Effect of pentamethylenetetrazol on structure and enzyme activity of yeast. I. Changes in mitochondria and in sterol levels.
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Chromatography, Paper↗
Biomedical subjects
R B Alexander
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Mexiletine: biphasic action on convulsive seizures in rodents.
Mexiletine, an antiarrhythmic drug, exerted a protective effect in mice against convulsive seizures induced by electroshock or the chemical convulsant, pentylenetetrazol, and against seizures induced in inbred audiosusceptible mice by a sound signal. Administered in large doses, mexiletine produced a hyperkinetic myoclonic syndrome of 30-60 min duration. The hyperkinesia could be controlled by dimethylaminoethanol, phenobarbital and by an experimental anticonvulsive agent, eboracin.
Acoustic Stimulation↗