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Biomedical subjects

R B Ashorobi

Publications and source records attributed to R B Ashorobi.

5 recordsLinked to original sources
PubMed1995

Indomethacin and alpha-tocopheral enhanced survival in endotoxic rats.

Induced endotoxaemia was studied in healthy male albino rats injected intravenously with lipopolysaccharide from Escherichia coli at 10, 20 and 30 mg/kg dose levels. The endotoxic rats were closely observed for mortality within 48 hours and subsequently for seven days. Within five hours post administration over 50 pc mortality was observed at dose levels of 20 to 30 mg/kg. Pre-treatment of rats with Indomethacin (250 mg/kg) alone and alpha-tocopheral (100 mg/kg) produced significant protective effects with the mortality rate reduced to 50 pc at the highest endotoxin dose level. Interestingly a combination of both drugs significantly improved survival with an observed mortality of 20 pc. Prednisolone (500 mg/kg) either alone or in combination with indomethacin or alpha-tocopherol did not offer any advantage. Instead the mortality rate was significantly high. A combination of Indomethacin and alpha-tocopheral significantly improved survival in endotoxic rats.

Animals↗
PubMed1995

Effects of calcium ions and atropine on endotoxin-induced contractility deficit in rat atrial muscle.

Isolated atrial muscle preparations obtained from rats injected (ip) with 3.7 x 10(9) per kg/body weight heat killed pure E. coli (endotoxin) were used to investigate the severity of induced mycocardial inotropic dysfunction and the effects of some autonotic agents and calcium. Both atrial strips were removed from endotoxin-shock rats at 48 and 72 hours post treatment. The control groups were given (ip) 0.2ml of isotonic saline and sacrificed at the same period as the treated groups. Maximum developed contractile force (amplitude) were significantly depressed in atrial strips of shock rats (p < 0.05). Maximum deficit in atrial contractility was characterised by altered responsiveness to low extra cellular Ca2+ (0.12mM) concentration. Increasing Ca2+ concentration by 1-3 mM in a normal Ca2+ medium significantly enhanced the contractile force by an increase of 88 +/- 5.9% (p < 0.005). Atropine (5 x 10(-7) - 1.5 x 10(-6)M) produced positive intropic effect with a maximum increase of 80 +/- 7.1% (p < 0.05) in the shock atrial strips. Noradrenaline (1 x 10(-7)-10(-6)) on the other hand, did not produce any significant inotropic effect. Concomitant administration of noradrenaline (1 x 10(-6)M) and atropine (1.5 x 10(-5)M) produced positive inotropic effect which is not greater in magnitude compared with atropine (5 x 10(-7)M). This study suggests that Ca2+ and atropine may provide beneficial effects in endotoxin-induced shock state. It also confirms the involvement of myocardium in the pathogenesis of this condition.

Animals↗
PubMed1984

Interaction between frusemide and aspirin.

The effects of the combination of aspirin and frusemide were studied on salicylate excretion by aspirin and on the diuresis and excretion of K+ and Na+ by frusemide in normal human subjects. There was a paradoxical net reduction in the natriuresis induced by aspirin, from 29.4 +/- 3.57 m-equiv and frusemide from 31.9 +/- 1.27 to 23.7 +/- 1.56 m-equiv on combined administration. Frusemide caused a reduction of the kalliuretic effect induced by aspirin from 48.86 +/- 8.36 to 18.3 +/- 3.76 m-equiv. The amount of salicylate excreted over a 3-hr period gave increases of 9.6 and 12.0% when aspirin was administered before frusemide and vice versa, respectively, while there was a 30.4% reduction when administered concomitantly.

Adult↗
PubMed1979

Electrophysiological correlates of the behavioral effects of tubocurarine in conscious cats.

The effects of tubocurarine on behavior, electrical activity, and auditory evoked potentials were studied in restrained conscious cats. Tubocurarine hydrochloride (doses of 0.05--1 micrograms intraventricularly) produced various central stimulatory effects characterized by EEG desynchronization, decrease in both low (7--9 Hz) and high (10--14 Hz) alpha waves, and decrease in the amplitude and area of the surface positive (P1) wave of auditory evoked potentials. Concomitant with the alterations in brain electrical activity tubocurarine hydrochloride produced generalized behavioral arousal phenomena and the cats became restless and exhibited miaowing and increased movement of the head and ears. Almost all parameters except behavior showed a distinct dose-response relationship. A correlation between the behavioral effects and the EEG analog was thus demonstrated.

Alpha Rhythm↗