Biomedical subjects

R Aufrichtig

Publications and source records attributed to R Aufrichtig.

7 recordsLinked to original sources

PubMed2000

Dose efficiency and low-contrast detectability of an amorphous silicon x-ray detector for digital radiography.

The effect of dose reduction on low-contrast detectability is investigated theoretically and experimentally for a production grade amorphous silicon (a-Si) x-ray detector and compared with a standard thoracic screen-film combination. A non-prewhitening matched filter observer model modified to include a spatial response function and internal noise for the human visual system (HVS) is used to calculate a signal-to-noise ratio (SNR) related to object detectability. Other inputs to the SNR calculation are the detective quantum efficiency (DQE) and the modulation transfer function (MTF) of the imaging system. Besides threshold detectability, the model predicts the equivalent perception dose ratio (EPDR), which is the fraction of the screen film exposure for which the digital detector provides equal detectability. Images of a contrast-detail phantom are obtained with the digital detector at dose levels corresponding to 27%, 41%, 63% and 100% of the dose used for screen-film. The images are used in a four-alternative forced choice (4-AFC) observer perception study in order to measure threshold detectability. A statistically significant improvement in contrast detectability is measured with the digital detector at 100% and 63% of the screen-film dose. There is no statistical difference between screen-film and digital at 41% of the dose. On average, the experimental EPDR is 44%, which agrees well with the model prediction of 40%.

Equipment Design↗

PubMed2000

Performance of a 41X41-cm2 amorphous silicon flat panel x-ray detector for radiographic imaging applications.

We report the performance of a 41 X 41-cm2 amorphous silicon-based flat panel detector designed for radiographic imaging applications. The detector consists of an array of photodiodes and thin film transistor switches on a 0.2-mm pitch with an overlying thallium-doped cesium iodide scintillator. The performance of the detector was evaluated through measurement of the frequency-dependent detective quantum efficiency [DQE(f)]. Measurements of the characteristic curve and modulation transfer function (MTF) are also reported. All measurements were made in a radiographic imaging mode with a readout time of 125 ms. We evaluated a total of 15 detectors. One detector was characterized at a range of exposures and at three different electronic gain settings. Measurements of DQE(f) and MTF were also performed as a function of position on one detector. The measured DQE at an exposure of about 1 mR was 0.66 at zero spatial frequency and fell smoothly with frequency to a value of 0.24 at the Nyquist frequency, 2.5 cycles/mm. The DQE is independent of exposure for exposures in the upper 80% of each gain range, but is reduced somewhat at lower exposures because of the influence of additive system noise. The reduction can be controlled by adjusting the electronic gain. For a gain that allows a maximum exposure of 5 mR, the DQE at 0.056 mR was 0.64 at zero frequency and 0.19 at 2.5 cycles/mm. The standard deviation in DQE among measurements on different detectors was less than 0.02 at any frequency. The presampling MTF was 0.26 at 2.5 cycles/mm. The standard deviation in MTF among measurements on different detectors was less than 0.01 at any frequency. Both MTF and DQE were substantially independent of position on the detector.

Biophysical Phenomena↗

PubMed1999

Perception of temporally filtered X-ray fluoroscopy images.

For noisy X-ray fluoroscopy image sequences we quantitatively evaluated image quality after digital temporal filtering to reduce noise. Using an experimental paradigm called a reference/test adaptive forced-choice method we compared detectability of stationary low-contrast disks in filtered and unfiltered, computer-generated image sequences. In the first experiment, a low-pass first-order recursive filter used in X-ray fluoroscopy was found to be much less effective at enhancing detectability than predicted from the reduction of display noise variance, a common measurement of filter effectiveness. Detectability was reasonably predicted by a nonprewhitening human-observer model (NPW-HVS) that included an independently determined human temporal-contrast-sensitivity function. In another experiment, designed to test models over a range of temporal frequencies, we used paired high-pass and low-pass temporal filters that both reduced noise variance by 25%. The high-pass filter was artificially applied to the noise only and greatly improved detectability, while the low-pass filter had little effect. The human-observer model quantitatively described the measurements, but classical prewhitening and nonprewhitening signal detectors did not. As compared to the nonprewhitening, spatio-temporal matched filter, human-observer efficiency was low and variable at 2.1%, 2.9%, and 0.06% for 60 frames of unfiltered low-pass and high-pass noise, respectively. As compared to this detector, humans were not very effective at combining information across frames. On the other hand, signal to noise ratios (SNR's) from the human-observer model were comparable to human performance, and efficiencies were reasonably constant at 40%, 52%, and 32%, respectively. We conclude that it is imperative to include human-observer models and experiments in the analysis of noise-reduction filtering of noisy image sequences, such as X-ray fluoroscopy.

Adult↗

PubMed1999

Comparison of low contrast detectability between a digital amorphous silicon and a screen-film based imaging system for thoracic radiography.

Low contrast threshold detectability is investigated theoretically and experimentally for an amorphous silicon (a-Si) x-ray detector designed for digital radiography and for a standard thoracic screen-film combination. A theoretical signal-to-noise ratio is described with a human observer signal detection model. It is calculated using the detective quantum efficiency (DQE) and the modulation transfer function of the imaging system, as well as a spatial response function for the human visual system. Using a four-alternative forced choice observer perception study, the threshold contrasts of disk shaped objects ranging in size from 0.3 to 4.0 mm are determined. Significantly better contrast detectability is obtained from the digital detector, which is attributed to its higher DQE. On average, the disk shaped objects can be detected at 45% less contrast than required for screen-film. With no free parameters the experimental data agree well with those predicted by the observer model. Based upon the data, the model predicts that x-ray exposure for the a-Si detector only needs to be 30% of the exposure required to perform equally well on the contrast-detail detectability task using screen-film.

Equipment Design↗

PubMed1994

Perception of fluoroscopy last-image hold.

Last-image hold (LIH) is used in x-ray fluoroscopy systems as a convenience and dose savings feature. In the case of an image sequence, temporal filtering in the human visual system (HVS) reduces perceived noise. In the case of a constant, single image frame, this phenomenon is not present: the image looks noisier, and low-contrast objects disappear. Using low-contrast, stationary cylinder and disk phantoms in noise, perception of single frames are compared with that of conventional 30 acq/s continuous fluoroscopy (continuous). The dose of continuous is fixed at Q/acq, and the dose of single-frame presentations is varied in order to determine an "equivalent-perception dose" for a paired-comparison task. The equivalent-perception dose depends upon the shape and size of an object. As cylinder diameter increases from 1 to 21 pixels, the equivalent-perception dose decreases from 4.6 to 2.8 Q/acq. At equal equivalent-perception dose values, the relationship between cylinder and disk diameters are determined; a cylinder diameter of 10 pixels is roughly equivalent to a disk diameter of 20 pixels. For interventional angiography, an average equivalent-perception dose of approximately 3.5 Q/acq for a single-frame presentation is predicted. Thus processing by the HVS effectively reduces noise variance by a factor of 3.5, corresponding to an effective averaging time of 3.5 frames or 120 ms. Several variance reduction techniques are suggested to create an LIH frame having perception equal to the fluoroscopy sequence.

Biophysical Phenomena↗

PubMed1994

Perceptual comparison of pulsed and continuous fluoroscopy.

Pulsed fluoroscopy (hereafter called pulsed) at reduced acquisition rates, typically 15 acq/s (pulsed-15), is proposed to reduce x-ray dose in interventional procedures. However, since the human visual system (HVS) acts as a temporal low-pass filter that interacts with such acquisitions, the proper dose for pulsed must be obtained in perception experiments. We determine the dose for low-frame-rate pulsed that gives visualization equivalent to that of conventional 30 acq/s fluoroscopy, hereafter called continuous. Computer-generated phantoms are used. They consist of stationary, low-contrast disks on a flat background containing Poisson noise that mimics quantum noise in fluoroscopy. Image sequences are displayed on the video tachistoscope, a device with considerable display flexibility. Three experimental paradigms are used. (1) In a paired-comparison study, pulsed and continuous are displayed side-by-side on the same monitor, and the visibility of a contrast detail phantom is compared. (2) Using this same display, subjects record the minimally detectable disk contrast (the min-contrast measurement). (3) In a four-alternative forced-choice experiment, a disk is placed in one of four positions, and the subject determines the position of the disk. The methods are complementary--the forced-choice experiment properly eliminates the subjectivity of the observer threshold while the paired-comparison study is much more time efficient. With regard to pulsed and continuous comparisons, remarkable similarity is found between the supra-threshold experiments (1 and 2) and the detectability experiment (3); i.e., the average absolute differences in the equivalent-perception dose as determined by the three measures is approximately 3%. No difference is found between interlaced and noninterlaced display. A relatively small dependence of dose savings on disk size is found with larger disks giving increased dose savings. Average dose savings of 22%, 38%, and 49% are found for pulsed-15, pulsed-10, and pulsed-7.5, respectively.

Fluoroscopy↗

PubMed1994

Model for perception of pulsed fluoroscopy image sequences.

Pulsed fluoroscopy at reduced frame rates can be used to lower x-ray dose with equivalent detection (hereafter called equivalent perception) of low-contrast, stationary objects. Experimentally average dose savings of 22%, 38%, and 49%, for pulsed fluoroscopy at 15, 10, and 7.5 acquisitions per second, respectively, are documented. Dose savings depend on object size, with fewer savings for smaller objects. To explain these data, we extend the framework of an ideal observer with three models for the spatiotemporal response of the human visual system (HVS). They are model 1, separable; model 2, nonseparable; and model 3, nonseparable with internal observer noise. With no free parameters, model 1 predicts the average dose savings within a 3% difference but does not describe the effect of object size. Models 2 and 3 explain the influence of size, and model 3, with a single free parameter, fits the measurements best. Perception of pulsed fluoroscopy is thus well described in terms of spatiotemporal processing by the HVS.

Fluoroscopy↗