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Biomedical subjects

R B Atwell

Publications and source records attributed to R B Atwell.

At least 73 records · Page 4Linked to original sources

Angles of branching and the diameters of pulmonary arteries in relation to the distribution of pulmonary lesions in canine dirofilariasis.

Latex casts were made of the pulmonary arteries in 10 normal dogs. These casts were used to measure the angles of deviation of the right and left pulmonary arteries from the pulmonary trunk. The measurements were made in three projections. In both craniocaudal and dorsoventral projections the right pulmonary artery deviated more from the axis of the pulmonary trunk than did the left pulmonary artery. In the lateral projection, the right artery deviated ventrally and the left deviated dorsally, but the angles of deviation were similar. The diameter of the right pulmonary artery was significantly larger than that of the left. This difference in size of the major arteries could be a major determinant in the distribution of lesions in dirofilariasis. However the curved pathway taken by the blood as it is ejected from the right ventricle and the angles of deviation of the arteries as they branch from the pulmonary trunk could also play a part in the distribution of the lesions.

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Early stages of disease of the peripheral pulmonary arteries in canine dirofilariasis.

Peripheral pulmonary arterial disease sometimes associated with immature filariae (larvae) was found in 5 dogs in which infestations of D. immitis were considered to be relatively recent. Gross and histological arterial lesions were similar to the endarteritis described in association with adult filariae. No adult filariae were associated with these peripheral lesions.

Animals↗

The use of alpha blockade in the treatment of congestive heart failure associated with dirofilariasis and mitral valvular incompetence.

Four dogs with congestive heart failure associated with dirofilariasis and mitral valvular incompetence initially responded to treatment with digoxin or etamiphylline camsylate, and frusemide but became refractory to this therapy and were in cardiac decompensation. Frusemide dosage was increased and the alpha adrenoreceptor blocking drug prazosin hydrochloride was added to the therapeutic regime. Six weeks later all dogs were stabilized and their clinical condition was markedly improved.

Animals↗

The effectiveness of levamisole hydrochloride in the treatment of adult Dirofilaria immitis.

Dogs infected with D. immitis were treated with oral levamisole hydrochloride at various dose rates over different durations. Clinical toxicity, haematological and biochemical parameters, body weight and food intake were recorded and filarial mortality estimated at autopsy. All filariae were dead in dogs treated at 10 mg/kg body weight twice daily (12 hourly) for 14 days, with minimal clinical toxicity being seen during the treatment period.

Animals↗