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Biomedical subjects

R Awasthi

Publications and source records attributed to R Awasthi.

10 recordsLinked to original sources
PubMed2005

Biphasic solitary fibrous tumour: a report of two cases with epithelioid features.

We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components. Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry. Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma. Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance. In one of the cases, the epithelioid area, which was well circumscribed and showed packeting of cell groups, demonstrated expression of cytokeratin and epithelial cadherin but not of CD34. In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component. These findings suggest that epithelioid change in SFT shows a range of differentiation at one end, similar to that of a standard SFT, and at the other end, possibly acquiring epithelial characteristics.

Biomarkers, Tumor↗
PubMed2005

Evaluation of perineurial differentiation in epithelioid sarcoma.

AIMS: To investigate the differentiation pattern of epithelioid sarcoma in terms of perineurial and endothelial differentiation, and its relationship to that of meningioma. METHODS AND RESULTS: Nine cases of epithelioid sarcoma and five cases of meningioma were studied in an immunohistochemical analysis of 'perineurial' antigens [GLUT-1, claudin-1, epithelial membrane antigen (EMA) and VE-cadherin] and of 'endothelial' antigens not present on normal perineurium (CD34, CD31, Fli-1). Both epithelioid sarcoma and meningioma showed frequent expression of the perineurial markers GLUT-1, claudin-1 and EMA. VE-cadherin was identified in one of five meningiomas, and in the only case of epithelioid sarcoma in which suitably fixed material was available. CD34 was expressed by all epithelioid sarcomas studied but by none of the meningiomas. Fli-1 was present in a substantial majority of epithelioid sarcomas and by all the meningiomas. CD31 was not detected in any epithelioid sarcoma or meningioma. CONCLUSIONS: The results were evaluated in the context of previous immunohistochemical, ultrastructural and genetic studies and suggest that epithelioid sarcoma may be a form of malignant perineurioma with a range of differentiation (epithelial features) akin to that seen in meningioma, reflecting the close relationship between perineurium and meningothelium.

Antigens, CD↗
PubMed2004

Benign mixed tumour of the skin with extensive ossification and marrow formation: a case report.

Benign mixed tumour of the skin (chondroid syringoma) is an uncommon skin adnexal tumour, usually presenting as a slow growing solitary painless nodule. The morphological appearances are similar to those of a pleomorphic adenoma of the salivary gland. Hair matrix and sebaceous differentiation can be seen in some lesions. Focal ossification is a rare finding. This report presents a case of a similar tumour arising in the cheek of a 43 year old white man, showing extensive ossification. Clinical, radiological, and pathological correlation and diagnosis proved to be difficult preoperatively. Only two cases of a benign mixed tumour with pronounced ossification have been reported so far, both in Japanese patients. This is the first reported case seen in a white man. Awareness of these lesions will avoid potential diagnostic pitfalls.

Adenoma, Pleomorphic↗
PubMed1996

Blood lead in pregnant women in the urban slums of Lucknow, India.

OBJECTIVES: To determine the concentrations of blood lead (PbB) in pregnant women in the slums of Lucknow, north India. METHODS: Of the 203 designated municipal slums in Lucknow, 70 were randomly selected for study and a cohort of 500 pregnant women was enrolled. Each participant was interviewed with questions on possible sources of exposure to lead, surrogates of nutritional status were measured, and PbB was measured. RESULTS: The mean PbB was 14.3 micrograms/dl and 19.2% of women had PbB > or = 20 micrograms/dl. PbB was not associated with age, height, weight, gestation, or history of abortions, although higher PbB was associated with higher parity. Women living inner city neighbourhoods near heavy vehicular traffic had PbB 2.2 micrograms/dl higher (95% confidence interval (95% CI) 0.8 to 3.6) than those living in other neighbourhoods. The PbB was not associated with reported use of piped water or the presence of paint in homes, and increasing PbB was unexpectedly associated with decreasing use of eye cosmetic "surma" and the duration of gestation. CONCLUSIONS: The high PbB found in this population raises concern about fetal development and points to the urgent need to reduce exposure to lead.

Adult↗
PubMed1996

Brainstem auditory evoked responses in primary hypertension.

Brainstem auditory evoked potential responses (BAEPs) were recorded from CZ-A1 and CZ-A2 scalp regions in 23 hypertensive and 14 normotensive subjects. Hypertension was graded depending upon the extent of raised blood pressure. BAEPs in patients of grade I and II hypertension did not show any change when compared to normotensive subjects. However, grade III hypertensive case showed significant prolongation of absolute peak latencies of wave I, II, V and interpeak latency of wave III-V indicating involvement of brainstem auditory pathways. Multiple regression analysis revealed significant correlation of rise in systolic and diastolic blood pressure with absolute peak latencies of BAEPs in hypertensive patients.

Auditory Pathways↗
PubMed1989

Spontaneous and quinine induced hypoglycaemia in severe falciparum malaria.

Four of 21 patients with cerebral malaria developed hypoglycaemia, defined as plasma glucose concentration below 40 mg/dl (2.2 mmol/l). Two patients had spontaneous hypoglycaemia at admission and the other two developed it subsequent to quinine therapy. All recovered with continuous intravenous glucose infusion. Spontaneous hypoglycaemia in malaria has not earlier been reported from India.

Adolescent↗
PubMed1989

Extrapyramidal syndrome in falciparum malaria.

Three unusual cases of falciparum malaria with extrapyramidal syndrome are reported. Two of these cases had extrapyramidal features at admission and the other one developed them after quinine therapy.

Adolescent↗