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Biomedical subjects

R Antonini

Publications and source records attributed to R Antonini.

33 records · Page 2Linked to original sources

Uterine blood flow and prostaglandin levels in ovariectomized rabbits.

Blood flow (measured by radioactive microspheres) through the uteri of ovariectomized rabbits increased significantly by 2 h, was lower at 4 and 8 h, and returned to control values by 24 h after an injection of 25 microgram oestradiol-17beta. Blood flow through the kidneys was not affected. Concentrations of PGF and PGE in uterine vein blood were elevated after oestrogen treatment. PGF values were significantly greater than control. PGE concentrations, while elevated, were not significantly different from control, although the pattern of release was similar to that of PGF. Pretreatment of animals with progesterone or L11204, or concurrent treatment with indomethacin did not modify the blood flow through the uterus. It is concluded that the increased uterine blood flow seen after oestrogen treatment is not related to prostaglandin production.

Animals↗

Open abdomen liver biopsy by a modified one-second technic.

With the purpose of facilitating liver biopsy during upper abdominal procedures, an adaptation of the percutaneous one-second needle biopsy technic is proposed. A simple device, consisting of a three-way deviator, allows the utilization of the standard needles for percutaneous biopsy. The entire procedure requires from 10 to 30 seonds. Large caliber needles from 1.6 to 2.0 mm are recommended. Complications are practically nonexistent.

Abdomen↗

Cyclic nucleotides and prostaglandins (PGs) produced by the rabbit oviduct: effects of estrogen treatment.

Levels of cyclic AMP and cyclic GMP have been measured in oviducts of rabbits killed 68 hr after injection of human chorionic gonadotrophin (HCG) to induce ovulation. cAMP and cGMP levels were higher in the isthmus than in the ampulla. Estrogen treatment given at the same time as HCG increased cGMP levels. Levels of PGE and PGF in blood draining the oviduct were low and showed no effect of estrogen treatment at 68 hr after HCG.

Animals↗

Fertility following microsurgical removal of the ampullary-isthmic junction in rabbits.

The role of the ampullary-isthmic junction (AIJ) in fertility was investigated in the rabbit by using microsurgical tuboplastic techniques. Microsurgical transection or resection of the AIJ failed to alter fertility significantly. Nine of ten rabbits which underwent unilateral transection of the AIJ became pregnant on the operated side and eight of the ten became pregnant on the unoperated control side. Of the ten rabbits which underwent unilateral AIJ resection, all became pregnant bilaterally. The results of this study indicate that the AIJ is not necessary for normal fertility in the rabbit.

Animals↗

The hormonal control of the guinea pig corpus luteum during early pregnancy.

Forty guinea pigs were divided into two groups, pregnant and nonpregnant, and were operated upon on days 10, 12, 14, and 16 of the ovarian cycle or of pregnancy. Blood was obtained from the utero-ovarian vein, and prostaglandin F2alpha (PGF2alpha), prostaglandin E (PGE), progesterone, and estrogen content was assayed by radioimmunoassay. Increased levels of PGF2alpha preceded a drop in progesterone levels in nonpregnant animals, reflecting luteolysis. In pregnant animals, the level of PGF2alpha remained low, and progesterone levels increased. PGE levels were similar in the two groups. These results suggest that the low PGF2alpha levels seen during early pregnancy are related to corpus luteum rescue.

Animals↗

[Ureterocele].

Explore the source record for details and available documents.

Adult↗

Effects of hypobaric hypoxia on the middle-latency and steady-state auditory evoked potentials.

The aim of the present paper was the investigation of middle-latency responses (MLRs) and steady-state responses (SSRs) during and after a 30-min exposure to hypobaric hypoxia (5182 m above sea level). The test was performed in a hypobaric chamber on 8 male audiologically normal volunteers. The auditory stimulus (500-Hz tone burst), delivered at rates of 10 and 40/s for MLRs and SSRs, respectively, was recalibrated in the hypobaric condition because of the reduced air density. Absolute latencies of waves Na and Pa and their interpeak amplitude were the MLR parameters investigated; for the SSRs, the first positive wave (P1) absolute latency and the interpeak amplitude between P1 and the first negative wave (N1) were considered. The results showed an absence of statistically significant modification of the MLRs. On the contrary, the SSRs showed a significant (p < 0.025) latency increase during hypoxia, with an immediate recovery upon return to ground level. No significant changes of SSR amplitudes were observed. One possible data interpretation is related to the higher stimulation rate adopted for the SSRs; a second possibility could be a different electrogenesis between MLRs and SSRs.

Acoustic Stimulation↗

Abdominal colpopexy for complete prolapse of the vagina.

A comparative study of abdominal colpopexy using rectus fascia and sacral fixation for the treatment of prolapsed vagina following hysterectomy was performed. The abdominal approach yields better results than the vaginal route. Fixation of the vaginal vault using a Dacron prosthesis is more rational and was the method of choice, resulting in a complete cure in 10 of 11 patients. The Brady technique failed in 25% of cases.

Abdominal Muscles↗