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R Asper

Publications and source records attributed to R Asper.

14 recordsLinked to original sources
PubMed1992

[Respective role of the size, location and composition of the calculus as determinants of therapeutic success after extracorporeal shock wave lithotripsy in renal lithiasis].

We evaluated the respective role of size, location and composition of renal stones as determinants of the outcome of extracorporeal shock wave lithotripsy (ESWL). The analysis of the chemical composition and of the morphology of the fragments eliminated by hundred patients who underwent ESWL has been made by X-rays diffraction. Results showed that the larger the stone, the higher the risk of having to perform an extra intervention (additional sessions of ESWL, percutaneous nephrostolithotomy, nephrolitholapaxy) or of finding residual fragments at the three month check-point. In addition, the location of the stone in a calice, especially a lower calice, strongly predisposes to incomplete elimination of the fragments. Finally, two types of stones appear to lessen the probability of success of ESWL: those of struvite and those of cystine. Indeed, out of eleven ESWL performed on struvite stones (pure or mixed), two had to be completed by percutaneous nephrolitholapaxy and even one by a nephrectomy because of superinfection. Out of the four patients with cystine stones, two had to be treated by additional percutaneous nephrolitholapaxy because of inadequate fragmentation after ESWL. However, for the remaining types of stones (pure or mixed) chemical composition seems to be less important than size or location.

Cystine↗
PubMed1990

Stone analysis.

Explore the source record for details and available documents.

Bilirubin↗
PubMed1987

Systemic treatment of cutaneous infections. A comparative study of ciprofloxacin and cefotaxime.

A prospective, double-blind, randomized study of hospitalized patients with skin and skin structure infections was conducted to compare orally administered ciprofloxacin and conventional intravenous cefotaxime therapy. Fifty-six patients, predominantly elderly women, were randomly assigned to receive either ciprofloxacin (24 patients, 25 infected sites) or cefotaxime (32 patients, 36 sites). Patients in the ciprofloxacin group received 750 mg of orally administered ciprofloxacin every 12 hours plus a placebo infusion while the other group received 2.0 g of cefotaxime intravenously every eight hours plus a placebo tablet every 12 hours. The average duration of treatment was seven to 10 days, with a maximum of 21 days. Clinical response per infected site in the ciprofloxacin group was as follows: resolution in 88 percent, improvement in 8 percent, and failure in 4 percent. In the cefotaxime group, there was resolution in 69 percent, improvement in 25 percent and failure in 6 percent. Bacteriologic response per site in the ciprofloxacin group was eradication in 88 percent and persistence in 12 percent. With cefotaxime there was 69 percent eradication, 3 percent marked reduction, 6 percent recurrence, and 22 percent persistence. Clinical and bacteriologic responses were combined using an algorithm to derive a cure rate, which was 91 percent for ciprofloxacin and 61 percent for cefotaxime (p = 0.0214).

Administration, Oral↗
PubMed1987

[Long-term problems of levodopa therapy in Parkinson disease].

The dependence of motor side effects of L-DOPA therapy on clinical and pharmacodynamic parameters was investigated in 28 patients with Parkinson's disease. Duration of disease and degree of motor impairment were significantly less in a first group of 12 patients without motor side effects than in a second group of 16 patients with fluctuations of antiparkinsonian effects and dyskinesias. The two groups showed different pharmacodynamic patterns: the antiparkinsonian effect in the first group remained unchanged, with decreasing DOPA plasma concentrations (Type I), whereas in the second group a direct correlation between DOPA plasma levels and antiparkinsonian effect was observed (Type II). A possible mechanism for the different pharmacodynamic patterns and its relevance for therapy are discussed.

Adult↗
PubMed1986

[Esophageal obstruction in tube feeding: a result of protein precipitation caused by antacids?].

A complication of tube feeding, i.e. thickening of nutrient solution in the presence of an antacid leading to obstruction of the esophagus, is reported. Three patients on artificial breathing where fed by tube with Fresubin liquid. At intervals, Alucol liquid was given for stress ulcer prevention through the tube. After 2, 4, and 50 days respectively, reflux of nutrient solution into the mouth occurred. On removal of the tube a compact, yellowish-white substance was extracted. Endoscopically, residual particles were found in the upper part of the esophagus and in the hypopharynx which obstructed the esophagus completely and in one case could only be extracted through a rigid esophagoscope. In vitro studies showed that thickening of the nutrient solution was due to interaction with antacids administered simultaneously with the nutrient.

Adult↗
PubMed1986

Critical aspects of urine and stone analysis. Appearance of iatrogenic urinary calculi.

In 25% of the samples the often applied qualitative chemical analysis of urinary stones leads to entirely wrong results with severe therapeutic consequences. The appropriate techniques for stone analysis are infrared spectroscopy and X-ray powder diffraction. These techniques make also possible the identification of iatrogenic urinary calculi. Four types of such stones were detected here, caused by modern medication. N4-acetylsulfamethoxazole, N4-acetylsulfadiazine, mefenamic acid and silicon dioxide. It is only the correct preanalytical treatment of urine samples that prevents considerable impairment of analytical results. Without precautions especially, the oxalate concentration in urine may be doubled or tripled during one day of storage.

False Positive Reactions↗
PubMed1986

Clinical significance of stone analysis.

The bases of a real metaphylaxis in the renal stone diseases are the analysis of stones and the research of metabolism in blood plasma and urine. The greatest part of the stones analyzed may be classified in four groups: oxalate, phosphate, uric acid and cystine. The metaphylaxis by whewellite and weddellite is the same for both species but there is a distinction in growth and recurrence. In the phosphate stones, the section with the most different composition, a postoperative therapy is only possible with the distinction of 'acid' and 'alkaline' stones. The uric acid and cystine stones need a tight supervision and metaphylaxis for the whole life. On the basis of 15,000 analyses with X-ray diffraction the difference of the renal stones is discussed and the deducation for a genuine metaphylaxis is shown.

Adult↗
PubMed1979

[Experiences with instrumental methods for urinary calculi analysis].

To reduce the urinary calculi incidence by calculi formers, it is important to know the composition of these stones. Unfortunately the chemical analysis does not give very reliable results. Looking for a better method to analyse urinary calculi, three instrumental methods were tested: infared spectroscopy, thermal analysis and X-ray diffraction. The experimental results and economical considerations show that the X-ray diffraction analysis of urinary calculi would meet the goal of improved care of patients with stones.

Humans↗
PubMed1979

On-line continuous potentiometric measurement of potassium concentration in whole blood during open-heart surgery.

We describe a flow-through system with an ion-selective electrode for measurement of blood potassium ion concentration, continuously and on-line off the extracorporeal blood circulation in an operating theater during human open-heart surgery. Comparison measurements were made with the SMA flame photometer (blood plasma) and an Orion SS 30 sodium/potassium analyzer (whole blood). The potassium concentration values obtained with the flow-through system agree well with the ones determined with the flame photometer. The time delay of the measurement with the flow-through system was relatively long (2 min) but delays of only 10--20 s seem feasible. Short time delays can deepen insight and simplify rational treatment under surgery conditions.

Autoanalysis↗