction ratio correlated positively with gestational age. The free fraction of propranolol in fetal serum was higher than in maternal serum in early pregnancy and decreased with advancing gestation but always remained higher than the maternal values. The fetal/maternal free propranolol fraction ratio was negatively correlated with the fetal/maternal alpha 1-AGP serum concentration ratio. The maternal/fetal free propranolol fraction ratio was positively correlated with gestational age. Serum protein binding of propranolol was correlated with serum albumin concentrations in fetal samples but not in maternal samples. Serum FFA concentrations were not correlated with serum protein binding except for maternal serum binding of diazepam. For toxicological reasons it is advisable to monitor maternal blood for free concentrations of drugs that exhibit concentration-dependent protein binding or which can be displaced from binding sites by other drugs or endogenous compounds such as FFA.

Adolescent↗
PubMed1985

[Prevalence of 7 microorganisms in abnormal vaginal secretions (vaginitis)].

Seven microorganisms (N. gonorrhoeae, C. albicans, T. vaginalis, G. vaginalis, M. hominis, U. urealyticum and Streptococcus of group B) have been assayed in genital samplings of 164 asymptomatic women (control group) and of 374 women suffering from abnormal vaginal secretions (vaginitis group). All these bacteria except group B Streptococci were isolated in the vaginitis group more frequently than in the control group (p less than 0.01). The proportion of negative cultures for all tested bacteria was 39% in the control group and 6.4% in the vaginitis group (p less than 0.01). This shows an association of these bacteria with 70% of the patients of the vaginitis group and with only 26% of the women of the control group (p less than 0.01). It is to be noted that the pH values are higher in the group of women with vaginitis than in the control group (p less than 0.01). Comparison of the microbial flora during "specific" an "non-specific" vaginitis indicates that G. vaginalis is isolated more frequently in patients with non-specific vaginitis than among those with specific vaginitis (p less than 0.01). Likewise, M. hominis is isolated more frequently in groups of women with either non-specific vaginitis or T. vaginalis vaginitis, than in groups of patients with a C. albicans vaginitis (p less than 0,01). The results of this study indicate that there is a causal relationship between vaginitis and the presence of T. vaginalis. C. albicans, G. vaginalis, M. hominis or N. gonorrhoeae, either as a single or a mixed infection, and that there is a relationship between increased pH values and abnormal vaginal secretions.

Adult↗
PubMed1984

Changes in serum albumin and alpha 1-acid glycoprotein concentrations during pregnancy: an analysis of fetal-maternal pairs.

The concentration of the two principal drug-binding proteins, albumin and alpha 1-acid glycoprotein, were measured in 44 paired fetal and maternal serum samples obtained at between 12 and 41 weeks gestation. Maternal serum albumin concentrations ranged between 25 and 35 g/l during this period. Fetal serum albumin was much lower in early gestation, ranging from 7.5 to 16 g/l at 12-15 weeks. With advancing age there was a linear increase so that at 30 weeks the fetal and the maternal serum albumin concentrations were in the same range and after 35 weeks the fetal concentrations exceeded the maternal by some 20%. Thus, the mean fetal/maternal serum concentration ratio of albumin increases from early pregnancy to term: 0.38 at 12-15 weeks; 0.66 at 16-25 weeks; 0.97 at 26-35 weeks; and 1.2 at greater than 35 weeks gestation. Maternal serum alpha 1-acid glycoprotein concentrations were scattered widely between 0.38 and 1.05 g/l. With the technique used fetal serum concentrations were hardly detectable before 16 weeks. Thereafter they increased at a constant rate, but never attained the maternal values. Near term a fetal/maternal serum concentration ratio of 0.37 was reached. These changes in protein concentrations may have important pharmacological implications.

Adolescent↗